A trimethoprim derivative impedes antibiotic resistance evolution

The efficacy of the antibiotic trimethoprim, which inhibits bacterial dihydrofolate reductase (DHFR), is limited by the rapid emergence of resistant bacteria. Here, Manna et al. show that 4’-desmethyltrimethoprim inhibits DHFR and a common TMP-resistant variant, and impedes evolution of antibiotic r...

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Autores principales:	Madhu Sudan Manna, Yusuf Talha Tamer, Ilona Gaszek, Nicole Poulides, Ayesha Ahmed, Xiaoyu Wang, Furkan C. R. Toprak, DaNae R. Woodard, Andrew Y. Koh, Noelle S. Williams, Dominika Borek, Ali Rana Atilgan, John D. Hulleman, Canan Atilgan, Uttam Tambar, Erdal Toprak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c5515c73c4846e48b35aa04d428f118
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spelling	oai:doaj.org-article:0c5515c73c4846e48b35aa04d428f1182021-12-02T16:51:13ZA trimethoprim derivative impedes antibiotic resistance evolution10.1038/s41467-021-23191-z2041-1723https://doaj.org/article/0c5515c73c4846e48b35aa04d428f1182021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23191-zhttps://doaj.org/toc/2041-1723The efficacy of the antibiotic trimethoprim, which inhibits bacterial dihydrofolate reductase (DHFR), is limited by the rapid emergence of resistant bacteria. Here, Manna et al. show that 4’-desmethyltrimethoprim inhibits DHFR and a common TMP-resistant variant, and impedes evolution of antibiotic resistance by selecting against the emergence of this variant.Madhu Sudan MannaYusuf Talha TamerIlona GaszekNicole PoulidesAyesha AhmedXiaoyu WangFurkan C. R. ToprakDaNae R. WoodardAndrew Y. KohNoelle S. WilliamsDominika BorekAli Rana AtilganJohn D. HullemanCanan AtilganUttam TambarErdal ToprakNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Madhu Sudan Manna Yusuf Talha Tamer Ilona Gaszek Nicole Poulides Ayesha Ahmed Xiaoyu Wang Furkan C. R. Toprak DaNae R. Woodard Andrew Y. Koh Noelle S. Williams Dominika Borek Ali Rana Atilgan John D. Hulleman Canan Atilgan Uttam Tambar Erdal Toprak A trimethoprim derivative impedes antibiotic resistance evolution
description	The efficacy of the antibiotic trimethoprim, which inhibits bacterial dihydrofolate reductase (DHFR), is limited by the rapid emergence of resistant bacteria. Here, Manna et al. show that 4’-desmethyltrimethoprim inhibits DHFR and a common TMP-resistant variant, and impedes evolution of antibiotic resistance by selecting against the emergence of this variant.
format	article
author	Madhu Sudan Manna Yusuf Talha Tamer Ilona Gaszek Nicole Poulides Ayesha Ahmed Xiaoyu Wang Furkan C. R. Toprak DaNae R. Woodard Andrew Y. Koh Noelle S. Williams Dominika Borek Ali Rana Atilgan John D. Hulleman Canan Atilgan Uttam Tambar Erdal Toprak
author_facet	Madhu Sudan Manna Yusuf Talha Tamer Ilona Gaszek Nicole Poulides Ayesha Ahmed Xiaoyu Wang Furkan C. R. Toprak DaNae R. Woodard Andrew Y. Koh Noelle S. Williams Dominika Borek Ali Rana Atilgan John D. Hulleman Canan Atilgan Uttam Tambar Erdal Toprak
author_sort	Madhu Sudan Manna
title	A trimethoprim derivative impedes antibiotic resistance evolution
title_short	A trimethoprim derivative impedes antibiotic resistance evolution
title_full	A trimethoprim derivative impedes antibiotic resistance evolution
title_fullStr	A trimethoprim derivative impedes antibiotic resistance evolution
title_full_unstemmed	A trimethoprim derivative impedes antibiotic resistance evolution
title_sort	trimethoprim derivative impedes antibiotic resistance evolution
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0c5515c73c4846e48b35aa04d428f118
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A trimethoprim derivative impedes antibiotic resistance evolution

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