Modulation of Chronic Inflammation by Quercetin: The Beneficial Effects on Obesity

Shin Sato,1 Yuuka Mukai2 1Department of Nutrition, Aomori University of Health and Welfare, Aomori 030-8505, Japan; 2School of Nutrition and Dietetics, Faculty of Health and Social Work, Kanagawa University of Human Services, Kanagawa 238-8522, JapanCorrespondence: Shin SatoDepartment of Nutrition,...

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Autores principales:	Sato S, Mukai Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	quercetin inflammation obesity insulin resistance atherosclerosis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/0c26d62056fe421688266b8a2ae3e219
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spelling	oai:doaj.org-article:0c26d62056fe421688266b8a2ae3e2192021-12-02T12:52:41ZModulation of Chronic Inflammation by Quercetin: The Beneficial Effects on Obesity1178-7031https://doaj.org/article/0c26d62056fe421688266b8a2ae3e2192020-08-01T00:00:00Zhttps://www.dovepress.com/modulation-of-chronic-inflammation-by-quercetin-the-beneficial-effects-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Shin Sato,1 Yuuka Mukai2 1Department of Nutrition, Aomori University of Health and Welfare, Aomori 030-8505, Japan; 2School of Nutrition and Dietetics, Faculty of Health and Social Work, Kanagawa University of Human Services, Kanagawa 238-8522, JapanCorrespondence: Shin SatoDepartment of Nutrition, Aomori University of Health and Welfare, Mase 58-1, Hamadate, Aomori 030-8505, JapanTel/ Fax +81-17-765-4184Email s_sato3@auhw.ac.jpAbstract: Obesity has become a major risk factor for the development of chronic diseases such as insulin resistance, type 2 diabetes mellitus, and cardiovascular disease. Moreover, obesity induces chronic inflammation in adipose tissue, liver, skeletal muscle, and the vascular system. Quercetin is the major representative of the flavonoid subclass of flavonols, which is ubiquitously contained within natural plants such as green tea, and vegetables, including onions and apples. Researchers have focused greater attention to the beneficial physiological roles of quercetin, which has anti-oxidative, anti-inflammatory, and anti-fibrotic effects on insulin resistance and atherosclerosis in obesity-related diseases. Also, the anti-inflammatory effects of quercetin on intestinal microbiota have been demonstrated in obesity. In addition, there is increasing evidence that quercetin is associated with epigenetic activities in cancer, and in maternal undernutrition during gestation and lactation. In this review, we focus on the chemical properties of quercetin, its dietary sources in obesity, and its anti-inflammatory effects on insulin resistance, atherosclerosis, intestinal microbiota, and maternal under-nutrition with epigenetic activity.Keywords: quercetin, inflammation, obesity, insulin resistance, atherosclerosisSato SMukai YDove Medical Pressarticlequercetininflammationobesityinsulin resistanceatherosclerosisPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 421-431 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	quercetin inflammation obesity insulin resistance atherosclerosis Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	quercetin inflammation obesity insulin resistance atherosclerosis Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Sato S Mukai Y Modulation of Chronic Inflammation by Quercetin: The Beneficial Effects on Obesity
description	Shin Sato,1 Yuuka Mukai2 1Department of Nutrition, Aomori University of Health and Welfare, Aomori 030-8505, Japan; 2School of Nutrition and Dietetics, Faculty of Health and Social Work, Kanagawa University of Human Services, Kanagawa 238-8522, JapanCorrespondence: Shin SatoDepartment of Nutrition, Aomori University of Health and Welfare, Mase 58-1, Hamadate, Aomori 030-8505, JapanTel/ Fax +81-17-765-4184Email s_sato3@auhw.ac.jpAbstract: Obesity has become a major risk factor for the development of chronic diseases such as insulin resistance, type 2 diabetes mellitus, and cardiovascular disease. Moreover, obesity induces chronic inflammation in adipose tissue, liver, skeletal muscle, and the vascular system. Quercetin is the major representative of the flavonoid subclass of flavonols, which is ubiquitously contained within natural plants such as green tea, and vegetables, including onions and apples. Researchers have focused greater attention to the beneficial physiological roles of quercetin, which has anti-oxidative, anti-inflammatory, and anti-fibrotic effects on insulin resistance and atherosclerosis in obesity-related diseases. Also, the anti-inflammatory effects of quercetin on intestinal microbiota have been demonstrated in obesity. In addition, there is increasing evidence that quercetin is associated with epigenetic activities in cancer, and in maternal undernutrition during gestation and lactation. In this review, we focus on the chemical properties of quercetin, its dietary sources in obesity, and its anti-inflammatory effects on insulin resistance, atherosclerosis, intestinal microbiota, and maternal under-nutrition with epigenetic activity.Keywords: quercetin, inflammation, obesity, insulin resistance, atherosclerosis
format	article
author	Sato S Mukai Y
author_facet	Sato S Mukai Y
author_sort	Sato S
title	Modulation of Chronic Inflammation by Quercetin: The Beneficial Effects on Obesity
title_short	Modulation of Chronic Inflammation by Quercetin: The Beneficial Effects on Obesity
title_full	Modulation of Chronic Inflammation by Quercetin: The Beneficial Effects on Obesity
title_fullStr	Modulation of Chronic Inflammation by Quercetin: The Beneficial Effects on Obesity
title_full_unstemmed	Modulation of Chronic Inflammation by Quercetin: The Beneficial Effects on Obesity
title_sort	modulation of chronic inflammation by quercetin: the beneficial effects on obesity
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/0c26d62056fe421688266b8a2ae3e219
work_keys_str_mv	AT satos modulationofchronicinflammationbyquercetinthebeneficialeffectsonobesity AT mukaiy modulationofchronicinflammationbyquercetinthebeneficialeffectsonobesity
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Modulation of Chronic Inflammation by Quercetin: The Beneficial Effects on Obesity

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