Type 2 diabetes and psoriasis: links and risks

Jesper Grønlund Holm,1 Simon Francis Thomsen1,2 1Department of Dermato-Venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; 2Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Abstract: Psori...

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Autores principales:	Holm JG, Thomsen SF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Psoriasis type-2-diabetes association risk link Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/0c44d673418b43839ecdd07d1d4864b6
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spelling	oai:doaj.org-article:0c44d673418b43839ecdd07d1d4864b62021-12-02T06:06:43ZType 2 diabetes and psoriasis: links and risks2230-326Xhttps://doaj.org/article/0c44d673418b43839ecdd07d1d4864b62019-01-01T00:00:00Zhttps://www.dovepress.com/type-2-diabetes-and-psoriasis-links-and-risks-peer-reviewed-article-PTThttps://doaj.org/toc/2230-326XJesper Grønlund Holm,1 Simon Francis Thomsen1,2 1Department of Dermato-Venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; 2Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Abstract: Psoriasis (PsO) is one of the most common chronic inflammatory skin diseases with a world prevalence of 2%–4%. The increasing knowledge of the mechanisms driving PsO has raised focus on existing links to metabolic syndrome and type 2 diabetes (T2D). We reviewed the existing literature of the prevalence and risk of T2D in patients with PsO. The studies reviewed were mainly large retrospective cohort and case–control studies, showing an increased prevalence of T2D in PsO patients compared to controls, particularly in late onset (type 2) PsO. T2D prevalence did not correlate to patient age or severity of PsO in the reviewed studies. Conclusively, T2D was found to be more prevalent in patients with PsO compared to the background population. Several mechanisms involved in lipid transportation seem to be upregulated in PsO patients. Physicians play a key role concerning information about known comorbidity and promotion of early prophylaxis in patients with PsO. Keywords: psoriasis, type 2 diabetes, association, risk, linkHolm JGThomsen SFDove Medical PressarticlePsoriasistype-2-diabetesassociationrisklinkDermatologyRL1-803ENPsoriasis: Targets and Therapy, Vol Volume 9, Pp 1-6 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psoriasis type-2-diabetes association risk link Dermatology RL1-803
spellingShingle	Psoriasis type-2-diabetes association risk link Dermatology RL1-803 Holm JG Thomsen SF Type 2 diabetes and psoriasis: links and risks
description	Jesper Grønlund Holm,1 Simon Francis Thomsen1,2 1Department of Dermato-Venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark; 2Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Abstract: Psoriasis (PsO) is one of the most common chronic inflammatory skin diseases with a world prevalence of 2%–4%. The increasing knowledge of the mechanisms driving PsO has raised focus on existing links to metabolic syndrome and type 2 diabetes (T2D). We reviewed the existing literature of the prevalence and risk of T2D in patients with PsO. The studies reviewed were mainly large retrospective cohort and case–control studies, showing an increased prevalence of T2D in PsO patients compared to controls, particularly in late onset (type 2) PsO. T2D prevalence did not correlate to patient age or severity of PsO in the reviewed studies. Conclusively, T2D was found to be more prevalent in patients with PsO compared to the background population. Several mechanisms involved in lipid transportation seem to be upregulated in PsO patients. Physicians play a key role concerning information about known comorbidity and promotion of early prophylaxis in patients with PsO. Keywords: psoriasis, type 2 diabetes, association, risk, link
format	article
author	Holm JG Thomsen SF
author_facet	Holm JG Thomsen SF
author_sort	Holm JG
title	Type 2 diabetes and psoriasis: links and risks
title_short	Type 2 diabetes and psoriasis: links and risks
title_full	Type 2 diabetes and psoriasis: links and risks
title_fullStr	Type 2 diabetes and psoriasis: links and risks
title_full_unstemmed	Type 2 diabetes and psoriasis: links and risks
title_sort	type 2 diabetes and psoriasis: links and risks
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/0c44d673418b43839ecdd07d1d4864b6
work_keys_str_mv	AT holmjg type2diabetesandpsoriasislinksandrisks AT thomsensf type2diabetesandpsoriasislinksandrisks
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Type 2 diabetes and psoriasis: links and risks

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