The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections

Adenovirus (AdV) can cause persistent infections, but underlying mechanisms are poorly understood. Here, Prasad et al. show that the AdV glycoprotein E3-19K activates the unfolded protein response sensor IRE1α, and that this triggers a feedforward loop that sustains persistent infection in the prese...

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Autores principales:	Vibhu Prasad, Maarit Suomalainen, Yllza Jasiqi, Silvio Hemmi, Patrick Hearing, Louise Hosie, Hans-Gerhard Burgert, Urs F. Greber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c377f65c8de48bc8b345b4796d48f32
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spelling	oai:doaj.org-article:0c377f65c8de48bc8b345b4796d48f322021-12-02T16:50:00ZThe UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections10.1038/s41467-020-15844-22041-1723https://doaj.org/article/0c377f65c8de48bc8b345b4796d48f322020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15844-2https://doaj.org/toc/2041-1723Adenovirus (AdV) can cause persistent infections, but underlying mechanisms are poorly understood. Here, Prasad et al. show that the AdV glycoprotein E3-19K activates the unfolded protein response sensor IRE1α, and that this triggers a feedforward loop that sustains persistent infection in the presence of interferon.Vibhu PrasadMaarit SuomalainenYllza JasiqiSilvio HemmiPatrick HearingLouise HosieHans-Gerhard BurgertUrs F. GreberNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vibhu Prasad Maarit Suomalainen Yllza Jasiqi Silvio Hemmi Patrick Hearing Louise Hosie Hans-Gerhard Burgert Urs F. Greber The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections
description	Adenovirus (AdV) can cause persistent infections, but underlying mechanisms are poorly understood. Here, Prasad et al. show that the AdV glycoprotein E3-19K activates the unfolded protein response sensor IRE1α, and that this triggers a feedforward loop that sustains persistent infection in the presence of interferon.
format	article
author	Vibhu Prasad Maarit Suomalainen Yllza Jasiqi Silvio Hemmi Patrick Hearing Louise Hosie Hans-Gerhard Burgert Urs F. Greber
author_facet	Vibhu Prasad Maarit Suomalainen Yllza Jasiqi Silvio Hemmi Patrick Hearing Louise Hosie Hans-Gerhard Burgert Urs F. Greber
author_sort	Vibhu Prasad
title	The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections
title_short	The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections
title_full	The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections
title_fullStr	The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections
title_full_unstemmed	The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections
title_sort	upr sensor ire1α and the adenovirus e3-19k glycoprotein sustain persistent and lytic infections
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0c377f65c8de48bc8b345b4796d48f32
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The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections

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