Antibacterial treatment of aspiration pneumonia in older people: a systematic review

Timra J Bowerman,1–3 Jan Zhang,2 Louise M Waite4,5 1Department of Aged Care, Psychogeriatrics and Rehabilitation, Bankstown-Lidcombe Hospital, Bankstown, NSW, Australia; 2Department of Geriatric Medicine, Concord Repatriation General Hospital, Concord, NSW, Australia; 3University of New S...

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Autores principales:	Bowerman TJ, Zhang J, Waite LM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	aspiration pneumonia antibiotics antibacterial antimicrobial older people Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/0c28cbc0738849e0b7277f4c51d1bc88
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spelling	oai:doaj.org-article:0c28cbc0738849e0b7277f4c51d1bc882021-12-02T01:58:45ZAntibacterial treatment of aspiration pneumonia in older people: a systematic review1178-1998https://doaj.org/article/0c28cbc0738849e0b7277f4c51d1bc882018-10-01T00:00:00Zhttps://www.dovepress.com/antibacterial-treatment-of-aspiration-pneumonia-in-older-people-a-syst-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Timra J Bowerman,1–3 Jan Zhang,2 Louise M Waite4,5 1Department of Aged Care, Psychogeriatrics and Rehabilitation, Bankstown-Lidcombe Hospital, Bankstown, NSW, Australia; 2Department of Geriatric Medicine, Concord Repatriation General Hospital, Concord, NSW, Australia; 3University of New South Wales, Sydney, NSW, Australia; 4Centre for Education and Research on Ageing, Concord Repatriation General Hospital, Concord, NSW, Australia; 5University of Sydney, Sydney, NSW, Australia Background: Aspiration pneumonia is a common problem in older people with high mortality and increasing prevalence.Objective: The aims of this paper were to systematically review the literature on the antibacterial treatment of aspiration pneumonia in elderly patients and identify the microbiology of aspiration pneumonia.Materials and methods: EMBASE, MEDLINE, and Cochrane databases were systematically searched for studies that examined the clinical efficacy of antibiotic treatment in elderly patients with aspiration pneumonia. Information on study design, antibiotic treatment, study population, participants, microbiology, clinical outcomes, adverse events, and mortality was recorded.Results: There were no definitive clinical trials, placebo-controlled trials, or meta-analyses. Of the eight studies selected for inclusion in the review, the majority utilized and/or compared broad-spectrum antibiotics. No specific antibacterial agent had evidence of superior efficacy. Broad-spectrum antibiotics resulted in the emergence of multiresistant organisms. Anaerobic bacteria were infrequently isolated, suggesting a less important role in the pathogenesis of aspiration pneumonia.Conclusion: There is limited evidence with regard to the use of antibiotics in older patients with aspiration pneumonia. Research providing an evidence base for the treatment of aspiration pneumonia in older people is required. Keywords: aspiration pneumonia, antibiotics, antibacterial, antimicrobial, older peopleBowerman TJZhang JWaite LMDove Medical Pressarticleaspiration pneumoniaantibioticsantibacterialantimicrobialolder peopleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 2201-2213 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	aspiration pneumonia antibiotics antibacterial antimicrobial older people Geriatrics RC952-954.6
spellingShingle	aspiration pneumonia antibiotics antibacterial antimicrobial older people Geriatrics RC952-954.6 Bowerman TJ Zhang J Waite LM Antibacterial treatment of aspiration pneumonia in older people: a systematic review
description	Timra J Bowerman,1–3 Jan Zhang,2 Louise M Waite4,5 1Department of Aged Care, Psychogeriatrics and Rehabilitation, Bankstown-Lidcombe Hospital, Bankstown, NSW, Australia; 2Department of Geriatric Medicine, Concord Repatriation General Hospital, Concord, NSW, Australia; 3University of New South Wales, Sydney, NSW, Australia; 4Centre for Education and Research on Ageing, Concord Repatriation General Hospital, Concord, NSW, Australia; 5University of Sydney, Sydney, NSW, Australia Background: Aspiration pneumonia is a common problem in older people with high mortality and increasing prevalence.Objective: The aims of this paper were to systematically review the literature on the antibacterial treatment of aspiration pneumonia in elderly patients and identify the microbiology of aspiration pneumonia.Materials and methods: EMBASE, MEDLINE, and Cochrane databases were systematically searched for studies that examined the clinical efficacy of antibiotic treatment in elderly patients with aspiration pneumonia. Information on study design, antibiotic treatment, study population, participants, microbiology, clinical outcomes, adverse events, and mortality was recorded.Results: There were no definitive clinical trials, placebo-controlled trials, or meta-analyses. Of the eight studies selected for inclusion in the review, the majority utilized and/or compared broad-spectrum antibiotics. No specific antibacterial agent had evidence of superior efficacy. Broad-spectrum antibiotics resulted in the emergence of multiresistant organisms. Anaerobic bacteria were infrequently isolated, suggesting a less important role in the pathogenesis of aspiration pneumonia.Conclusion: There is limited evidence with regard to the use of antibiotics in older patients with aspiration pneumonia. Research providing an evidence base for the treatment of aspiration pneumonia in older people is required. Keywords: aspiration pneumonia, antibiotics, antibacterial, antimicrobial, older people
format	article
author	Bowerman TJ Zhang J Waite LM
author_facet	Bowerman TJ Zhang J Waite LM
author_sort	Bowerman TJ
title	Antibacterial treatment of aspiration pneumonia in older people: a systematic review
title_short	Antibacterial treatment of aspiration pneumonia in older people: a systematic review
title_full	Antibacterial treatment of aspiration pneumonia in older people: a systematic review
title_fullStr	Antibacterial treatment of aspiration pneumonia in older people: a systematic review
title_full_unstemmed	Antibacterial treatment of aspiration pneumonia in older people: a systematic review
title_sort	antibacterial treatment of aspiration pneumonia in older people: a systematic review
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/0c28cbc0738849e0b7277f4c51d1bc88
work_keys_str_mv	AT bowermantj antibacterialtreatmentofaspirationpneumoniainolderpeopleasystematicreview AT zhangj antibacterialtreatmentofaspirationpneumoniainolderpeopleasystematicreview AT waitelm antibacterialtreatmentofaspirationpneumoniainolderpeopleasystematicreview
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Antibacterial treatment of aspiration pneumonia in older people: a systematic review

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