Going Forward and Back: The Complex Evolutionary History of the GPx

There is large diversity among glutathione peroxidase (GPx) enzymes regarding their function, structure, presence of the highly reactive selenocysteine (SeCys) residue, substrate usage, and reducing agent preference. Moreover, most vertebrate GPxs are very distinct from non-animal GPxs, and it is st...

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Autores principales:	Thomaz Stumpf Trenz, Camila Luiza Delaix, Andreia Carina Turchetto-Zolet, Marcel Zamocky, Fernanda Lazzarotto, Márcia Margis-Pinheiro
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	GPx peroxidase family evolution selenocysteine ROS Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0c586e2bcbdd42b28af80f9894c6aa82
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spelling	oai:doaj.org-article:0c586e2bcbdd42b28af80f9894c6aa822021-11-25T16:47:36ZGoing Forward and Back: The Complex Evolutionary History of the GPx10.3390/biology101111652079-7737https://doaj.org/article/0c586e2bcbdd42b28af80f9894c6aa822021-11-01T00:00:00Zhttps://www.mdpi.com/2079-7737/10/11/1165https://doaj.org/toc/2079-7737There is large diversity among glutathione peroxidase (GPx) enzymes regarding their function, structure, presence of the highly reactive selenocysteine (SeCys) residue, substrate usage, and reducing agent preference. Moreover, most vertebrate GPxs are very distinct from non-animal GPxs, and it is still unclear if they came from a common GPx ancestor. In this study, we aimed to unveil how GPx evolved throughout different phyla. Based on our phylogenetic trees and sequence analyses, we propose that all GPx encoding genes share a monomeric common ancestor and that the SeCys amino acid was incorporated early in the evolution of the metazoan kingdom. In addition, classical GPx and the cysteine-exclusive GPx07 have been present since non-bilaterian animals, but they seem to have been lost throughout evolution in different phyla. Therefore, the birth-and-death of GPx family members (like in other oxidoreductase families) seems to be an ongoing process, occurring independently across different kingdoms and phyla.Thomaz Stumpf TrenzCamila Luiza DelaixAndreia Carina Turchetto-ZoletMarcel ZamockyFernanda LazzarottoMárcia Margis-PinheiroMDPI AGarticleGPxperoxidase familyevolutionselenocysteineROSBiology (General)QH301-705.5ENBiology, Vol 10, Iss 1165, p 1165 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	GPx peroxidase family evolution selenocysteine ROS Biology (General) QH301-705.5
spellingShingle	GPx peroxidase family evolution selenocysteine ROS Biology (General) QH301-705.5 Thomaz Stumpf Trenz Camila Luiza Delaix Andreia Carina Turchetto-Zolet Marcel Zamocky Fernanda Lazzarotto Márcia Margis-Pinheiro Going Forward and Back: The Complex Evolutionary History of the GPx
description	There is large diversity among glutathione peroxidase (GPx) enzymes regarding their function, structure, presence of the highly reactive selenocysteine (SeCys) residue, substrate usage, and reducing agent preference. Moreover, most vertebrate GPxs are very distinct from non-animal GPxs, and it is still unclear if they came from a common GPx ancestor. In this study, we aimed to unveil how GPx evolved throughout different phyla. Based on our phylogenetic trees and sequence analyses, we propose that all GPx encoding genes share a monomeric common ancestor and that the SeCys amino acid was incorporated early in the evolution of the metazoan kingdom. In addition, classical GPx and the cysteine-exclusive GPx07 have been present since non-bilaterian animals, but they seem to have been lost throughout evolution in different phyla. Therefore, the birth-and-death of GPx family members (like in other oxidoreductase families) seems to be an ongoing process, occurring independently across different kingdoms and phyla.
format	article
author	Thomaz Stumpf Trenz Camila Luiza Delaix Andreia Carina Turchetto-Zolet Marcel Zamocky Fernanda Lazzarotto Márcia Margis-Pinheiro
author_facet	Thomaz Stumpf Trenz Camila Luiza Delaix Andreia Carina Turchetto-Zolet Marcel Zamocky Fernanda Lazzarotto Márcia Margis-Pinheiro
author_sort	Thomaz Stumpf Trenz
title	Going Forward and Back: The Complex Evolutionary History of the GPx
title_short	Going Forward and Back: The Complex Evolutionary History of the GPx
title_full	Going Forward and Back: The Complex Evolutionary History of the GPx
title_fullStr	Going Forward and Back: The Complex Evolutionary History of the GPx
title_full_unstemmed	Going Forward and Back: The Complex Evolutionary History of the GPx
title_sort	going forward and back: the complex evolutionary history of the gpx
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0c586e2bcbdd42b28af80f9894c6aa82
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Going Forward and Back: The Complex Evolutionary History of the GPx

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