Dependence receptors: new targets for cancer therapy

Abstract Dependence receptors are known to promote survival and positive signaling such as proliferation, migration, and differentiation when activated, but to actively trigger apoptosis when unbound to their ligand. Their abnormal regulation was shown to be an important feature of tumorigenesis, al...

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Autores principales:	Morgan Brisset, Mélodie Grandin, Agnès Bernet, Patrick Mehlen, Frédéric Hollande
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	apoptosis cancer hallmarks treatment resistance tumor progression Medicine (General) R5-920 Genetics QH426-470
Acceso en línea:	https://doaj.org/article/0c4f0d08899a4d80b0e26d0f7659852a
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spelling	oai:doaj.org-article:0c4f0d08899a4d80b0e26d0f7659852a2021-11-08T09:27:45ZDependence receptors: new targets for cancer therapy1757-46841757-467610.15252/emmm.202114495https://doaj.org/article/0c4f0d08899a4d80b0e26d0f7659852a2021-11-01T00:00:00Zhttps://doi.org/10.15252/emmm.202114495https://doaj.org/toc/1757-4676https://doaj.org/toc/1757-4684Abstract Dependence receptors are known to promote survival and positive signaling such as proliferation, migration, and differentiation when activated, but to actively trigger apoptosis when unbound to their ligand. Their abnormal regulation was shown to be an important feature of tumorigenesis, allowing cancer cells to escape apoptosis triggered by these receptors while promoting in parallel major aspects of tumorigenesis such as proliferation, angiogenesis, invasiveness, and chemoresistance. This involvement in multiple cancer hallmarks has raised interest in dependence receptors as targets for cancer therapy. Although additional studies remain necessary to fully understand the complexity of signaling pathways activated by these receptors and to target them efficiently, it is now clear that dependence receptors represent very exciting targets for future cancer treatment. This manuscript reviews current knowledge on the contribution of dependence receptors to cancer and highlights the potential for therapies that activate pro‐apoptotic functions of these proteins.Morgan BrissetMélodie GrandinAgnès BernetPatrick MehlenFrédéric HollandeWileyarticleapoptosiscancer hallmarkstreatment resistancetumor progressionMedicine (General)R5-920GeneticsQH426-470ENEMBO Molecular Medicine, Vol 13, Iss 11, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	apoptosis cancer hallmarks treatment resistance tumor progression Medicine (General) R5-920 Genetics QH426-470
spellingShingle	apoptosis cancer hallmarks treatment resistance tumor progression Medicine (General) R5-920 Genetics QH426-470 Morgan Brisset Mélodie Grandin Agnès Bernet Patrick Mehlen Frédéric Hollande Dependence receptors: new targets for cancer therapy
description	Abstract Dependence receptors are known to promote survival and positive signaling such as proliferation, migration, and differentiation when activated, but to actively trigger apoptosis when unbound to their ligand. Their abnormal regulation was shown to be an important feature of tumorigenesis, allowing cancer cells to escape apoptosis triggered by these receptors while promoting in parallel major aspects of tumorigenesis such as proliferation, angiogenesis, invasiveness, and chemoresistance. This involvement in multiple cancer hallmarks has raised interest in dependence receptors as targets for cancer therapy. Although additional studies remain necessary to fully understand the complexity of signaling pathways activated by these receptors and to target them efficiently, it is now clear that dependence receptors represent very exciting targets for future cancer treatment. This manuscript reviews current knowledge on the contribution of dependence receptors to cancer and highlights the potential for therapies that activate pro‐apoptotic functions of these proteins.
format	article
author	Morgan Brisset Mélodie Grandin Agnès Bernet Patrick Mehlen Frédéric Hollande
author_facet	Morgan Brisset Mélodie Grandin Agnès Bernet Patrick Mehlen Frédéric Hollande
author_sort	Morgan Brisset
title	Dependence receptors: new targets for cancer therapy
title_short	Dependence receptors: new targets for cancer therapy
title_full	Dependence receptors: new targets for cancer therapy
title_fullStr	Dependence receptors: new targets for cancer therapy
title_full_unstemmed	Dependence receptors: new targets for cancer therapy
title_sort	dependence receptors: new targets for cancer therapy
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/0c4f0d08899a4d80b0e26d0f7659852a
work_keys_str_mv	AT morganbrisset dependencereceptorsnewtargetsforcancertherapy AT melodiegrandin dependencereceptorsnewtargetsforcancertherapy AT agnesbernet dependencereceptorsnewtargetsforcancertherapy AT patrickmehlen dependencereceptorsnewtargetsforcancertherapy AT frederichollande dependencereceptorsnewtargetsforcancertherapy
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Dependence receptors: new targets for cancer therapy

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