Low alanine aminotransferase as a risk factor for chronic obstructive pulmonary disease in males

Abstract Alanine aminotransferase (ALT) levels reflect skeletal muscle volume and general performance, which are associated with chronic obstructive pulmonary disease (COPD) development and prognosis. This study aimed to investigate ALT levels as a risk factor for COPD development. This 13-year popu...

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Autores principales:	Yong Jun Choi, Do Sun Kwon, Taehee Kim, Jae Hwa Cho, Hyung Jung Kim, Min Kwang Byun, Hye Jung Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0c66c043fc644276b3c86cdbe63a2545
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spelling	oai:doaj.org-article:0c66c043fc644276b3c86cdbe63a25452021-12-02T16:17:18ZLow alanine aminotransferase as a risk factor for chronic obstructive pulmonary disease in males10.1038/s41598-021-94385-02045-2322https://doaj.org/article/0c66c043fc644276b3c86cdbe63a25452021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94385-0https://doaj.org/toc/2045-2322Abstract Alanine aminotransferase (ALT) levels reflect skeletal muscle volume and general performance, which are associated with chronic obstructive pulmonary disease (COPD) development and prognosis. This study aimed to investigate ALT levels as a risk factor for COPD development. This 13-year population-based retrospective observational cohort study included 422,452 participants for analysis. We classified groups according to the baseline ALT levels (groups 1–5: ALT (IU/L) < 10; 10–19; 20–29; 30–39; and ≥ 40, respectively). The incidence of COPD was the highest in group 1, decreasing as the group number increased in males, but not in females. The Cox regression analysis in males revealed that a lower ALT level, as a continuous variable, was a significant risk factor for COPD development [univariable, hazard ratio (HR): 0.992, 95% confidence interval (CI): 0.991–0.994; multivariable, HR: 0.998, 95% CI: 0.996–0.999]. In addition, COPD was more likely to develop in the lower ALT level groups (groups 1–4; < 40 IU/L), than in the highest ALT level group (group 5; ≥ 40 IU/L) (univariable, HR: 1.341, 95% CI: 1.263–1.424; multivariable, HR: 1.097, 95% CI: 1.030–1.168). Our findings suggest that males with low ALT levels should be carefully monitored for COPD development.Yong Jun ChoiDo Sun KwonTaehee KimJae Hwa ChoHyung Jung KimMin Kwang ByunHye Jung ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yong Jun Choi Do Sun Kwon Taehee Kim Jae Hwa Cho Hyung Jung Kim Min Kwang Byun Hye Jung Park Low alanine aminotransferase as a risk factor for chronic obstructive pulmonary disease in males
description	Abstract Alanine aminotransferase (ALT) levels reflect skeletal muscle volume and general performance, which are associated with chronic obstructive pulmonary disease (COPD) development and prognosis. This study aimed to investigate ALT levels as a risk factor for COPD development. This 13-year population-based retrospective observational cohort study included 422,452 participants for analysis. We classified groups according to the baseline ALT levels (groups 1–5: ALT (IU/L) < 10; 10–19; 20–29; 30–39; and ≥ 40, respectively). The incidence of COPD was the highest in group 1, decreasing as the group number increased in males, but not in females. The Cox regression analysis in males revealed that a lower ALT level, as a continuous variable, was a significant risk factor for COPD development [univariable, hazard ratio (HR): 0.992, 95% confidence interval (CI): 0.991–0.994; multivariable, HR: 0.998, 95% CI: 0.996–0.999]. In addition, COPD was more likely to develop in the lower ALT level groups (groups 1–4; < 40 IU/L), than in the highest ALT level group (group 5; ≥ 40 IU/L) (univariable, HR: 1.341, 95% CI: 1.263–1.424; multivariable, HR: 1.097, 95% CI: 1.030–1.168). Our findings suggest that males with low ALT levels should be carefully monitored for COPD development.
format	article
author	Yong Jun Choi Do Sun Kwon Taehee Kim Jae Hwa Cho Hyung Jung Kim Min Kwang Byun Hye Jung Park
author_facet	Yong Jun Choi Do Sun Kwon Taehee Kim Jae Hwa Cho Hyung Jung Kim Min Kwang Byun Hye Jung Park
author_sort	Yong Jun Choi
title	Low alanine aminotransferase as a risk factor for chronic obstructive pulmonary disease in males
title_short	Low alanine aminotransferase as a risk factor for chronic obstructive pulmonary disease in males
title_full	Low alanine aminotransferase as a risk factor for chronic obstructive pulmonary disease in males
title_fullStr	Low alanine aminotransferase as a risk factor for chronic obstructive pulmonary disease in males
title_full_unstemmed	Low alanine aminotransferase as a risk factor for chronic obstructive pulmonary disease in males
title_sort	low alanine aminotransferase as a risk factor for chronic obstructive pulmonary disease in males
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0c66c043fc644276b3c86cdbe63a2545
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Low alanine aminotransferase as a risk factor for chronic obstructive pulmonary disease in males

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