Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene
The Eμ-Myc lymphoma mouse model has been invaluable in the study of this disease. Here, the authors use multiple sequencing strategies to analyse the tumours in these mice and find recurrent inactivating mutations in Bcor, suggesting that this gene has a negative role in Mycsignalling.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/0c3aa501a43e4f4f934206118b33d4f2 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:0c3aa501a43e4f4f934206118b33d4f2 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:0c3aa501a43e4f4f934206118b33d4f22021-12-02T14:41:09ZGenomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene10.1038/ncomms145812041-1723https://doaj.org/article/0c3aa501a43e4f4f934206118b33d4f22017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14581https://doaj.org/toc/2041-1723The Eμ-Myc lymphoma mouse model has been invaluable in the study of this disease. Here, the authors use multiple sequencing strategies to analyse the tumours in these mice and find recurrent inactivating mutations in Bcor, suggesting that this gene has a negative role in Mycsignalling.Marcus LefebureRichard W. TothillElizabeth KruseEdwin D. HawkinsJake ShorttGeoffrey M. MatthewsGareth P. GregoryBenjamin P. MartinMadison J. KellyIzabela TodorovskiMaria A. DoyleRichard LupatJason LiJan SchroederMeaghan WallStuart CraigGretchen PoortingaDon CameronMegan BywaterLev KatsMicah D. GearhartVivian J. BardwellRoss A. DickinsRoss D. HannanAnthony T. PapenfussRicky W. JohnstoneNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Marcus Lefebure Richard W. Tothill Elizabeth Kruse Edwin D. Hawkins Jake Shortt Geoffrey M. Matthews Gareth P. Gregory Benjamin P. Martin Madison J. Kelly Izabela Todorovski Maria A. Doyle Richard Lupat Jason Li Jan Schroeder Meaghan Wall Stuart Craig Gretchen Poortinga Don Cameron Megan Bywater Lev Kats Micah D. Gearhart Vivian J. Bardwell Ross A. Dickins Ross D. Hannan Anthony T. Papenfuss Ricky W. Johnstone Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene |
| description |
The Eμ-Myc lymphoma mouse model has been invaluable in the study of this disease. Here, the authors use multiple sequencing strategies to analyse the tumours in these mice and find recurrent inactivating mutations in Bcor, suggesting that this gene has a negative role in Mycsignalling. |
| format |
article |
| author |
Marcus Lefebure Richard W. Tothill Elizabeth Kruse Edwin D. Hawkins Jake Shortt Geoffrey M. Matthews Gareth P. Gregory Benjamin P. Martin Madison J. Kelly Izabela Todorovski Maria A. Doyle Richard Lupat Jason Li Jan Schroeder Meaghan Wall Stuart Craig Gretchen Poortinga Don Cameron Megan Bywater Lev Kats Micah D. Gearhart Vivian J. Bardwell Ross A. Dickins Ross D. Hannan Anthony T. Papenfuss Ricky W. Johnstone |
| author_facet |
Marcus Lefebure Richard W. Tothill Elizabeth Kruse Edwin D. Hawkins Jake Shortt Geoffrey M. Matthews Gareth P. Gregory Benjamin P. Martin Madison J. Kelly Izabela Todorovski Maria A. Doyle Richard Lupat Jason Li Jan Schroeder Meaghan Wall Stuart Craig Gretchen Poortinga Don Cameron Megan Bywater Lev Kats Micah D. Gearhart Vivian J. Bardwell Ross A. Dickins Ross D. Hannan Anthony T. Papenfuss Ricky W. Johnstone |
| author_sort |
Marcus Lefebure |
| title |
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene |
| title_short |
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene |
| title_full |
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene |
| title_fullStr |
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene |
| title_full_unstemmed |
Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene |
| title_sort |
genomic characterisation of eμ-myc mouse lymphomas identifies bcor as a myc co-operative tumour-suppressor gene |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/0c3aa501a43e4f4f934206118b33d4f2 |
| work_keys_str_mv |
AT marcuslefebure genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT richardwtothill genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT elizabethkruse genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT edwindhawkins genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT jakeshortt genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT geoffreymmatthews genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT garethpgregory genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT benjaminpmartin genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT madisonjkelly genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT izabelatodorovski genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT mariaadoyle genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT richardlupat genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT jasonli genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT janschroeder genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT meaghanwall genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT stuartcraig genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT gretchenpoortinga genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT doncameron genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT meganbywater genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT levkats genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT micahdgearhart genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT vivianjbardwell genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT rossadickins genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT rossdhannan genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT anthonytpapenfuss genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene AT rickywjohnstone genomiccharacterisationofemmycmouselymphomasidentifiesbcorasamyccooperativetumoursuppressorgene |
| _version_ |
1718389973898493952 |