Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1

Pericytes are essential for the development, maintenance and function of vascular networks. Here, Eilken and colleagues show that expression of the decoy receptor VEGFR1 by pericytes spatially restricts VEGF signalling, thus regulating VEGF-induced endothelial cell sprouting in developing tissues.

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Autores principales:	Hanna M. Eilken, Rodrigo Diéguez-Hurtado, Inga Schmidt, Masanori Nakayama, Hyun-Woo Jeong, Hendrik Arf, Susanne Adams, Napoleone Ferrara, Ralf H. Adams
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c3a3cf9ba3b4c24826d8cf136e3439f
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spelling	oai:doaj.org-article:0c3a3cf9ba3b4c24826d8cf136e3439f2021-12-02T17:06:14ZPericytes regulate VEGF-induced endothelial sprouting through VEGFR110.1038/s41467-017-01738-32041-1723https://doaj.org/article/0c3a3cf9ba3b4c24826d8cf136e3439f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01738-3https://doaj.org/toc/2041-1723Pericytes are essential for the development, maintenance and function of vascular networks. Here, Eilken and colleagues show that expression of the decoy receptor VEGFR1 by pericytes spatially restricts VEGF signalling, thus regulating VEGF-induced endothelial cell sprouting in developing tissues.Hanna M. EilkenRodrigo Diéguez-HurtadoInga SchmidtMasanori NakayamaHyun-Woo JeongHendrik ArfSusanne AdamsNapoleone FerraraRalf H. AdamsNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hanna M. Eilken Rodrigo Diéguez-Hurtado Inga Schmidt Masanori Nakayama Hyun-Woo Jeong Hendrik Arf Susanne Adams Napoleone Ferrara Ralf H. Adams Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1
description	Pericytes are essential for the development, maintenance and function of vascular networks. Here, Eilken and colleagues show that expression of the decoy receptor VEGFR1 by pericytes spatially restricts VEGF signalling, thus regulating VEGF-induced endothelial cell sprouting in developing tissues.
format	article
author	Hanna M. Eilken Rodrigo Diéguez-Hurtado Inga Schmidt Masanori Nakayama Hyun-Woo Jeong Hendrik Arf Susanne Adams Napoleone Ferrara Ralf H. Adams
author_facet	Hanna M. Eilken Rodrigo Diéguez-Hurtado Inga Schmidt Masanori Nakayama Hyun-Woo Jeong Hendrik Arf Susanne Adams Napoleone Ferrara Ralf H. Adams
author_sort	Hanna M. Eilken
title	Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1
title_short	Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1
title_full	Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1
title_fullStr	Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1
title_full_unstemmed	Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1
title_sort	pericytes regulate vegf-induced endothelial sprouting through vegfr1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0c3a3cf9ba3b4c24826d8cf136e3439f
work_keys_str_mv	AT hannameilken pericytesregulatevegfinducedendothelialsproutingthroughvegfr1 AT rodrigodieguezhurtado pericytesregulatevegfinducedendothelialsproutingthroughvegfr1 AT ingaschmidt pericytesregulatevegfinducedendothelialsproutingthroughvegfr1 AT masanorinakayama pericytesregulatevegfinducedendothelialsproutingthroughvegfr1 AT hyunwoojeong pericytesregulatevegfinducedendothelialsproutingthroughvegfr1 AT hendrikarf pericytesregulatevegfinducedendothelialsproutingthroughvegfr1 AT susanneadams pericytesregulatevegfinducedendothelialsproutingthroughvegfr1 AT napoleoneferrara pericytesregulatevegfinducedendothelialsproutingthroughvegfr1 AT ralfhadams pericytesregulatevegfinducedendothelialsproutingthroughvegfr1
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Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1

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