Ghrelin Expression in Mast Cells of Infant Lung with Respiratory Distress Syndrome

This article sheds light on some features of ghrelin (GHR)- and tryptase (Try)-positive mast cells (MCs) distribution in human lung of preterm newborns with respiratory distress syndrome (RDS). GHR possessed anti-inflammatory activity and reliable therapeutic properties in some lung diseases. So far...

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Autores principales:	Ivanova K., Stefanov I., Ivanova I., Ananiev J., Gulubova M.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	ghrelin mast cells respiratory distress syndrome Medicine R
Acceso en línea:	https://doaj.org/article/0c6b90cc8fa04e9b86fdd814226781a2
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spelling	oai:doaj.org-article:0c6b90cc8fa04e9b86fdd814226781a22021-12-02T19:05:13ZGhrelin Expression in Mast Cells of Infant Lung with Respiratory Distress Syndrome0324-175010.2478/amb-2021-0006https://doaj.org/article/0c6b90cc8fa04e9b86fdd814226781a22021-04-01T00:00:00Zhttps://doi.org/10.2478/amb-2021-0006https://doaj.org/toc/0324-1750This article sheds light on some features of ghrelin (GHR)- and tryptase (Try)-positive mast cells (MCs) distribution in human lung of preterm newborns with respiratory distress syndrome (RDS). GHR possessed anti-inflammatory activity and reliable therapeutic properties in some lung diseases. So far, GHR expression has been defined predominantly in neuroendocrine cells of bronchial mucosa in fetal and infant lungs. Lung tissue from 8 dead newborns with RDS were investigated immunohistochemically with anti-GHR and anti-Try antibodies. The number of GHR+ and Try+ MCs was determined in three locations –bronchi, bronchiole and in alveolar septa. MCs were more numerous around main bronchi with diminishing numbers around bronchiole and in alveolar septa. The number of MCs in the latter was increased in newborns with pneumonia. The number of GHR+ MCs in alveolar septa was lower in newborns with RDS as compared to newborns with RDS combined with pneumonia (2.83 ± 1.13 vs 4.81 ± 2.6, p < 0.001). The amount of Try+ MCs along bronchial wall was significantly more than GHR+ MCs in RDS newborns (6.97 ± 4.53 vs 3.85 ± 4.30, p = 0.001). It could be supposed that pulmonary MCs increased in newborn lungs in inflammatory process. MCs in human lung contained GHR peptide that had immunomodulatory function and participated in hormone regulation of inflammation.Ivanova K.Stefanov I.Ivanova I.Ananiev J.Gulubova M.Sciendoarticleghrelinmast cellsrespiratory distress syndromeMedicineRENActa Medica Bulgarica, Vol 48, Iss 1, Pp 40-45 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ghrelin mast cells respiratory distress syndrome Medicine R
spellingShingle	ghrelin mast cells respiratory distress syndrome Medicine R Ivanova K. Stefanov I. Ivanova I. Ananiev J. Gulubova M. Ghrelin Expression in Mast Cells of Infant Lung with Respiratory Distress Syndrome
description	This article sheds light on some features of ghrelin (GHR)- and tryptase (Try)-positive mast cells (MCs) distribution in human lung of preterm newborns with respiratory distress syndrome (RDS). GHR possessed anti-inflammatory activity and reliable therapeutic properties in some lung diseases. So far, GHR expression has been defined predominantly in neuroendocrine cells of bronchial mucosa in fetal and infant lungs. Lung tissue from 8 dead newborns with RDS were investigated immunohistochemically with anti-GHR and anti-Try antibodies. The number of GHR+ and Try+ MCs was determined in three locations –bronchi, bronchiole and in alveolar septa. MCs were more numerous around main bronchi with diminishing numbers around bronchiole and in alveolar septa. The number of MCs in the latter was increased in newborns with pneumonia. The number of GHR+ MCs in alveolar septa was lower in newborns with RDS as compared to newborns with RDS combined with pneumonia (2.83 ± 1.13 vs 4.81 ± 2.6, p < 0.001). The amount of Try+ MCs along bronchial wall was significantly more than GHR+ MCs in RDS newborns (6.97 ± 4.53 vs 3.85 ± 4.30, p = 0.001). It could be supposed that pulmonary MCs increased in newborn lungs in inflammatory process. MCs in human lung contained GHR peptide that had immunomodulatory function and participated in hormone regulation of inflammation.
format	article
author	Ivanova K. Stefanov I. Ivanova I. Ananiev J. Gulubova M.
author_facet	Ivanova K. Stefanov I. Ivanova I. Ananiev J. Gulubova M.
author_sort	Ivanova K.
title	Ghrelin Expression in Mast Cells of Infant Lung with Respiratory Distress Syndrome
title_short	Ghrelin Expression in Mast Cells of Infant Lung with Respiratory Distress Syndrome
title_full	Ghrelin Expression in Mast Cells of Infant Lung with Respiratory Distress Syndrome
title_fullStr	Ghrelin Expression in Mast Cells of Infant Lung with Respiratory Distress Syndrome
title_full_unstemmed	Ghrelin Expression in Mast Cells of Infant Lung with Respiratory Distress Syndrome
title_sort	ghrelin expression in mast cells of infant lung with respiratory distress syndrome
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/0c6b90cc8fa04e9b86fdd814226781a2
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Ghrelin Expression in Mast Cells of Infant Lung with Respiratory Distress Syndrome

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