Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression

Laura Gedge1, Lauren Lazowski1, David Murray2, Ruzica Jokic2,3, Roumen Milev2,31Centre for Neuroscience Studies, 2Department of Psychiatry, Queen&rsquo;s University, Kingston, 3Providence Care-Mental Health Services, Kingston, Ontario, CanadaObjective: To determine the effect of adjunctive q...

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Autores principales:	Laura Gedge, Lauren Lazowski, David Murray, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0c28695ab8464d30a0f9ddfe301a4da1
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spelling	oai:doaj.org-article:0c28695ab8464d30a0f9ddfe301a4da12021-12-02T00:59:15ZEffects of quetiapine on sleep architecture in patients with unipolar or bipolar depression1176-63281178-2021https://doaj.org/article/0c28695ab8464d30a0f9ddfe301a4da12010-08-01T00:00:00Zhttp://www.dovepress.com/effects-of-quetiapine-on-sleep-architecture-in-patients-with-unipolar--a4998https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Laura Gedge1, Lauren Lazowski1, David Murray2, Ruzica Jokic2,3, Roumen Milev2,31Centre for Neuroscience Studies, 2Department of Psychiatry, Queen&rsquo;s University, Kingston, 3Providence Care-Mental Health Services, Kingston, Ontario, CanadaObjective: To determine the effect of adjunctive quetiapine therapy on the sleep architecture of patients with bipolar or unipolar depression.Methods: This is a prospective, single-blind, repeated measures polysomnographic study. Sleep architecture was analyzed by overnight polysomnography, and subjective sleep quality was measured using the Pittsburgh Sleep Quality Index. The Hamilton Rating Scale for Depression, Montgomery Asberg Depression Rating Scale, Young Mania Rating Scale, and Clinical Global Impression-Severity Scale were employed to quantify changes in illness severity with adjunctive quetiapine treatment. Polysomnographs and clinical measures were administered at baseline, after 2&ndash;4 days of treatment, and after 21&ndash;28 days of quetiapine treatment. The average dose of quetiapine was 155 mg, ranging from 100&ndash;200 mg.Results: Adjunctive quetiapine therapy did not significantly alter sleep efficiency, sleep continuity, or Pittsburgh Sleep Quality Index scores. Respiratory Disturbance Index and percentage of total time in rapid eye movement (REM) sleep significantly decreased and the percentage of total time in non-REM sleep, and duration of Stage 2 and non-REM sleep significantly increased after 2&ndash;4 days of quetiapine treatment. Illness severity significantly decreased over time.Conclusions: Adjunctive quetiapine treatment alters sleep architecture in patients with major depressive disorder or bipolar disorder, which may partially explain its early antidepressant properties. Changes in sleep architecture are more robust and significant within two to four days of starting treatment.Keywords: quetiapine, sleep architecture, depression, bipolar disorder Laura GedgeLauren LazowskiDavid Murrayet alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 501-508 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Laura Gedge Lauren Lazowski David Murray et al Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression
description	Laura Gedge1, Lauren Lazowski1, David Murray2, Ruzica Jokic2,3, Roumen Milev2,31Centre for Neuroscience Studies, 2Department of Psychiatry, Queen&rsquo;s University, Kingston, 3Providence Care-Mental Health Services, Kingston, Ontario, CanadaObjective: To determine the effect of adjunctive quetiapine therapy on the sleep architecture of patients with bipolar or unipolar depression.Methods: This is a prospective, single-blind, repeated measures polysomnographic study. Sleep architecture was analyzed by overnight polysomnography, and subjective sleep quality was measured using the Pittsburgh Sleep Quality Index. The Hamilton Rating Scale for Depression, Montgomery Asberg Depression Rating Scale, Young Mania Rating Scale, and Clinical Global Impression-Severity Scale were employed to quantify changes in illness severity with adjunctive quetiapine treatment. Polysomnographs and clinical measures were administered at baseline, after 2&ndash;4 days of treatment, and after 21&ndash;28 days of quetiapine treatment. The average dose of quetiapine was 155 mg, ranging from 100&ndash;200 mg.Results: Adjunctive quetiapine therapy did not significantly alter sleep efficiency, sleep continuity, or Pittsburgh Sleep Quality Index scores. Respiratory Disturbance Index and percentage of total time in rapid eye movement (REM) sleep significantly decreased and the percentage of total time in non-REM sleep, and duration of Stage 2 and non-REM sleep significantly increased after 2&ndash;4 days of quetiapine treatment. Illness severity significantly decreased over time.Conclusions: Adjunctive quetiapine treatment alters sleep architecture in patients with major depressive disorder or bipolar disorder, which may partially explain its early antidepressant properties. Changes in sleep architecture are more robust and significant within two to four days of starting treatment.Keywords: quetiapine, sleep architecture, depression, bipolar disorder
format	article
author	Laura Gedge Lauren Lazowski David Murray et al
author_facet	Laura Gedge Lauren Lazowski David Murray et al
author_sort	Laura Gedge
title	Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression
title_short	Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression
title_full	Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression
title_fullStr	Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression
title_full_unstemmed	Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression
title_sort	effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/0c28695ab8464d30a0f9ddfe301a4da1
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Effects of quetiapine on sleep architecture in patients with unipolar or bipolar depression

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