Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche

How the environment of the niche regulates haematopoietic stem cells (HSC) is unclear. Here, the authors identify a mesenchymal stromal progenitor hierarchy and identify Sca1+ cells as common progenitors for mesenchymal stromal cells in the adult niche that provide a supportive environment for hemat...

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Autores principales: Xingbin Hu, Mayra Garcia, Lihong Weng, Xiaoman Jung, Jodi L. Murakami, Bijender Kumar, Charles D. Warden, Ivan Todorov, Ching-Cheng Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/0c3e26f6e868438cbe5484c31c1ee35f
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Sumario:How the environment of the niche regulates haematopoietic stem cells (HSC) is unclear. Here, the authors identify a mesenchymal stromal progenitor hierarchy and identify Sca1+ cells as common progenitors for mesenchymal stromal cells in the adult niche that provide a supportive environment for hematopoiesis.