Modeling the time evolution of the nanoparticle-protein corona in a body fluid.

<h4>Background</h4>Nanoparticles in contact with biological fluids interact with proteins and other biomolecules, thus forming a dynamic corona whose composition varies over time due to continuous protein association and dissociation events. Eventually equilibrium is reached, at which po...

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Autores principales:	Daniele Dell'Orco, Martin Lundqvist, Cecilia Oslakovic, Tommy Cedervall, Sara Linse
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0c612dcf4527454e9ad4d8bc338fcaf6
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id	oai:doaj.org-article:0c612dcf4527454e9ad4d8bc338fcaf6
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spelling	oai:doaj.org-article:0c612dcf4527454e9ad4d8bc338fcaf62021-12-02T20:21:12ZModeling the time evolution of the nanoparticle-protein corona in a body fluid.1932-620310.1371/journal.pone.0010949https://doaj.org/article/0c612dcf4527454e9ad4d8bc338fcaf62010-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20532175/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Nanoparticles in contact with biological fluids interact with proteins and other biomolecules, thus forming a dynamic corona whose composition varies over time due to continuous protein association and dissociation events. Eventually equilibrium is reached, at which point the continued exchange will not affect the composition of the corona.<h4>Results</h4>We developed a simple and effective dynamic model of the nanoparticle protein corona in a body fluid, namely human plasma. The model predicts the time evolution and equilibrium composition of the corona based on affinities, stoichiometries and rate constants. An application to the interaction of human serum albumin, high density lipoprotein (HDL) and fibrinogen with 70 nm N-iso-propylacrylamide/N-tert-butylacrylamide copolymer nanoparticles is presented, including novel experimental data for HDL.<h4>Conclusions</h4>The simple model presented here can easily be modified to mimic the interaction of the nanoparticle protein corona with a novel biological fluid or compartment once new data will be available, thus opening novel applications in nanotoxicity and nanomedicine.Daniele Dell'OrcoMartin LundqvistCecilia OslakovicTommy CedervallSara LinsePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 6, p e10949 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniele Dell'Orco Martin Lundqvist Cecilia Oslakovic Tommy Cedervall Sara Linse Modeling the time evolution of the nanoparticle-protein corona in a body fluid.
description	<h4>Background</h4>Nanoparticles in contact with biological fluids interact with proteins and other biomolecules, thus forming a dynamic corona whose composition varies over time due to continuous protein association and dissociation events. Eventually equilibrium is reached, at which point the continued exchange will not affect the composition of the corona.<h4>Results</h4>We developed a simple and effective dynamic model of the nanoparticle protein corona in a body fluid, namely human plasma. The model predicts the time evolution and equilibrium composition of the corona based on affinities, stoichiometries and rate constants. An application to the interaction of human serum albumin, high density lipoprotein (HDL) and fibrinogen with 70 nm N-iso-propylacrylamide/N-tert-butylacrylamide copolymer nanoparticles is presented, including novel experimental data for HDL.<h4>Conclusions</h4>The simple model presented here can easily be modified to mimic the interaction of the nanoparticle protein corona with a novel biological fluid or compartment once new data will be available, thus opening novel applications in nanotoxicity and nanomedicine.
format	article
author	Daniele Dell'Orco Martin Lundqvist Cecilia Oslakovic Tommy Cedervall Sara Linse
author_facet	Daniele Dell'Orco Martin Lundqvist Cecilia Oslakovic Tommy Cedervall Sara Linse
author_sort	Daniele Dell'Orco
title	Modeling the time evolution of the nanoparticle-protein corona in a body fluid.
title_short	Modeling the time evolution of the nanoparticle-protein corona in a body fluid.
title_full	Modeling the time evolution of the nanoparticle-protein corona in a body fluid.
title_fullStr	Modeling the time evolution of the nanoparticle-protein corona in a body fluid.
title_full_unstemmed	Modeling the time evolution of the nanoparticle-protein corona in a body fluid.
title_sort	modeling the time evolution of the nanoparticle-protein corona in a body fluid.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/0c612dcf4527454e9ad4d8bc338fcaf6
work_keys_str_mv	AT danieledellorco modelingthetimeevolutionofthenanoparticleproteincoronainabodyfluid AT martinlundqvist modelingthetimeevolutionofthenanoparticleproteincoronainabodyfluid AT ceciliaoslakovic modelingthetimeevolutionofthenanoparticleproteincoronainabodyfluid AT tommycedervall modelingthetimeevolutionofthenanoparticleproteincoronainabodyfluid AT saralinse modelingthetimeevolutionofthenanoparticleproteincoronainabodyfluid
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Modeling the time evolution of the nanoparticle-protein corona in a body fluid.

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