Antibiotic resistance in uropathogenic enterobacteria

Multidrug-resistant Enterobacteriaceae are a major public health threat worldwide. These germs are the most redoubtable because they are producers of beta-lactamases and possess other mechanisms of resistance to many antibiotics. The objective of this work is to identify isolated strains of Enteroba...

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Autores principales:	Hamamouchi Jamila, Qasmaoui Aicha, Halout Karima, Charof Réda, Ohmani Farida
Formato:	article
Lenguaje:	EN FR
Publicado:	EDP Sciences 2021
Materias:	urinary tract infection enterobacteriaceae antibiotic resistance surveillance Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/0c5a51e2fb7940c1ac84e5d8d52823f2
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spelling	oai:doaj.org-article:0c5a51e2fb7940c1ac84e5d8d52823f22021-11-12T11:44:08ZAntibiotic resistance in uropathogenic enterobacteria2267-124210.1051/e3sconf/202131901102https://doaj.org/article/0c5a51e2fb7940c1ac84e5d8d52823f22021-01-01T00:00:00Zhttps://www.e3s-conferences.org/articles/e3sconf/pdf/2021/95/e3sconf_vigisan_01102.pdfhttps://doaj.org/toc/2267-1242Multidrug-resistant Enterobacteriaceae are a major public health threat worldwide. These germs are the most redoubtable because they are producers of beta-lactamases and possess other mechanisms of resistance to many antibiotics. The objective of this work is to identify isolated strains of Enterobacteriaceae and to study their antibiotic resistance profiles, thus contributing to the surveillance of antibioresistance. This is a retrospective study over a period of three years (2018-2020) including urine samples taken in the region of Rabat-Salé-Zaire and examined at the laboratory of Epidemic Diseases in National Institute of Hygiene of Rabat. Enterobacteriaceae were the most frequent germs with a predominance of Escherichia coli (68%) followed by Klebsiella pneumoniae (23%). Extended-spectrum beta-lactamase-producing Enterobacteriaceae accounted for 10.5%. The highest resistance was observed with amoxicillin, followed by ticarcillin, cefalotin, trimethoprim/sulfamethoxazole, amoxicillin+clavulanic acid, nalidixic acid and finally ciprofloxacin and norfloxacin. The aminoglycosides and the 2nd and 3rd cephalosporins were the most active molecules. The sensitivity of imipenem and ertapenem was 100%. This study shows the worrying appearance of resistance to the usual antibiotics in uropathogenic enterobacteria. Rational prescription of antibiotics and monitoring of the evolution of bacterial resistance are necessary in each region.Hamamouchi JamilaQasmaoui AichaHalout KarimaCharof RédaOhmani FaridaEDP Sciencesarticleurinary tract infectionenterobacteriaceaeantibiotic resistancesurveillanceEnvironmental sciencesGE1-350ENFRE3S Web of Conferences, Vol 319, p 01102 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	urinary tract infection enterobacteriaceae antibiotic resistance surveillance Environmental sciences GE1-350
spellingShingle	urinary tract infection enterobacteriaceae antibiotic resistance surveillance Environmental sciences GE1-350 Hamamouchi Jamila Qasmaoui Aicha Halout Karima Charof Réda Ohmani Farida Antibiotic resistance in uropathogenic enterobacteria
description	Multidrug-resistant Enterobacteriaceae are a major public health threat worldwide. These germs are the most redoubtable because they are producers of beta-lactamases and possess other mechanisms of resistance to many antibiotics. The objective of this work is to identify isolated strains of Enterobacteriaceae and to study their antibiotic resistance profiles, thus contributing to the surveillance of antibioresistance. This is a retrospective study over a period of three years (2018-2020) including urine samples taken in the region of Rabat-Salé-Zaire and examined at the laboratory of Epidemic Diseases in National Institute of Hygiene of Rabat. Enterobacteriaceae were the most frequent germs with a predominance of Escherichia coli (68%) followed by Klebsiella pneumoniae (23%). Extended-spectrum beta-lactamase-producing Enterobacteriaceae accounted for 10.5%. The highest resistance was observed with amoxicillin, followed by ticarcillin, cefalotin, trimethoprim/sulfamethoxazole, amoxicillin+clavulanic acid, nalidixic acid and finally ciprofloxacin and norfloxacin. The aminoglycosides and the 2nd and 3rd cephalosporins were the most active molecules. The sensitivity of imipenem and ertapenem was 100%. This study shows the worrying appearance of resistance to the usual antibiotics in uropathogenic enterobacteria. Rational prescription of antibiotics and monitoring of the evolution of bacterial resistance are necessary in each region.
format	article
author	Hamamouchi Jamila Qasmaoui Aicha Halout Karima Charof Réda Ohmani Farida
author_facet	Hamamouchi Jamila Qasmaoui Aicha Halout Karima Charof Réda Ohmani Farida
author_sort	Hamamouchi Jamila
title	Antibiotic resistance in uropathogenic enterobacteria
title_short	Antibiotic resistance in uropathogenic enterobacteria
title_full	Antibiotic resistance in uropathogenic enterobacteria
title_fullStr	Antibiotic resistance in uropathogenic enterobacteria
title_full_unstemmed	Antibiotic resistance in uropathogenic enterobacteria
title_sort	antibiotic resistance in uropathogenic enterobacteria
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/0c5a51e2fb7940c1ac84e5d8d52823f2
work_keys_str_mv	AT hamamouchijamila antibioticresistanceinuropathogenicenterobacteria AT qasmaouiaicha antibioticresistanceinuropathogenicenterobacteria AT haloutkarima antibioticresistanceinuropathogenicenterobacteria AT charofreda antibioticresistanceinuropathogenicenterobacteria AT ohmanifarida antibioticresistanceinuropathogenicenterobacteria
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Antibiotic resistance in uropathogenic enterobacteria

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