The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections

Adenovirus (AdV) can cause persistent infections, but underlying mechanisms are poorly understood. Here, Prasad et al. show that the AdV glycoprotein E3-19K activates the unfolded protein response sensor IRE1α, and that this triggers a feedforward loop that sustains persistent infection in the prese...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Vibhu Prasad, Maarit Suomalainen, Yllza Jasiqi, Silvio Hemmi, Patrick Hearing, Louise Hosie, Hans-Gerhard Burgert, Urs F. Greber
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Q
Acceso en línea:https://doaj.org/article/0c377f65c8de48bc8b345b4796d48f32
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Adenovirus (AdV) can cause persistent infections, but underlying mechanisms are poorly understood. Here, Prasad et al. show that the AdV glycoprotein E3-19K activates the unfolded protein response sensor IRE1α, and that this triggers a feedforward loop that sustains persistent infection in the presence of interferon.