Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease
Zika virus infection of pregnant women can cause congenital brain defects. Here, Coffey et al. establish a pregnant rhesus macaque model, using intravenous and intraamniotic route of infection, that reliably reproduces fetal neurologic defects of congenital Zika syndrome in humans.
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Nature Portfolio
2018
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oai:doaj.org-article:0c47a3f0b9ab40999b9779d3fa59c1c92021-12-02T16:49:17ZIntraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease10.1038/s41467-018-04777-62041-1723https://doaj.org/article/0c47a3f0b9ab40999b9779d3fa59c1c92018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04777-6https://doaj.org/toc/2041-1723Zika virus infection of pregnant women can cause congenital brain defects. Here, Coffey et al. establish a pregnant rhesus macaque model, using intravenous and intraamniotic route of infection, that reliably reproduces fetal neurologic defects of congenital Zika syndrome in humans.Lark L. CoffeyRebekah I. KeeslerPatricia A. PesaventoKevin WoolardAnil SingapuriJennifer WatanabeChristina CruzenKari L. ChristeJodie UsachenkoJoAnn YeeVictoria A. HengEliza Bliss-MoreauJ. Rachel ReaderWilhelm von MorgenlandAnne M. GibbonsKenneth JacksonAmir ArdeshirHolly HeimsathSallie PermarParanthaman SenthamaraikannanPietro PresicceSuhas G. KallapurJeffrey M. LinnenKui GaoRobert OrrTracy MacGillMichelle McClureRichard McFarlandJohn H. MorrisonKoen K. A. Van RompayNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Lark L. Coffey Rebekah I. Keesler Patricia A. Pesavento Kevin Woolard Anil Singapuri Jennifer Watanabe Christina Cruzen Kari L. Christe Jodie Usachenko JoAnn Yee Victoria A. Heng Eliza Bliss-Moreau J. Rachel Reader Wilhelm von Morgenland Anne M. Gibbons Kenneth Jackson Amir Ardeshir Holly Heimsath Sallie Permar Paranthaman Senthamaraikannan Pietro Presicce Suhas G. Kallapur Jeffrey M. Linnen Kui Gao Robert Orr Tracy MacGill Michelle McClure Richard McFarland John H. Morrison Koen K. A. Van Rompay Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease |
| description |
Zika virus infection of pregnant women can cause congenital brain defects. Here, Coffey et al. establish a pregnant rhesus macaque model, using intravenous and intraamniotic route of infection, that reliably reproduces fetal neurologic defects of congenital Zika syndrome in humans. |
| format |
article |
| author |
Lark L. Coffey Rebekah I. Keesler Patricia A. Pesavento Kevin Woolard Anil Singapuri Jennifer Watanabe Christina Cruzen Kari L. Christe Jodie Usachenko JoAnn Yee Victoria A. Heng Eliza Bliss-Moreau J. Rachel Reader Wilhelm von Morgenland Anne M. Gibbons Kenneth Jackson Amir Ardeshir Holly Heimsath Sallie Permar Paranthaman Senthamaraikannan Pietro Presicce Suhas G. Kallapur Jeffrey M. Linnen Kui Gao Robert Orr Tracy MacGill Michelle McClure Richard McFarland John H. Morrison Koen K. A. Van Rompay |
| author_facet |
Lark L. Coffey Rebekah I. Keesler Patricia A. Pesavento Kevin Woolard Anil Singapuri Jennifer Watanabe Christina Cruzen Kari L. Christe Jodie Usachenko JoAnn Yee Victoria A. Heng Eliza Bliss-Moreau J. Rachel Reader Wilhelm von Morgenland Anne M. Gibbons Kenneth Jackson Amir Ardeshir Holly Heimsath Sallie Permar Paranthaman Senthamaraikannan Pietro Presicce Suhas G. Kallapur Jeffrey M. Linnen Kui Gao Robert Orr Tracy MacGill Michelle McClure Richard McFarland John H. Morrison Koen K. A. Van Rompay |
| author_sort |
Lark L. Coffey |
| title |
Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease |
| title_short |
Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease |
| title_full |
Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease |
| title_fullStr |
Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease |
| title_full_unstemmed |
Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease |
| title_sort |
intraamniotic zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/0c47a3f0b9ab40999b9779d3fa59c1c9 |
| work_keys_str_mv |
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