The granuloma in cryptococcal disease.

Although we have recognized cryptococcosis as a disease entity for well over 100 years, there are many details about its pathogenesis which remain unknown. A major barrier to better understanding is the very broad range of clinical and pathological forms cryptococcal infections can take. One such fo...

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Autores principales:	Laura C Ristow, J Muse Davis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0c34ab86f06041fdb51c29b4267c2087
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spelling	oai:doaj.org-article:0c34ab86f06041fdb51c29b4267c20872021-12-02T19:59:36ZThe granuloma in cryptococcal disease.1553-73661553-737410.1371/journal.ppat.1009342https://doaj.org/article/0c34ab86f06041fdb51c29b4267c20872021-03-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1009342https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Although we have recognized cryptococcosis as a disease entity for well over 100 years, there are many details about its pathogenesis which remain unknown. A major barrier to better understanding is the very broad range of clinical and pathological forms cryptococcal infections can take. One such form has been historically called the cryptococcal granuloma, or the cryptococcoma. These words have been used to describe essentially any mass lesion associated with infection, due to their presumed similarity to the quintessential granuloma, the tubercle in tuberculosis. Although clear distinctions between tuberculosis and cryptococcal disease have been discovered, cellular and molecular studies still confirm some important parallels between these 2 diseases and what we now call granulomatous inflammation. In this review, we shall sketch out some of the history behind the term "granuloma" as it pertains to cryptococcal disease, explore our current understanding of the biology of granuloma formation, and try to place that understanding in the context of the myriad pathological presentations of this infection. Finally, we shall summarize the role of the granuloma in cryptococcal latency and present opportunities for future investigations.Laura C RistowJ Muse DavisPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 3, p e1009342 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Laura C Ristow J Muse Davis The granuloma in cryptococcal disease.
description	Although we have recognized cryptococcosis as a disease entity for well over 100 years, there are many details about its pathogenesis which remain unknown. A major barrier to better understanding is the very broad range of clinical and pathological forms cryptococcal infections can take. One such form has been historically called the cryptococcal granuloma, or the cryptococcoma. These words have been used to describe essentially any mass lesion associated with infection, due to their presumed similarity to the quintessential granuloma, the tubercle in tuberculosis. Although clear distinctions between tuberculosis and cryptococcal disease have been discovered, cellular and molecular studies still confirm some important parallels between these 2 diseases and what we now call granulomatous inflammation. In this review, we shall sketch out some of the history behind the term "granuloma" as it pertains to cryptococcal disease, explore our current understanding of the biology of granuloma formation, and try to place that understanding in the context of the myriad pathological presentations of this infection. Finally, we shall summarize the role of the granuloma in cryptococcal latency and present opportunities for future investigations.
format	article
author	Laura C Ristow J Muse Davis
author_facet	Laura C Ristow J Muse Davis
author_sort	Laura C Ristow
title	The granuloma in cryptococcal disease.
title_short	The granuloma in cryptococcal disease.
title_full	The granuloma in cryptococcal disease.
title_fullStr	The granuloma in cryptococcal disease.
title_full_unstemmed	The granuloma in cryptococcal disease.
title_sort	granuloma in cryptococcal disease.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0c34ab86f06041fdb51c29b4267c2087
work_keys_str_mv	AT lauracristow thegranulomaincryptococcaldisease AT jmusedavis thegranulomaincryptococcaldisease AT lauracristow granulomaincryptococcaldisease AT jmusedavis granulomaincryptococcaldisease
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The granuloma in cryptococcal disease.

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