Relation between NOD2 genotype and changes in innate signaling in Crohn’s disease on mRNA and miRNA levels

Crohn’s disease: Genetics impacts molecular regulation of innate immunity on miRNA, but not gene level The genetics of people with Crohn’s disease affects the molecular drivers of their dysregulated immune responses. Some individuals with Crohn’s harbor mutations in the NOD2 gene, which encodes a pa...

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Autores principales:	Yun Chen, Mohammad Salem, Mette Boyd, Jette Bornholdt, Yuan Li, Mehmet Coskun, Jakob Benedict Seidelin, Albin Sandelin, Ole Haagen Nielsen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Genetics QH426-470
Acceso en línea:	https://doaj.org/article/0c3aa70004c34b6cb6b843de4dde0a99
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spelling	oai:doaj.org-article:0c3aa70004c34b6cb6b843de4dde0a992021-12-02T12:34:18ZRelation between NOD2 genotype and changes in innate signaling in Crohn’s disease on mRNA and miRNA levels10.1038/s41525-016-0001-42056-7944https://doaj.org/article/0c3aa70004c34b6cb6b843de4dde0a992017-02-01T00:00:00Zhttps://doi.org/10.1038/s41525-016-0001-4https://doaj.org/toc/2056-7944Crohn’s disease: Genetics impacts molecular regulation of innate immunity on miRNA, but not gene level The genetics of people with Crohn’s disease affects the molecular drivers of their dysregulated immune responses. Some individuals with Crohn’s harbor mutations in the NOD2 gene, which encodes a pathogen recognition receptor that binds to a molecule called muramyl dipeptide (MDP). To better understand how alternations in NOD2 can lead to increased susceptibility to gut inflammation, Yun Chen, Mohammad Salem and colleagues from the University of Copenhagen and Herlev Hospital, Denmark, analyzed the expression patterns of both genes and small, regulatory microRNAs in blood cells from healthy controls and from Crohn’s patients with and without NOD2 mutations. They exposed the cells to MDP, and saw that although gene acticity changed dramatically as a response, there was little difference between subjects, regardless of genetics. Conversely, microRNA expression showed genotype-specific differences that weren not impacted by MDP treatment. The findings underscore the importance of microRNAs in Crohn’s disease.Yun ChenMohammad SalemMette BoydJette BornholdtYuan LiMehmet CoskunJakob Benedict SeidelinAlbin SandelinOle Haagen NielsenNature PortfolioarticleMedicineRGeneticsQH426-470ENnpj Genomic Medicine, Vol 2, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Genetics QH426-470
spellingShingle	Medicine R Genetics QH426-470 Yun Chen Mohammad Salem Mette Boyd Jette Bornholdt Yuan Li Mehmet Coskun Jakob Benedict Seidelin Albin Sandelin Ole Haagen Nielsen Relation between NOD2 genotype and changes in innate signaling in Crohn’s disease on mRNA and miRNA levels
description	Crohn’s disease: Genetics impacts molecular regulation of innate immunity on miRNA, but not gene level The genetics of people with Crohn’s disease affects the molecular drivers of their dysregulated immune responses. Some individuals with Crohn’s harbor mutations in the NOD2 gene, which encodes a pathogen recognition receptor that binds to a molecule called muramyl dipeptide (MDP). To better understand how alternations in NOD2 can lead to increased susceptibility to gut inflammation, Yun Chen, Mohammad Salem and colleagues from the University of Copenhagen and Herlev Hospital, Denmark, analyzed the expression patterns of both genes and small, regulatory microRNAs in blood cells from healthy controls and from Crohn’s patients with and without NOD2 mutations. They exposed the cells to MDP, and saw that although gene acticity changed dramatically as a response, there was little difference between subjects, regardless of genetics. Conversely, microRNA expression showed genotype-specific differences that weren not impacted by MDP treatment. The findings underscore the importance of microRNAs in Crohn’s disease.
format	article
author	Yun Chen Mohammad Salem Mette Boyd Jette Bornholdt Yuan Li Mehmet Coskun Jakob Benedict Seidelin Albin Sandelin Ole Haagen Nielsen
author_facet	Yun Chen Mohammad Salem Mette Boyd Jette Bornholdt Yuan Li Mehmet Coskun Jakob Benedict Seidelin Albin Sandelin Ole Haagen Nielsen
author_sort	Yun Chen
title	Relation between NOD2 genotype and changes in innate signaling in Crohn’s disease on mRNA and miRNA levels
title_short	Relation between NOD2 genotype and changes in innate signaling in Crohn’s disease on mRNA and miRNA levels
title_full	Relation between NOD2 genotype and changes in innate signaling in Crohn’s disease on mRNA and miRNA levels
title_fullStr	Relation between NOD2 genotype and changes in innate signaling in Crohn’s disease on mRNA and miRNA levels
title_full_unstemmed	Relation between NOD2 genotype and changes in innate signaling in Crohn’s disease on mRNA and miRNA levels
title_sort	relation between nod2 genotype and changes in innate signaling in crohn’s disease on mrna and mirna levels
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0c3aa70004c34b6cb6b843de4dde0a99
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Relation between NOD2 genotype and changes in innate signaling in Crohn’s disease on mRNA and miRNA levels

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