Compulsive Eating in a Rat Model of Binge Eating Disorder Under Conditioned Fear and Exploration of Neural Mechanisms With c-fos mRNA Expression

Compulsive eating is the most obstinate feature of binge eating disorder. In this study, we observed the compulsive eating in our stress-induced binge-like eating rat model using a conflicting test, where sucrose and an aversively conditioned stimulus were presented at the same time. In this conflic...

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Autores principales:	Zhi Fei Li, Sandrine Chometton, Geneviève Guèvremont, Elena Timofeeva, Igor Timofeev
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	binge eating disorder compulsive eating reward devaluation c-fos expression fear conditioning nucleus accumbens Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/0c5db70fcf354be59d2c287085186d64
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spelling	oai:doaj.org-article:0c5db70fcf354be59d2c287085186d642021-12-01T13:15:41ZCompulsive Eating in a Rat Model of Binge Eating Disorder Under Conditioned Fear and Exploration of Neural Mechanisms With c-fos mRNA Expression1662-453X10.3389/fnins.2021.777572https://doaj.org/article/0c5db70fcf354be59d2c287085186d642021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.777572/fullhttps://doaj.org/toc/1662-453XCompulsive eating is the most obstinate feature of binge eating disorder. In this study, we observed the compulsive eating in our stress-induced binge-like eating rat model using a conflicting test, where sucrose and an aversively conditioned stimulus were presented at the same time. In this conflicting situation, the binge-like eating prone rats (BEPs), compared to the binge-like eating resistant rats (BERs), showed persistent high sucrose intake and inhibited fear response, respectively, indicating a deficit in palatability devaluation and stronger anxiolytic response to sucrose in the BEPs. We further analyzed the neuronal activation with c-fos mRNA in situ hybridization. Surprisingly, the sucrose access under conditioned fear did not inhibit the activity of amygdala; instead, it activated the central amygdala. In the BEPs, sucrose reduced the response of the paraventricular hypothalamic nucleus (PVN), while enhancing activities in the lateral hypothalamic area (LHA) to the CS. The resistance to devaluating the palatable food in the BEPs could be a result of persistent Acb response to sucrose intake and attenuated recruitment of the medial prefrontal cortex (mPFC). We interpret this finding as that the reward system of the BEPs overcame the homeostasis system and the stress-responding system.Zhi Fei LiZhi Fei LiZhi Fei LiZhi Fei LiSandrine ChomettonGeneviève GuèvremontElena TimofeevaIgor TimofeevFrontiers Media S.A.articlebinge eating disordercompulsive eatingreward devaluationc-fos expressionfear conditioningnucleus accumbensNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	binge eating disorder compulsive eating reward devaluation c-fos expression fear conditioning nucleus accumbens Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	binge eating disorder compulsive eating reward devaluation c-fos expression fear conditioning nucleus accumbens Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Zhi Fei Li Zhi Fei Li Zhi Fei Li Zhi Fei Li Sandrine Chometton Geneviève Guèvremont Elena Timofeeva Igor Timofeev Compulsive Eating in a Rat Model of Binge Eating Disorder Under Conditioned Fear and Exploration of Neural Mechanisms With c-fos mRNA Expression
description	Compulsive eating is the most obstinate feature of binge eating disorder. In this study, we observed the compulsive eating in our stress-induced binge-like eating rat model using a conflicting test, where sucrose and an aversively conditioned stimulus were presented at the same time. In this conflicting situation, the binge-like eating prone rats (BEPs), compared to the binge-like eating resistant rats (BERs), showed persistent high sucrose intake and inhibited fear response, respectively, indicating a deficit in palatability devaluation and stronger anxiolytic response to sucrose in the BEPs. We further analyzed the neuronal activation with c-fos mRNA in situ hybridization. Surprisingly, the sucrose access under conditioned fear did not inhibit the activity of amygdala; instead, it activated the central amygdala. In the BEPs, sucrose reduced the response of the paraventricular hypothalamic nucleus (PVN), while enhancing activities in the lateral hypothalamic area (LHA) to the CS. The resistance to devaluating the palatable food in the BEPs could be a result of persistent Acb response to sucrose intake and attenuated recruitment of the medial prefrontal cortex (mPFC). We interpret this finding as that the reward system of the BEPs overcame the homeostasis system and the stress-responding system.
format	article
author	Zhi Fei Li Zhi Fei Li Zhi Fei Li Zhi Fei Li Sandrine Chometton Geneviève Guèvremont Elena Timofeeva Igor Timofeev
author_facet	Zhi Fei Li Zhi Fei Li Zhi Fei Li Zhi Fei Li Sandrine Chometton Geneviève Guèvremont Elena Timofeeva Igor Timofeev
author_sort	Zhi Fei Li
title	Compulsive Eating in a Rat Model of Binge Eating Disorder Under Conditioned Fear and Exploration of Neural Mechanisms With c-fos mRNA Expression
title_short	Compulsive Eating in a Rat Model of Binge Eating Disorder Under Conditioned Fear and Exploration of Neural Mechanisms With c-fos mRNA Expression
title_full	Compulsive Eating in a Rat Model of Binge Eating Disorder Under Conditioned Fear and Exploration of Neural Mechanisms With c-fos mRNA Expression
title_fullStr	Compulsive Eating in a Rat Model of Binge Eating Disorder Under Conditioned Fear and Exploration of Neural Mechanisms With c-fos mRNA Expression
title_full_unstemmed	Compulsive Eating in a Rat Model of Binge Eating Disorder Under Conditioned Fear and Exploration of Neural Mechanisms With c-fos mRNA Expression
title_sort	compulsive eating in a rat model of binge eating disorder under conditioned fear and exploration of neural mechanisms with c-fos mrna expression
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/0c5db70fcf354be59d2c287085186d64
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Compulsive Eating in a Rat Model of Binge Eating Disorder Under Conditioned Fear and Exploration of Neural Mechanisms With c-fos mRNA Expression

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