Harmonization of quality metrics and power calculation in multi-omic studies

Harmonization of quality metrics and power calculation in multi-omic studies

Multi-omics studies are popular but lack rigorous criteria for experimental design. We define Figures of Merit across omics to comparatively describe their performance, and present new algorithms for sample size calculation in multi-omics experiments aiming either at feature selection or sample clas...

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Autores principales: Sonia Tarazona, Leandro Balzano-Nogueira, David Gómez-Cabrero, Andreas Schmidt, Axel Imhof, Thomas Hankemeier, Jesper Tegnér, Johan A. Westerhuis, Ana Conesa
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/0c51984a3d59449daf214ba0b39baeb7
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spelling oai:doaj.org-article:0c51984a3d59449daf214ba0b39baeb72021-12-02T17:39:52ZHarmonization of quality metrics and power calculation in multi-omic studies10.1038/s41467-020-16937-82041-1723https://doaj.org/article/0c51984a3d59449daf214ba0b39baeb72020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16937-8https://doaj.org/toc/2041-1723Multi-omics studies are popular but lack rigorous criteria for experimental design. We define Figures of Merit across omics to comparatively describe their performance, and present new algorithms for sample size calculation in multi-omics experiments aiming either at feature selection or sample classification.Sonia TarazonaLeandro Balzano-NogueiraDavid Gómez-CabreroAndreas SchmidtAxel ImhofThomas HankemeierJesper TegnérJohan A. WesterhuisAna ConesaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sonia Tarazona
Leandro Balzano-Nogueira
David Gómez-Cabrero
Andreas Schmidt
Axel Imhof
Thomas Hankemeier
Jesper Tegnér
Johan A. Westerhuis
Ana Conesa
Harmonization of quality metrics and power calculation in multi-omic studies
description Multi-omics studies are popular but lack rigorous criteria for experimental design. We define Figures of Merit across omics to comparatively describe their performance, and present new algorithms for sample size calculation in multi-omics experiments aiming either at feature selection or sample classification.
format article
author Sonia Tarazona
Leandro Balzano-Nogueira
David Gómez-Cabrero
Andreas Schmidt
Axel Imhof
Thomas Hankemeier
Jesper Tegnér
Johan A. Westerhuis
Ana Conesa
author_facet Sonia Tarazona
Leandro Balzano-Nogueira
David Gómez-Cabrero
Andreas Schmidt
Axel Imhof
Thomas Hankemeier
Jesper Tegnér
Johan A. Westerhuis
Ana Conesa
author_sort Sonia Tarazona
title Harmonization of quality metrics and power calculation in multi-omic studies
title_short Harmonization of quality metrics and power calculation in multi-omic studies
title_full Harmonization of quality metrics and power calculation in multi-omic studies
title_fullStr Harmonization of quality metrics and power calculation in multi-omic studies
title_full_unstemmed Harmonization of quality metrics and power calculation in multi-omic studies
title_sort harmonization of quality metrics and power calculation in multi-omic studies
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/0c51984a3d59449daf214ba0b39baeb7
work_keys_str_mv AT soniatarazona harmonizationofqualitymetricsandpowercalculationinmultiomicstudies
AT leandrobalzanonogueira harmonizationofqualitymetricsandpowercalculationinmultiomicstudies
AT davidgomezcabrero harmonizationofqualitymetricsandpowercalculationinmultiomicstudies
AT andreasschmidt harmonizationofqualitymetricsandpowercalculationinmultiomicstudies
AT axelimhof harmonizationofqualitymetricsandpowercalculationinmultiomicstudies
AT thomashankemeier harmonizationofqualitymetricsandpowercalculationinmultiomicstudies
AT jespertegner harmonizationofqualitymetricsandpowercalculationinmultiomicstudies
AT johanawesterhuis harmonizationofqualitymetricsandpowercalculationinmultiomicstudies
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