Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer’s disease.

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Autores principales:	Julie Gonneaud, Alex T. Baria, Alexa Pichet Binette, Brian A. Gordon, Jasmeer P. Chhatwal, Carlos Cruchaga, Mathias Jucker, Johannes Levin, Stephen Salloway, Martin Farlow, Serge Gauthier, Tammie L. S. Benzinger, John C. Morris, Randall J. Bateman, John C. S. Breitner, Judes Poirier, Etienne Vachon-Presseau, Sylvia Villeneuve, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dominantly Inherited Alzheimer Network (DIAN) Study Group, Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c59d82b7ea64e8e9da8283d5d2f0d76
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spelling	oai:doaj.org-article:0c59d82b7ea64e8e9da8283d5d2f0d762021-12-02T19:12:25ZAccelerated functional brain aging in pre-clinical familial Alzheimer’s disease10.1038/s41467-021-25492-92041-1723https://doaj.org/article/0c59d82b7ea64e8e9da8283d5d2f0d762021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25492-9https://doaj.org/toc/2041-1723Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer’s disease.Julie GonneaudAlex T. BariaAlexa Pichet BinetteBrian A. GordonJasmeer P. ChhatwalCarlos CruchagaMathias JuckerJohannes LevinStephen SallowayMartin FarlowSerge GauthierTammie L. S. BenzingerJohn C. MorrisRandall J. BatemanJohn C. S. BreitnerJudes PoirierEtienne Vachon-PresseauSylvia VilleneuveAlzheimer’s Disease Neuroimaging Initiative (ADNI)Dominantly Inherited Alzheimer Network (DIAN) Study GroupPre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research GroupNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julie Gonneaud Alex T. Baria Alexa Pichet Binette Brian A. Gordon Jasmeer P. Chhatwal Carlos Cruchaga Mathias Jucker Johannes Levin Stephen Salloway Martin Farlow Serge Gauthier Tammie L. S. Benzinger John C. Morris Randall J. Bateman John C. S. Breitner Judes Poirier Etienne Vachon-Presseau Sylvia Villeneuve Alzheimer’s Disease Neuroimaging Initiative (ADNI) Dominantly Inherited Alzheimer Network (DIAN) Study Group Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
description	Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer’s disease.
format	article
author	Julie Gonneaud Alex T. Baria Alexa Pichet Binette Brian A. Gordon Jasmeer P. Chhatwal Carlos Cruchaga Mathias Jucker Johannes Levin Stephen Salloway Martin Farlow Serge Gauthier Tammie L. S. Benzinger John C. Morris Randall J. Bateman John C. S. Breitner Judes Poirier Etienne Vachon-Presseau Sylvia Villeneuve Alzheimer’s Disease Neuroimaging Initiative (ADNI) Dominantly Inherited Alzheimer Network (DIAN) Study Group Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group
author_facet	Julie Gonneaud Alex T. Baria Alexa Pichet Binette Brian A. Gordon Jasmeer P. Chhatwal Carlos Cruchaga Mathias Jucker Johannes Levin Stephen Salloway Martin Farlow Serge Gauthier Tammie L. S. Benzinger John C. Morris Randall J. Bateman John C. S. Breitner Judes Poirier Etienne Vachon-Presseau Sylvia Villeneuve Alzheimer’s Disease Neuroimaging Initiative (ADNI) Dominantly Inherited Alzheimer Network (DIAN) Study Group Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group
author_sort	Julie Gonneaud
title	Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
title_short	Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
title_full	Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
title_fullStr	Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
title_full_unstemmed	Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
title_sort	accelerated functional brain aging in pre-clinical familial alzheimer’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0c59d82b7ea64e8e9da8283d5d2f0d76
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Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

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