Scalable recombinase-based gene expression cascades

There are few robust circuit architectures for sequential gene perturbations. Here, the authors use a modular recombinase-based design that sequentially edits loci, synchronizes cells, and deletes itself.

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Bibliographic Details
Main Authors: Tackhoon Kim, Benjamin Weinberg, Wilson Wong, Timothy K. Lu
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Q
Online Access:https://doaj.org/article/0c21854435d549eeaf4ce8f46f2e69c0
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