A cortical attractor network with Martinotti cells driven by facilitating synapses.

The population of pyramidal cells significantly outnumbers the inhibitory interneurons in the neocortex, while at the same time the diversity of interneuron types is much more pronounced. One acknowledged key role of inhibition is to control the rate and patterning of pyramidal cell firing via negat...

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Autores principales:	Pradeep Krishnamurthy, Gilad Silberberg, Anders Lansner
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0c4af91e2e47488a881b86c39d23063b
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spelling	oai:doaj.org-article:0c4af91e2e47488a881b86c39d23063b2021-11-18T07:22:08ZA cortical attractor network with Martinotti cells driven by facilitating synapses.1932-620310.1371/journal.pone.0030752https://doaj.org/article/0c4af91e2e47488a881b86c39d23063b2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22523533/?tool=EBIhttps://doaj.org/toc/1932-6203The population of pyramidal cells significantly outnumbers the inhibitory interneurons in the neocortex, while at the same time the diversity of interneuron types is much more pronounced. One acknowledged key role of inhibition is to control the rate and patterning of pyramidal cell firing via negative feedback, but most likely the diversity of inhibitory pathways is matched by a corresponding diversity of functional roles. An important distinguishing feature of cortical interneurons is the variability of the short-term plasticity properties of synapses received from pyramidal cells. The Martinotti cell type has recently come under scrutiny due to the distinctly facilitating nature of the synapses they receive from pyramidal cells. This distinguishes these neurons from basket cells and other inhibitory interneurons typically targeted by depressing synapses. A key aspect of the work reported here has been to pinpoint the role of this variability. We first set out to reproduce quantitatively based on in vitro data the di-synaptic inhibitory microcircuit connecting two pyramidal cells via one or a few Martinotti cells. In a second step, we embedded this microcircuit in a previously developed attractor memory network model of neocortical layers 2/3. This model network demonstrated that basket cells with their characteristic depressing synapses are the first to discharge when the network enters an attractor state and that Martinotti cells respond with a delay, thereby shifting the excitation-inhibition balance and acting to terminate the attractor state. A parameter sensitivity analysis suggested that Martinotti cells might, in fact, play a dominant role in setting the attractor dwell time and thus cortical speed of processing, with cellular adaptation and synaptic depression having a less prominent role than previously thought.Pradeep KrishnamurthyGilad SilberbergAnders LansnerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e30752 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pradeep Krishnamurthy Gilad Silberberg Anders Lansner A cortical attractor network with Martinotti cells driven by facilitating synapses.
description	The population of pyramidal cells significantly outnumbers the inhibitory interneurons in the neocortex, while at the same time the diversity of interneuron types is much more pronounced. One acknowledged key role of inhibition is to control the rate and patterning of pyramidal cell firing via negative feedback, but most likely the diversity of inhibitory pathways is matched by a corresponding diversity of functional roles. An important distinguishing feature of cortical interneurons is the variability of the short-term plasticity properties of synapses received from pyramidal cells. The Martinotti cell type has recently come under scrutiny due to the distinctly facilitating nature of the synapses they receive from pyramidal cells. This distinguishes these neurons from basket cells and other inhibitory interneurons typically targeted by depressing synapses. A key aspect of the work reported here has been to pinpoint the role of this variability. We first set out to reproduce quantitatively based on in vitro data the di-synaptic inhibitory microcircuit connecting two pyramidal cells via one or a few Martinotti cells. In a second step, we embedded this microcircuit in a previously developed attractor memory network model of neocortical layers 2/3. This model network demonstrated that basket cells with their characteristic depressing synapses are the first to discharge when the network enters an attractor state and that Martinotti cells respond with a delay, thereby shifting the excitation-inhibition balance and acting to terminate the attractor state. A parameter sensitivity analysis suggested that Martinotti cells might, in fact, play a dominant role in setting the attractor dwell time and thus cortical speed of processing, with cellular adaptation and synaptic depression having a less prominent role than previously thought.
format	article
author	Pradeep Krishnamurthy Gilad Silberberg Anders Lansner
author_facet	Pradeep Krishnamurthy Gilad Silberberg Anders Lansner
author_sort	Pradeep Krishnamurthy
title	A cortical attractor network with Martinotti cells driven by facilitating synapses.
title_short	A cortical attractor network with Martinotti cells driven by facilitating synapses.
title_full	A cortical attractor network with Martinotti cells driven by facilitating synapses.
title_fullStr	A cortical attractor network with Martinotti cells driven by facilitating synapses.
title_full_unstemmed	A cortical attractor network with Martinotti cells driven by facilitating synapses.
title_sort	cortical attractor network with martinotti cells driven by facilitating synapses.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0c4af91e2e47488a881b86c39d23063b
work_keys_str_mv	AT pradeepkrishnamurthy acorticalattractornetworkwithmartinotticellsdrivenbyfacilitatingsynapses AT giladsilberberg acorticalattractornetworkwithmartinotticellsdrivenbyfacilitatingsynapses AT anderslansner acorticalattractornetworkwithmartinotticellsdrivenbyfacilitatingsynapses AT pradeepkrishnamurthy corticalattractornetworkwithmartinotticellsdrivenbyfacilitatingsynapses AT giladsilberberg corticalattractornetworkwithmartinotticellsdrivenbyfacilitatingsynapses AT anderslansner corticalattractornetworkwithmartinotticellsdrivenbyfacilitatingsynapses
_version_	1718423516455370752

A cortical attractor network with Martinotti cells driven by facilitating synapses.

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