Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA

Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA

Translesion synthesis polymerase eta has a well characterized role in replicating past UV-induced DNA lesions and has recently been shown to act at difficult to replicate sequences. Here the authors show that its SUMOylation is required to recruit pol eta at the replication fork and to prevent under...

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Autores principales: Emmanuelle Despras, Méghane Sittewelle, Caroline Pouvelle, Noémie Delrieu, Agnès M Cordonnier, Patricia L Kannouche
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/0c5841f8ace040119aa12b6e3466aabe
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spelling oai:doaj.org-article:0c5841f8ace040119aa12b6e3466aabe2021-12-02T14:38:34ZRad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA10.1038/ncomms133262041-1723https://doaj.org/article/0c5841f8ace040119aa12b6e3466aabe2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13326https://doaj.org/toc/2041-1723Translesion synthesis polymerase eta has a well characterized role in replicating past UV-induced DNA lesions and has recently been shown to act at difficult to replicate sequences. Here the authors show that its SUMOylation is required to recruit pol eta at the replication fork and to prevent under-replicated DNA.Emmanuelle DesprasMéghane SittewelleCaroline PouvelleNoémie DelrieuAgnès M CordonnierPatricia L KannoucheNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Emmanuelle Despras
Méghane Sittewelle
Caroline Pouvelle
Noémie Delrieu
Agnès M Cordonnier
Patricia L Kannouche
Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA
description Translesion synthesis polymerase eta has a well characterized role in replicating past UV-induced DNA lesions and has recently been shown to act at difficult to replicate sequences. Here the authors show that its SUMOylation is required to recruit pol eta at the replication fork and to prevent under-replicated DNA.
format article
author Emmanuelle Despras
Méghane Sittewelle
Caroline Pouvelle
Noémie Delrieu
Agnès M Cordonnier
Patricia L Kannouche
author_facet Emmanuelle Despras
Méghane Sittewelle
Caroline Pouvelle
Noémie Delrieu
Agnès M Cordonnier
Patricia L Kannouche
author_sort Emmanuelle Despras
title Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA
title_short Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA
title_full Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA
title_fullStr Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA
title_full_unstemmed Rad18-dependent SUMOylation of human specialized DNA polymerase eta is required to prevent under-replicated DNA
title_sort rad18-dependent sumoylation of human specialized dna polymerase eta is required to prevent under-replicated dna
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/0c5841f8ace040119aa12b6e3466aabe
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