Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing

The origin and progression of lung adenocarcinoma (LUAD) are still poorly understood. Here, the authors analyse LUAD composition and progression in patient samples using single-cell RNA-seq and multiplex imaging, revealing a potential transcriptional divergence from alveolar type 2 cells.

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Autores principales:	Zhoufeng Wang, Zhe Li, Kun Zhou, Chengdi Wang, Lili Jiang, Li Zhang, Ying Yang, Wenxin Luo, Wenliang Qiao, Gang Wang, Yinyun Ni, Shuiping Dai, Tingting Guo, Guiyi Ji, Minjie Xu, Yiying Liu, Zhixi Su, Guowei Che, Weimin Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c591a024d8f4eb4b166ebe45fe652aa
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spelling	oai:doaj.org-article:0c591a024d8f4eb4b166ebe45fe652aa2021-11-14T12:35:45ZDeciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing10.1038/s41467-021-26770-22041-1723https://doaj.org/article/0c591a024d8f4eb4b166ebe45fe652aa2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26770-2https://doaj.org/toc/2041-1723The origin and progression of lung adenocarcinoma (LUAD) are still poorly understood. Here, the authors analyse LUAD composition and progression in patient samples using single-cell RNA-seq and multiplex imaging, revealing a potential transcriptional divergence from alveolar type 2 cells.Zhoufeng WangZhe LiKun ZhouChengdi WangLili JiangLi ZhangYing YangWenxin LuoWenliang QiaoGang WangYinyun NiShuiping DaiTingting GuoGuiyi JiMinjie XuYiying LiuZhixi SuGuowei CheWeimin LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhoufeng Wang Zhe Li Kun Zhou Chengdi Wang Lili Jiang Li Zhang Ying Yang Wenxin Luo Wenliang Qiao Gang Wang Yinyun Ni Shuiping Dai Tingting Guo Guiyi Ji Minjie Xu Yiying Liu Zhixi Su Guowei Che Weimin Li Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing
description	The origin and progression of lung adenocarcinoma (LUAD) are still poorly understood. Here, the authors analyse LUAD composition and progression in patient samples using single-cell RNA-seq and multiplex imaging, revealing a potential transcriptional divergence from alveolar type 2 cells.
format	article
author	Zhoufeng Wang Zhe Li Kun Zhou Chengdi Wang Lili Jiang Li Zhang Ying Yang Wenxin Luo Wenliang Qiao Gang Wang Yinyun Ni Shuiping Dai Tingting Guo Guiyi Ji Minjie Xu Yiying Liu Zhixi Su Guowei Che Weimin Li
author_facet	Zhoufeng Wang Zhe Li Kun Zhou Chengdi Wang Lili Jiang Li Zhang Ying Yang Wenxin Luo Wenliang Qiao Gang Wang Yinyun Ni Shuiping Dai Tingting Guo Guiyi Ji Minjie Xu Yiying Liu Zhixi Su Guowei Che Weimin Li
author_sort	Zhoufeng Wang
title	Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing
title_short	Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing
title_full	Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing
title_fullStr	Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing
title_full_unstemmed	Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing
title_sort	deciphering cell lineage specification of human lung adenocarcinoma with single-cell rna sequencing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0c591a024d8f4eb4b166ebe45fe652aa
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Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing

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