Characterization of nanostructured ureteral stent with gradient degradation in a porcine model

Xiaoqing Wang,1 Hongli Shan,2 Jixue Wang,1 Yuchuan Hou,1 Jianxun Ding,3 Qihui Chen,1 Jingjing Guan,1 Chunxi Wang,1 Xuesi Chen31Department of Urology, the First Hospital of Jilin University, 2Department of Clinical Laboratory, the First Hospital of Jilin University, 3Key Laboratory of Polymer Ecomate...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang XQ, Shan HL, Wang JX, Hou YC, Ding JX, Chen QH, Guan JJ, Wang CX, Chen XS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0c3c82efe88340dcb40ebb8e4c9ca82e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0c3c82efe88340dcb40ebb8e4c9ca82e
record_format	dspace
spelling	oai:doaj.org-article:0c3c82efe88340dcb40ebb8e4c9ca82e2021-12-02T06:33:29ZCharacterization of nanostructured ureteral stent with gradient degradation in a porcine model1178-2013https://doaj.org/article/0c3c82efe88340dcb40ebb8e4c9ca82e2015-04-01T00:00:00Zhttp://www.dovepress.com/characterization-of-nanostructured-ureteral-stent-with-gradient-degrad-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiaoqing Wang,1 Hongli Shan,2 Jixue Wang,1 Yuchuan Hou,1 Jianxun Ding,3 Qihui Chen,1 Jingjing Guan,1 Chunxi Wang,1 Xuesi Chen31Department of Urology, the First Hospital of Jilin University, 2Department of Clinical Laboratory, the First Hospital of Jilin University, 3Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, People’s Republic of ChinaAbstract: A tubular poly(ε-caprolactone) (PCL)/poly(lactide-co-glycolide) (PLGA) ureteral stent composed of nanofibers with micropores was fabricated by double-needle electrospinning. The stent was ureteroscopically inserted into six Changbai pigs, and the commercial polyurethane Shagong® stent was inserted into four pigs as control. Intravenous pyelography revealed that the PCL/PLGA stent gradually degraded from the distal end to proximal terminal, and all stents were completely degraded at 10 weeks post-insertion. No significant difference was observed in hydronephrosis severity between the two groups. The levels of serum creatinine and urine pH remained similar throughout the study in the two groups, but the number of white blood cells in the urine was significantly higher in the Shagong® stent group. On Day 70, histological evaluation indicated equivalent histological severity scores in the middle and distal ureter sections and bladder in the two groups. However, the PCL/PLGA stent-implanted pigs had significantly lower mean severity scores in the kidney and proximal ureter sites. These data revealed that the PCL/PLGA stent degraded in a controlled manner, did not induce obstruction, and had a lower urothelial impact in comparison to the Shagong® stent, indicating that the stent exhibited great potential for clinical application.Keywords: nanocomposites, polyesters, poly(ε-caprolactone), poly(lactide-co-glycolide), hydronephrosis severityWang XQShan HLWang JXHou YCDing JXChen QHGuan JJWang CXChen XSDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 3055-3064 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wang XQ Shan HL Wang JX Hou YC Ding JX Chen QH Guan JJ Wang CX Chen XS Characterization of nanostructured ureteral stent with gradient degradation in a porcine model
description	Xiaoqing Wang,1 Hongli Shan,2 Jixue Wang,1 Yuchuan Hou,1 Jianxun Ding,3 Qihui Chen,1 Jingjing Guan,1 Chunxi Wang,1 Xuesi Chen31Department of Urology, the First Hospital of Jilin University, 2Department of Clinical Laboratory, the First Hospital of Jilin University, 3Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, People’s Republic of ChinaAbstract: A tubular poly(ε-caprolactone) (PCL)/poly(lactide-co-glycolide) (PLGA) ureteral stent composed of nanofibers with micropores was fabricated by double-needle electrospinning. The stent was ureteroscopically inserted into six Changbai pigs, and the commercial polyurethane Shagong® stent was inserted into four pigs as control. Intravenous pyelography revealed that the PCL/PLGA stent gradually degraded from the distal end to proximal terminal, and all stents were completely degraded at 10 weeks post-insertion. No significant difference was observed in hydronephrosis severity between the two groups. The levels of serum creatinine and urine pH remained similar throughout the study in the two groups, but the number of white blood cells in the urine was significantly higher in the Shagong® stent group. On Day 70, histological evaluation indicated equivalent histological severity scores in the middle and distal ureter sections and bladder in the two groups. However, the PCL/PLGA stent-implanted pigs had significantly lower mean severity scores in the kidney and proximal ureter sites. These data revealed that the PCL/PLGA stent degraded in a controlled manner, did not induce obstruction, and had a lower urothelial impact in comparison to the Shagong® stent, indicating that the stent exhibited great potential for clinical application.Keywords: nanocomposites, polyesters, poly(ε-caprolactone), poly(lactide-co-glycolide), hydronephrosis severity
format	article
author	Wang XQ Shan HL Wang JX Hou YC Ding JX Chen QH Guan JJ Wang CX Chen XS
author_facet	Wang XQ Shan HL Wang JX Hou YC Ding JX Chen QH Guan JJ Wang CX Chen XS
author_sort	Wang XQ
title	Characterization of nanostructured ureteral stent with gradient degradation in a porcine model
title_short	Characterization of nanostructured ureteral stent with gradient degradation in a porcine model
title_full	Characterization of nanostructured ureteral stent with gradient degradation in a porcine model
title_fullStr	Characterization of nanostructured ureteral stent with gradient degradation in a porcine model
title_full_unstemmed	Characterization of nanostructured ureteral stent with gradient degradation in a porcine model
title_sort	characterization of nanostructured ureteral stent with gradient degradation in a porcine model
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/0c3c82efe88340dcb40ebb8e4c9ca82e
work_keys_str_mv	AT wangxq characterizationofnanostructuredureteralstentwithgradientdegradationinaporcinemodel AT shanhl characterizationofnanostructuredureteralstentwithgradientdegradationinaporcinemodel AT wangjx characterizationofnanostructuredureteralstentwithgradientdegradationinaporcinemodel AT houyc characterizationofnanostructuredureteralstentwithgradientdegradationinaporcinemodel AT dingjx characterizationofnanostructuredureteralstentwithgradientdegradationinaporcinemodel AT chenqh characterizationofnanostructuredureteralstentwithgradientdegradationinaporcinemodel AT guanjj characterizationofnanostructuredureteralstentwithgradientdegradationinaporcinemodel AT wangcx characterizationofnanostructuredureteralstentwithgradientdegradationinaporcinemodel AT chenxs characterizationofnanostructuredureteralstentwithgradientdegradationinaporcinemodel
_version_	1718399855837052928

Characterization of nanostructured ureteral stent with gradient degradation in a porcine model

Ejemplares similares