Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease

The relationship between amyloid-β species and tau pathology in Alzheimer’s disease is not fully understood. Here, the authors show that it is the increased ratio of amyloid-β42 and 40 isoforms drives tau pathology in 3D human neural cell culture models of the disease.

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Autores principales:	Sang Su Kwak, Kevin J. Washicosky, Emma Brand, Djuna von Maydell, Jenna Aronson, Susan Kim, Diane E. Capen, Murat Cetinbas, Ruslan Sadreyev, Shen Ning, Enjana Bylykbashi, Weiming Xia, Steven L. Wagner, Se Hoon Choi, Rudolph E. Tanzi, Doo Yeon Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c1c3533dcca447694dd527474cb0871
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spelling	oai:doaj.org-article:0c1c3533dcca447694dd527474cb08712021-12-02T17:31:08ZAmyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease10.1038/s41467-020-15120-32041-1723https://doaj.org/article/0c1c3533dcca447694dd527474cb08712020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15120-3https://doaj.org/toc/2041-1723The relationship between amyloid-β species and tau pathology in Alzheimer’s disease is not fully understood. Here, the authors show that it is the increased ratio of amyloid-β42 and 40 isoforms drives tau pathology in 3D human neural cell culture models of the disease.Sang Su KwakKevin J. WashicoskyEmma BrandDjuna von MaydellJenna AronsonSusan KimDiane E. CapenMurat CetinbasRuslan SadreyevShen NingEnjana BylykbashiWeiming XiaSteven L. WagnerSe Hoon ChoiRudolph E. TanziDoo Yeon KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sang Su Kwak Kevin J. Washicosky Emma Brand Djuna von Maydell Jenna Aronson Susan Kim Diane E. Capen Murat Cetinbas Ruslan Sadreyev Shen Ning Enjana Bylykbashi Weiming Xia Steven L. Wagner Se Hoon Choi Rudolph E. Tanzi Doo Yeon Kim Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease
description	The relationship between amyloid-β species and tau pathology in Alzheimer’s disease is not fully understood. Here, the authors show that it is the increased ratio of amyloid-β42 and 40 isoforms drives tau pathology in 3D human neural cell culture models of the disease.
format	article
author	Sang Su Kwak Kevin J. Washicosky Emma Brand Djuna von Maydell Jenna Aronson Susan Kim Diane E. Capen Murat Cetinbas Ruslan Sadreyev Shen Ning Enjana Bylykbashi Weiming Xia Steven L. Wagner Se Hoon Choi Rudolph E. Tanzi Doo Yeon Kim
author_facet	Sang Su Kwak Kevin J. Washicosky Emma Brand Djuna von Maydell Jenna Aronson Susan Kim Diane E. Capen Murat Cetinbas Ruslan Sadreyev Shen Ning Enjana Bylykbashi Weiming Xia Steven L. Wagner Se Hoon Choi Rudolph E. Tanzi Doo Yeon Kim
author_sort	Sang Su Kwak
title	Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease
title_short	Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease
title_full	Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease
title_fullStr	Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease
title_full_unstemmed	Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease
title_sort	amyloid-β42/40 ratio drives tau pathology in 3d human neural cell culture models of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0c1c3533dcca447694dd527474cb0871
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Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer’s disease

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