Substrate-driven mapping of the degradome by comparison of sequence logos.

Sequence logos are frequently used to illustrate substrate preferences and specificity of proteases. Here, we employed the compiled substrates of the MEROPS database to introduce a novel metric for comparison of protease substrate preferences. The constructed similarity matrix of 62 proteases can be...

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Autores principales: Julian E Fuchs, Susanne von Grafenstein, Roland G Huber, Christian Kramer, Klaus R Liedl
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/0c61c0e7a9f04c15a3da1ed5cdcf1f7d
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