CORRELATION ANALYSIS BETWEEN LABORATORY IMMUNE AND METABOLIC PARAMETERS IN CHRONIC BRAIN ISCHEMIA STAGES I AND II ALONG WITH HYPERTENSION AFTER TREATMENT

Determination of interrelationships between impairments of laboratory parameters of immune and metabolic status in patients with chronic cerebral ischemia of I-II stages was carried out. The study included 104 patients, of which 76 were female and 28 males, with CCI on the background of II degree hy...

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Autores principales:	N. A. Bystrova, A. A. Shulginova, A. I. Konoplya
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2021
Materias:	chronic cerebral ischemia interrelationships of parameters of immunometabolic status Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/0c32eea8081b4fe1bbcd8c3b94631f17
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spelling	oai:doaj.org-article:0c32eea8081b4fe1bbcd8c3b94631f172021-11-18T08:03:51ZCORRELATION ANALYSIS BETWEEN LABORATORY IMMUNE AND METABOLIC PARAMETERS IN CHRONIC BRAIN ISCHEMIA STAGES I AND II ALONG WITH HYPERTENSION AFTER TREATMENT1563-06252313-741X10.15789/1563-0625-CAB-1992https://doaj.org/article/0c32eea8081b4fe1bbcd8c3b94631f172021-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1992https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XDetermination of interrelationships between impairments of laboratory parameters of immune and metabolic status in patients with chronic cerebral ischemia of I-II stages was carried out. The study included 104 patients, of which 76 were female and 28 males, with CCI on the background of II degree hypertension, of which 52 patients were with stage I and 52 with stage II at the age of 50 ± 5 years. Also, clinical and laboratory parameters were studied in 22 healthy donors of the same age. Evaluation of clinical and laboratory data was carried out at the beginning of treatment and 2 weeks after its end. The sorption capacity of erythrocytes and the sorption capacity of the glycocalyx (SEG), the activity of lipid peroxidation processes, the state of the antioxidant system were determined in blood plasma and erythrocytes, the level of stable metabolites of nitric oxide (SMNO), neopterin, C-reactive protein, cytokines (TNFα, IL- 1β, IL-8, IFNγ, IL-18, G-CSF, IL-4, IL-10), immunoglobulins (IgM, IgG, IgA), complement system components (C3, C4, C5, C5А), the phagocytic and oxygen-dependent activity of polymorphonuclear blood leukocytes. Comparative assessment of the results of correlation, factorial and cluster analyzes for assessing the parameters of the immune and metabolic status in patients with stage I CCI revealed the most significant laboratory parameters necessary for determination in the clinic for objective assessment of the severity of immune and metabolic disorders: TNFα, IL-8, IL-10, SMNO and NEG. In patients with CCI stage II, to objectively assess the severity of immune and metabolic disorders, TNFα, IL-8, IL-17, IL-10, the phagocytic number of neutrophils and SEG are recommended.N. A. BystrovaA. A. ShulginovaA. I. KonoplyaSPb RAACIarticlechronic cerebral ischemiainterrelationships of parameters of immunometabolic statusImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 23, Iss 4, Pp 737-742 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic cerebral ischemia interrelationships of parameters of immunometabolic status Immunologic diseases. Allergy RC581-607
spellingShingle	chronic cerebral ischemia interrelationships of parameters of immunometabolic status Immunologic diseases. Allergy RC581-607 N. A. Bystrova A. A. Shulginova A. I. Konoplya CORRELATION ANALYSIS BETWEEN LABORATORY IMMUNE AND METABOLIC PARAMETERS IN CHRONIC BRAIN ISCHEMIA STAGES I AND II ALONG WITH HYPERTENSION AFTER TREATMENT
description	Determination of interrelationships between impairments of laboratory parameters of immune and metabolic status in patients with chronic cerebral ischemia of I-II stages was carried out. The study included 104 patients, of which 76 were female and 28 males, with CCI on the background of II degree hypertension, of which 52 patients were with stage I and 52 with stage II at the age of 50 ± 5 years. Also, clinical and laboratory parameters were studied in 22 healthy donors of the same age. Evaluation of clinical and laboratory data was carried out at the beginning of treatment and 2 weeks after its end. The sorption capacity of erythrocytes and the sorption capacity of the glycocalyx (SEG), the activity of lipid peroxidation processes, the state of the antioxidant system were determined in blood plasma and erythrocytes, the level of stable metabolites of nitric oxide (SMNO), neopterin, C-reactive protein, cytokines (TNFα, IL- 1β, IL-8, IFNγ, IL-18, G-CSF, IL-4, IL-10), immunoglobulins (IgM, IgG, IgA), complement system components (C3, C4, C5, C5А), the phagocytic and oxygen-dependent activity of polymorphonuclear blood leukocytes. Comparative assessment of the results of correlation, factorial and cluster analyzes for assessing the parameters of the immune and metabolic status in patients with stage I CCI revealed the most significant laboratory parameters necessary for determination in the clinic for objective assessment of the severity of immune and metabolic disorders: TNFα, IL-8, IL-10, SMNO and NEG. In patients with CCI stage II, to objectively assess the severity of immune and metabolic disorders, TNFα, IL-8, IL-17, IL-10, the phagocytic number of neutrophils and SEG are recommended.
format	article
author	N. A. Bystrova A. A. Shulginova A. I. Konoplya
author_facet	N. A. Bystrova A. A. Shulginova A. I. Konoplya
author_sort	N. A. Bystrova
title	CORRELATION ANALYSIS BETWEEN LABORATORY IMMUNE AND METABOLIC PARAMETERS IN CHRONIC BRAIN ISCHEMIA STAGES I AND II ALONG WITH HYPERTENSION AFTER TREATMENT
title_short	CORRELATION ANALYSIS BETWEEN LABORATORY IMMUNE AND METABOLIC PARAMETERS IN CHRONIC BRAIN ISCHEMIA STAGES I AND II ALONG WITH HYPERTENSION AFTER TREATMENT
title_full	CORRELATION ANALYSIS BETWEEN LABORATORY IMMUNE AND METABOLIC PARAMETERS IN CHRONIC BRAIN ISCHEMIA STAGES I AND II ALONG WITH HYPERTENSION AFTER TREATMENT
title_fullStr	CORRELATION ANALYSIS BETWEEN LABORATORY IMMUNE AND METABOLIC PARAMETERS IN CHRONIC BRAIN ISCHEMIA STAGES I AND II ALONG WITH HYPERTENSION AFTER TREATMENT
title_full_unstemmed	CORRELATION ANALYSIS BETWEEN LABORATORY IMMUNE AND METABOLIC PARAMETERS IN CHRONIC BRAIN ISCHEMIA STAGES I AND II ALONG WITH HYPERTENSION AFTER TREATMENT
title_sort	correlation analysis between laboratory immune and metabolic parameters in chronic brain ischemia stages i and ii along with hypertension after treatment
publisher	SPb RAACI
publishDate	2021
url	https://doaj.org/article/0c32eea8081b4fe1bbcd8c3b94631f17
work_keys_str_mv	AT nabystrova correlationanalysisbetweenlaboratoryimmuneandmetabolicparametersinchronicbrainischemiastagesiandiialongwithhypertensionaftertreatment AT aashulginova correlationanalysisbetweenlaboratoryimmuneandmetabolicparametersinchronicbrainischemiastagesiandiialongwithhypertensionaftertreatment AT aikonoplya correlationanalysisbetweenlaboratoryimmuneandmetabolicparametersinchronicbrainischemiastagesiandiialongwithhypertensionaftertreatment
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CORRELATION ANALYSIS BETWEEN LABORATORY IMMUNE AND METABOLIC PARAMETERS IN CHRONIC BRAIN ISCHEMIA STAGES I AND II ALONG WITH HYPERTENSION AFTER TREATMENT

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