Scalable recombinase-based gene expression cascades

There are few robust circuit architectures for sequential gene perturbations. Here, the authors use a modular recombinase-based design that sequentially edits loci, synchronizes cells, and deletes itself.

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Detalles Bibliográficos
Autores principales:	Tackhoon Kim, Benjamin Weinberg, Wilson Wong, Timothy K. Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c21854435d549eeaf4ce8f46f2e69c0
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spelling	oai:doaj.org-article:0c21854435d549eeaf4ce8f46f2e69c02021-12-02T14:35:39ZScalable recombinase-based gene expression cascades10.1038/s41467-021-22978-42041-1723https://doaj.org/article/0c21854435d549eeaf4ce8f46f2e69c02021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22978-4https://doaj.org/toc/2041-1723There are few robust circuit architectures for sequential gene perturbations. Here, the authors use a modular recombinase-based design that sequentially edits loci, synchronizes cells, and deletes itself.Tackhoon KimBenjamin WeinbergWilson WongTimothy K. LuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tackhoon Kim Benjamin Weinberg Wilson Wong Timothy K. Lu Scalable recombinase-based gene expression cascades
description	There are few robust circuit architectures for sequential gene perturbations. Here, the authors use a modular recombinase-based design that sequentially edits loci, synchronizes cells, and deletes itself.
format	article
author	Tackhoon Kim Benjamin Weinberg Wilson Wong Timothy K. Lu
author_facet	Tackhoon Kim Benjamin Weinberg Wilson Wong Timothy K. Lu
author_sort	Tackhoon Kim
title	Scalable recombinase-based gene expression cascades
title_short	Scalable recombinase-based gene expression cascades
title_full	Scalable recombinase-based gene expression cascades
title_fullStr	Scalable recombinase-based gene expression cascades
title_full_unstemmed	Scalable recombinase-based gene expression cascades
title_sort	scalable recombinase-based gene expression cascades
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0c21854435d549eeaf4ce8f46f2e69c0
work_keys_str_mv	AT tackhoonkim scalablerecombinasebasedgeneexpressioncascades AT benjaminweinberg scalablerecombinasebasedgeneexpressioncascades AT wilsonwong scalablerecombinasebasedgeneexpressioncascades AT timothyklu scalablerecombinasebasedgeneexpressioncascades
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Scalable recombinase-based gene expression cascades

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