Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex

Bacterial DNA gyrase is the only type II DNA topoisomerase capable of introducing negative supercoils into DNA and is of interest as a drug target. Here the authors present the cryo-EM structure of the complete E. coli DNA gyrase bound to a 180 bp double-stranded DNA and the antibiotic gepotidacin,...

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Autores principales:	Arnaud Vanden Broeck, Christophe Lotz, Julio Ortiz, Valérie Lamour
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c622b0d66c74b9a92e8c037224a2547
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spelling	oai:doaj.org-article:0c622b0d66c74b9a92e8c037224a25472021-12-02T14:35:43ZCryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex10.1038/s41467-019-12914-y2041-1723https://doaj.org/article/0c622b0d66c74b9a92e8c037224a25472019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12914-yhttps://doaj.org/toc/2041-1723Bacterial DNA gyrase is the only type II DNA topoisomerase capable of introducing negative supercoils into DNA and is of interest as a drug target. Here the authors present the cryo-EM structure of the complete E. coli DNA gyrase bound to a 180 bp double-stranded DNA and the antibiotic gepotidacin, which reveals the connections between the functional domains and their spatial organization.Arnaud Vanden BroeckChristophe LotzJulio OrtizValérie LamourNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arnaud Vanden Broeck Christophe Lotz Julio Ortiz Valérie Lamour Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex
description	Bacterial DNA gyrase is the only type II DNA topoisomerase capable of introducing negative supercoils into DNA and is of interest as a drug target. Here the authors present the cryo-EM structure of the complete E. coli DNA gyrase bound to a 180 bp double-stranded DNA and the antibiotic gepotidacin, which reveals the connections between the functional domains and their spatial organization.
format	article
author	Arnaud Vanden Broeck Christophe Lotz Julio Ortiz Valérie Lamour
author_facet	Arnaud Vanden Broeck Christophe Lotz Julio Ortiz Valérie Lamour
author_sort	Arnaud Vanden Broeck
title	Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex
title_short	Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex
title_full	Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex
title_fullStr	Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex
title_full_unstemmed	Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex
title_sort	cryo-em structure of the complete e. coli dna gyrase nucleoprotein complex
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0c622b0d66c74b9a92e8c037224a2547
work_keys_str_mv	AT arnaudvandenbroeck cryoemstructureofthecompleteecolidnagyrasenucleoproteincomplex AT christophelotz cryoemstructureofthecompleteecolidnagyrasenucleoproteincomplex AT julioortiz cryoemstructureofthecompleteecolidnagyrasenucleoproteincomplex AT valerielamour cryoemstructureofthecompleteecolidnagyrasenucleoproteincomplex
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Cryo-EM structure of the complete E. coli DNA gyrase nucleoprotein complex

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