Risk factors for urosepsis in chronic kidney disease patients with urinary tract infections

Abstract Occurrence of urosepsis is not uncommon following urinary tract infections (UTI). However, there is a lack of evidence explaining the risk factors predisposing to urosepsis in patients with chronic kidney disease (CKD). This retrospective study was undertaken to evaluate the incidence and p...

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Autores principales:	Zorica Dimitrijevic, Goran Paunovic, Danijela Tasic, Branka Mitic, Dragoslav Basic
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0c36a759f94141e785dde0328c50b2d0
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spelling	oai:doaj.org-article:0c36a759f94141e785dde0328c50b2d02021-12-02T16:14:03ZRisk factors for urosepsis in chronic kidney disease patients with urinary tract infections10.1038/s41598-021-93912-32045-2322https://doaj.org/article/0c36a759f94141e785dde0328c50b2d02021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93912-3https://doaj.org/toc/2045-2322Abstract Occurrence of urosepsis is not uncommon following urinary tract infections (UTI). However, there is a lack of evidence explaining the risk factors predisposing to urosepsis in patients with chronic kidney disease (CKD). This retrospective study was undertaken to evaluate the incidence and possible risk factors for urosepsis among patients hospitalized with UTI in a cohort of CKD patients. Patients were divided into the urosepsis group and the non-urosepsis group. Of 489 hospitalized patients with UTI, 70 (14.3%) acquired urosepsis. Stepwise multivariate logistic regression demonstrated that diabetes, urinary catheter and length of hospital stay (p < 0.001 for all) were significant independent predictive risk factors for urosepsis in CKD patients with UTI in addition to age, glomerular filtration rate, hydronephrosis, acute kidney injury and E. coli infection (p < 0.05 for all). Finally, Klebsiella spp. cases were associated with significantly higher odds for urosepsis than E. coli cases (OR: 3.5, 95% CI: 2.86–7.23, p < 0.001 vs. OR: 1.38, 95% CI: 1.19–3.69, p = 0.038). Diabetes, presence of an indwelling urinary catheter, length of hospitalization, and infection with Klebsiella spp were independent risk factors for urosepsis in CKD patients with UTI.Zorica DimitrijevicGoran PaunovicDanijela TasicBranka MiticDragoslav BasicNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zorica Dimitrijevic Goran Paunovic Danijela Tasic Branka Mitic Dragoslav Basic Risk factors for urosepsis in chronic kidney disease patients with urinary tract infections
description	Abstract Occurrence of urosepsis is not uncommon following urinary tract infections (UTI). However, there is a lack of evidence explaining the risk factors predisposing to urosepsis in patients with chronic kidney disease (CKD). This retrospective study was undertaken to evaluate the incidence and possible risk factors for urosepsis among patients hospitalized with UTI in a cohort of CKD patients. Patients were divided into the urosepsis group and the non-urosepsis group. Of 489 hospitalized patients with UTI, 70 (14.3%) acquired urosepsis. Stepwise multivariate logistic regression demonstrated that diabetes, urinary catheter and length of hospital stay (p < 0.001 for all) were significant independent predictive risk factors for urosepsis in CKD patients with UTI in addition to age, glomerular filtration rate, hydronephrosis, acute kidney injury and E. coli infection (p < 0.05 for all). Finally, Klebsiella spp. cases were associated with significantly higher odds for urosepsis than E. coli cases (OR: 3.5, 95% CI: 2.86–7.23, p < 0.001 vs. OR: 1.38, 95% CI: 1.19–3.69, p = 0.038). Diabetes, presence of an indwelling urinary catheter, length of hospitalization, and infection with Klebsiella spp were independent risk factors for urosepsis in CKD patients with UTI.
format	article
author	Zorica Dimitrijevic Goran Paunovic Danijela Tasic Branka Mitic Dragoslav Basic
author_facet	Zorica Dimitrijevic Goran Paunovic Danijela Tasic Branka Mitic Dragoslav Basic
author_sort	Zorica Dimitrijevic
title	Risk factors for urosepsis in chronic kidney disease patients with urinary tract infections
title_short	Risk factors for urosepsis in chronic kidney disease patients with urinary tract infections
title_full	Risk factors for urosepsis in chronic kidney disease patients with urinary tract infections
title_fullStr	Risk factors for urosepsis in chronic kidney disease patients with urinary tract infections
title_full_unstemmed	Risk factors for urosepsis in chronic kidney disease patients with urinary tract infections
title_sort	risk factors for urosepsis in chronic kidney disease patients with urinary tract infections
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0c36a759f94141e785dde0328c50b2d0
work_keys_str_mv	AT zoricadimitrijevic riskfactorsforurosepsisinchronickidneydiseasepatientswithurinarytractinfections AT goranpaunovic riskfactorsforurosepsisinchronickidneydiseasepatientswithurinarytractinfections AT danijelatasic riskfactorsforurosepsisinchronickidneydiseasepatientswithurinarytractinfections AT brankamitic riskfactorsforurosepsisinchronickidneydiseasepatientswithurinarytractinfections AT dragoslavbasic riskfactorsforurosepsisinchronickidneydiseasepatientswithurinarytractinfections
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Risk factors for urosepsis in chronic kidney disease patients with urinary tract infections

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