SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site

Allen et al. determine crystal structure of the N-terminus of SWI/SNF chromatin remodelling factor subunit BAF155. They identify an interconnected structure of MarR-like, BRCT and chromodomains, visualise the potential effect of cancer-associated missense mutations and suggest a binding site and tar...

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Autores principales:	Mark D. Allen, Stefan M. V. Freund, Mark Bycroft, Giovanna Zinzalla
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0c57c506282247f9b60c617c12226435
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spelling	oai:doaj.org-article:0c57c506282247f9b60c617c122264352021-12-02T14:49:42ZSWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site10.1038/s42003-021-02050-z2399-3642https://doaj.org/article/0c57c506282247f9b60c617c122264352021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02050-zhttps://doaj.org/toc/2399-3642Allen et al. determine crystal structure of the N-terminus of SWI/SNF chromatin remodelling factor subunit BAF155. They identify an interconnected structure of MarR-like, BRCT and chromodomains, visualise the potential effect of cancer-associated missense mutations and suggest a binding site and target for small molecule inhibitors.Mark D. AllenStefan M. V. FreundMark BycroftGiovanna ZinzallaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mark D. Allen Stefan M. V. Freund Mark Bycroft Giovanna Zinzalla SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site
description	Allen et al. determine crystal structure of the N-terminus of SWI/SNF chromatin remodelling factor subunit BAF155. They identify an interconnected structure of MarR-like, BRCT and chromodomains, visualise the potential effect of cancer-associated missense mutations and suggest a binding site and target for small molecule inhibitors.
format	article
author	Mark D. Allen Stefan M. V. Freund Mark Bycroft Giovanna Zinzalla
author_facet	Mark D. Allen Stefan M. V. Freund Mark Bycroft Giovanna Zinzalla
author_sort	Mark D. Allen
title	SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site
title_short	SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site
title_full	SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site
title_fullStr	SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site
title_full_unstemmed	SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site
title_sort	swi/snf subunit baf155 n-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0c57c506282247f9b60c617c12226435
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SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site

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