Advanced Coats’ disease treated with intravitreal bevacizumab combined with laser vascular ablation

Advanced Coats’ disease treated with intravitreal bevacizumab combined with laser vascular ablation

Victor M Villegas,1 Aaron S Gold,1 Audina M Berrocal,2 Timothy G Murray11Ocular Oncology and Retina, Miami, FL, USA; 2Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USAPurpose: To evaluate the impact of intravitreal bevacizumab c...

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Autores principales: Villegas VM, Gold AS, Berrocal AM, Murray TG
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
Materias:
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/0c5cf4e3f2494456841ebf345e1f90cf
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spelling oai:doaj.org-article:0c5cf4e3f2494456841ebf345e1f90cf2021-12-02T04:56:58ZAdvanced Coats’ disease treated with intravitreal bevacizumab combined with laser vascular ablation1177-5483https://doaj.org/article/0c5cf4e3f2494456841ebf345e1f90cf2014-05-01T00:00:00Zhttp://www.dovepress.com/advanced-coatsrsquo-disease-treated-with-intravitreal-bevacizumab-comb-a16878https://doaj.org/toc/1177-5483 Victor M Villegas,1 Aaron S Gold,1 Audina M Berrocal,2 Timothy G Murray11Ocular Oncology and Retina, Miami, FL, USA; 2Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USAPurpose: To evaluate the impact of intravitreal bevacizumab combined with laser vascular ablation in the management of advanced Coats’ disease presenting with exudative retinal detachment.Methods: This was a retrospective review of 24 children that presented with exudative retinal detachments associated with advanced Coats’ disease. Mean patient age was 62 months (range 9–160 months). Presenting signs included retinal detachment in 24 children (100%), vascular telangiectasia in 24 children (100%), and retinal ischemia in 24 children (100%). Twenty of 24 children presented with elevated, vascular leakage in the fovea (83%). Two children presented with sub-retinal fibrosis associated with presumed long-standing retinal detachment without evidence of rhegmatogenous retinal detachment. Ten patients exhibited vascular alterations in the periphery of the second eye without clinical evidence of exudation. All 24 children were treated with a large-spot-size diode laser directly to areas of abnormal telangiectatic vasculature. All 24 children received intravitreal bevacizumab injection. Results: All 24 children had resolution of exudative retinal detachment, ablation of vascular telangiectasia, and anatomic improvement of the retina. No child exhibited progressive retinal detachment and no eye required enucleation. No cases of neovascular glaucoma were seen. Fellow eyes with peripheral vascular alterations showed no progression to exudative vasculopathy during the observation period. Intravitreal bevacizumab injection was not associated with endophthalmitis or systemically-observed complications.Conclusion: Repetitive intravitreal bevacizumab combined with laser vascular ablation may be utilized effectively for advanced Coats’ disease presenting with exudative retinal detachment.Keywords: Coats’ disease, bevacizumab, anti-VEGF, laser ablation, retinaVillegas VMGold ASBerrocal AMMurray TGDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 973-976 (2014)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Villegas VM
Gold AS
Berrocal AM
Murray TG
Advanced Coats’ disease treated with intravitreal bevacizumab combined with laser vascular ablation
description Victor M Villegas,1 Aaron S Gold,1 Audina M Berrocal,2 Timothy G Murray11Ocular Oncology and Retina, Miami, FL, USA; 2Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USAPurpose: To evaluate the impact of intravitreal bevacizumab combined with laser vascular ablation in the management of advanced Coats’ disease presenting with exudative retinal detachment.Methods: This was a retrospective review of 24 children that presented with exudative retinal detachments associated with advanced Coats’ disease. Mean patient age was 62 months (range 9–160 months). Presenting signs included retinal detachment in 24 children (100%), vascular telangiectasia in 24 children (100%), and retinal ischemia in 24 children (100%). Twenty of 24 children presented with elevated, vascular leakage in the fovea (83%). Two children presented with sub-retinal fibrosis associated with presumed long-standing retinal detachment without evidence of rhegmatogenous retinal detachment. Ten patients exhibited vascular alterations in the periphery of the second eye without clinical evidence of exudation. All 24 children were treated with a large-spot-size diode laser directly to areas of abnormal telangiectatic vasculature. All 24 children received intravitreal bevacizumab injection. Results: All 24 children had resolution of exudative retinal detachment, ablation of vascular telangiectasia, and anatomic improvement of the retina. No child exhibited progressive retinal detachment and no eye required enucleation. No cases of neovascular glaucoma were seen. Fellow eyes with peripheral vascular alterations showed no progression to exudative vasculopathy during the observation period. Intravitreal bevacizumab injection was not associated with endophthalmitis or systemically-observed complications.Conclusion: Repetitive intravitreal bevacizumab combined with laser vascular ablation may be utilized effectively for advanced Coats’ disease presenting with exudative retinal detachment.Keywords: Coats’ disease, bevacizumab, anti-VEGF, laser ablation, retina
format article
author Villegas VM
Gold AS
Berrocal AM
Murray TG
author_facet Villegas VM
Gold AS
Berrocal AM
Murray TG
author_sort Villegas VM
title Advanced Coats’ disease treated with intravitreal bevacizumab combined with laser vascular ablation
title_short Advanced Coats’ disease treated with intravitreal bevacizumab combined with laser vascular ablation
title_full Advanced Coats’ disease treated with intravitreal bevacizumab combined with laser vascular ablation
title_fullStr Advanced Coats’ disease treated with intravitreal bevacizumab combined with laser vascular ablation
title_full_unstemmed Advanced Coats’ disease treated with intravitreal bevacizumab combined with laser vascular ablation
title_sort advanced coats’ disease treated with intravitreal bevacizumab combined with laser vascular ablation
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/0c5cf4e3f2494456841ebf345e1f90cf
work_keys_str_mv AT villegasvm advancedcoatsrsquodiseasetreatedwithintravitrealbevacizumabcombinedwithlaservascularablation
AT goldas advancedcoatsrsquodiseasetreatedwithintravitrealbevacizumabcombinedwithlaservascularablation
AT berrocalam advancedcoatsrsquodiseasetreatedwithintravitrealbevacizumabcombinedwithlaservascularablation
AT murraytg advancedcoatsrsquodiseasetreatedwithintravitrealbevacizumabcombinedwithlaservascularablation
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