Feasibility of free-breathing quantitative myocardial perfusion using multi-echo Dixon magnetic resonance imaging

Abstract Dynamic contrast-enhanced quantitative first-pass perfusion using magnetic resonance imaging enables non-invasive objective assessment of myocardial ischemia without ionizing radiation. However, quantification of perfusion is challenging due to the non-linearity between the magnetic resonan...

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Autores principales:	Cian M. Scannell, Teresa Correia, Adriana D. M. Villa, Torben Schneider, Jack Lee, Marcel Breeuwer, Amedeo Chiribiri, Markus Henningsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0c4aa488d2e746cba86f4b91a1eaf185
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spelling	oai:doaj.org-article:0c4aa488d2e746cba86f4b91a1eaf1852021-12-02T16:06:40ZFeasibility of free-breathing quantitative myocardial perfusion using multi-echo Dixon magnetic resonance imaging10.1038/s41598-020-69747-92045-2322https://doaj.org/article/0c4aa488d2e746cba86f4b91a1eaf1852020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-69747-9https://doaj.org/toc/2045-2322Abstract Dynamic contrast-enhanced quantitative first-pass perfusion using magnetic resonance imaging enables non-invasive objective assessment of myocardial ischemia without ionizing radiation. However, quantification of perfusion is challenging due to the non-linearity between the magnetic resonance signal intensity and contrast agent concentration. Furthermore, respiratory motion during data acquisition precludes quantification of perfusion. While motion correction techniques have been proposed, they have been hampered by the challenge of accounting for dramatic contrast changes during the bolus and long execution times. In this work we investigate the use of a novel free-breathing multi-echo Dixon technique for quantitative myocardial perfusion. The Dixon fat images, unaffected by the dynamic contrast-enhancement, are used to efficiently estimate rigid-body respiratory motion and the computed transformations are applied to the corresponding diagnostic water images. This is followed by a second non-linear correction step using the Dixon water images to remove residual motion. The proposed Dixon motion correction technique was compared to the state-of-the-art technique (spatiotemporal based registration). We demonstrate that the proposed method performs comparably to the state-of-the-art but is significantly faster to execute. Furthermore, the proposed technique can be used to correct for the decay of signal due to T2* effects to improve quantification and additionally, yields fat-free diagnostic images.Cian M. ScannellTeresa CorreiaAdriana D. M. VillaTorben SchneiderJack LeeMarcel BreeuwerAmedeo ChiribiriMarkus HenningssonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cian M. Scannell Teresa Correia Adriana D. M. Villa Torben Schneider Jack Lee Marcel Breeuwer Amedeo Chiribiri Markus Henningsson Feasibility of free-breathing quantitative myocardial perfusion using multi-echo Dixon magnetic resonance imaging
description	Abstract Dynamic contrast-enhanced quantitative first-pass perfusion using magnetic resonance imaging enables non-invasive objective assessment of myocardial ischemia without ionizing radiation. However, quantification of perfusion is challenging due to the non-linearity between the magnetic resonance signal intensity and contrast agent concentration. Furthermore, respiratory motion during data acquisition precludes quantification of perfusion. While motion correction techniques have been proposed, they have been hampered by the challenge of accounting for dramatic contrast changes during the bolus and long execution times. In this work we investigate the use of a novel free-breathing multi-echo Dixon technique for quantitative myocardial perfusion. The Dixon fat images, unaffected by the dynamic contrast-enhancement, are used to efficiently estimate rigid-body respiratory motion and the computed transformations are applied to the corresponding diagnostic water images. This is followed by a second non-linear correction step using the Dixon water images to remove residual motion. The proposed Dixon motion correction technique was compared to the state-of-the-art technique (spatiotemporal based registration). We demonstrate that the proposed method performs comparably to the state-of-the-art but is significantly faster to execute. Furthermore, the proposed technique can be used to correct for the decay of signal due to T2* effects to improve quantification and additionally, yields fat-free diagnostic images.
format	article
author	Cian M. Scannell Teresa Correia Adriana D. M. Villa Torben Schneider Jack Lee Marcel Breeuwer Amedeo Chiribiri Markus Henningsson
author_facet	Cian M. Scannell Teresa Correia Adriana D. M. Villa Torben Schneider Jack Lee Marcel Breeuwer Amedeo Chiribiri Markus Henningsson
author_sort	Cian M. Scannell
title	Feasibility of free-breathing quantitative myocardial perfusion using multi-echo Dixon magnetic resonance imaging
title_short	Feasibility of free-breathing quantitative myocardial perfusion using multi-echo Dixon magnetic resonance imaging
title_full	Feasibility of free-breathing quantitative myocardial perfusion using multi-echo Dixon magnetic resonance imaging
title_fullStr	Feasibility of free-breathing quantitative myocardial perfusion using multi-echo Dixon magnetic resonance imaging
title_full_unstemmed	Feasibility of free-breathing quantitative myocardial perfusion using multi-echo Dixon magnetic resonance imaging
title_sort	feasibility of free-breathing quantitative myocardial perfusion using multi-echo dixon magnetic resonance imaging
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0c4aa488d2e746cba86f4b91a1eaf185
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Feasibility of free-breathing quantitative myocardial perfusion using multi-echo Dixon magnetic resonance imaging

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