Titania Nanotube Architectures Synthesized on 3D-Printed Ti-6Al-4V Implant and Assessing Vancomycin Release Protocols

The aim of this study is to synthesize Titania nanotubes (TNTs) on the 3D-printed Ti-6Al-4V surface and investigate the loading of antibacterial vancomycin drug dose of 200 ppm for local drug treatment application for 24 h. The antibacterial drug release from synthesized nanotubes evaluated via the...

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Autores principales:	H-thaichnok Chunate, Jirapon Khamwannah, Abdul Azeez Abdu Aliyu, Saran Tantavisut, Chedtha Puncreobutr, Atchara Khamkongkaeo, Chiraporn Tongyam, Krittima Tumkhanon, Thanawat Phetrattanarangsi, Theerapat Chanamuangkon, Torlarp Sitthiwanit, Dechawut Decha-umphai, Pharanroj Pongjirawish, Boonrat Lohwongwatana
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	3D printing Ti-6Al-4V titania nanotubes vancomycin electrostatic interaction Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
Acceso en línea:	https://doaj.org/article/0c72fa2884584f98b8a2ff59ad753e90
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spelling	oai:doaj.org-article:0c72fa2884584f98b8a2ff59ad753e902021-11-11T18:07:37ZTitania Nanotube Architectures Synthesized on 3D-Printed Ti-6Al-4V Implant and Assessing Vancomycin Release Protocols10.3390/ma142165761996-1944https://doaj.org/article/0c72fa2884584f98b8a2ff59ad753e902021-11-01T00:00:00Zhttps://www.mdpi.com/1996-1944/14/21/6576https://doaj.org/toc/1996-1944The aim of this study is to synthesize Titania nanotubes (TNTs) on the 3D-printed Ti-6Al-4V surface and investigate the loading of antibacterial vancomycin drug dose of 200 ppm for local drug treatment application for 24 h. The antibacterial drug release from synthesized nanotubes evaluated via the chemical surface measurement and the linear fitting of Korsmeyer–Peppas model was also assessed. The TNTs were synthesized on the Ti-6Al-4V surface through the anodization process at different anodization time. The TNTs morphology was characterized using field emission scanning electron microscope (FESEM). The wettability and the chemical composition of the Ti-6Al-4V surface and the TNTs were assessed using the contact angle meter, Fourier transform infrared spectrophotometer (FTIR) and the X-ray photoelectron spectroscopy (XPS). The vancomycin of 200 ppm release behavior under controlled atmosphere was measured by the high-performance liquid chromatography (HPLC) and hence, the position for retention time at 2.5 min was ascertained. The FESEM analysis confirmed the formation of nanostructured TNTs with vertically oriented, closely packed, smooth and unperforated walls. The maximum cumulative vancomycin release of 34.7% (69.5 ppm) was recorded at 24 h. The wetting angle of both Ti-6Al-4V implant and the TNTs were found below 90 degrees. This confirmed their excellent wettability.H-thaichnok ChunateJirapon KhamwannahAbdul Azeez Abdu AliyuSaran TantavisutChedtha PuncreobutrAtchara KhamkongkaeoChiraporn TongyamKrittima TumkhanonThanawat PhetrattanarangsiTheerapat ChanamuangkonTorlarp SitthiwanitDechawut Decha-umphaiPharanroj PongjirawishBoonrat LohwongwatanaMDPI AGarticle3D printingTi-6Al-4Vtitania nanotubesvancomycinelectrostatic interactionTechnologyTElectrical engineering. Electronics. Nuclear engineeringTK1-9971Engineering (General). Civil engineering (General)TA1-2040MicroscopyQH201-278.5Descriptive and experimental mechanicsQC120-168.85ENMaterials, Vol 14, Iss 6576, p 6576 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	3D printing Ti-6Al-4V titania nanotubes vancomycin electrostatic interaction Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85
spellingShingle	3D printing Ti-6Al-4V titania nanotubes vancomycin electrostatic interaction Technology T Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 H-thaichnok Chunate Jirapon Khamwannah Abdul Azeez Abdu Aliyu Saran Tantavisut Chedtha Puncreobutr Atchara Khamkongkaeo Chiraporn Tongyam Krittima Tumkhanon Thanawat Phetrattanarangsi Theerapat Chanamuangkon Torlarp Sitthiwanit Dechawut Decha-umphai Pharanroj Pongjirawish Boonrat Lohwongwatana Titania Nanotube Architectures Synthesized on 3D-Printed Ti-6Al-4V Implant and Assessing Vancomycin Release Protocols
description	The aim of this study is to synthesize Titania nanotubes (TNTs) on the 3D-printed Ti-6Al-4V surface and investigate the loading of antibacterial vancomycin drug dose of 200 ppm for local drug treatment application for 24 h. The antibacterial drug release from synthesized nanotubes evaluated via the chemical surface measurement and the linear fitting of Korsmeyer–Peppas model was also assessed. The TNTs were synthesized on the Ti-6Al-4V surface through the anodization process at different anodization time. The TNTs morphology was characterized using field emission scanning electron microscope (FESEM). The wettability and the chemical composition of the Ti-6Al-4V surface and the TNTs were assessed using the contact angle meter, Fourier transform infrared spectrophotometer (FTIR) and the X-ray photoelectron spectroscopy (XPS). The vancomycin of 200 ppm release behavior under controlled atmosphere was measured by the high-performance liquid chromatography (HPLC) and hence, the position for retention time at 2.5 min was ascertained. The FESEM analysis confirmed the formation of nanostructured TNTs with vertically oriented, closely packed, smooth and unperforated walls. The maximum cumulative vancomycin release of 34.7% (69.5 ppm) was recorded at 24 h. The wetting angle of both Ti-6Al-4V implant and the TNTs were found below 90 degrees. This confirmed their excellent wettability.
format	article
author	H-thaichnok Chunate Jirapon Khamwannah Abdul Azeez Abdu Aliyu Saran Tantavisut Chedtha Puncreobutr Atchara Khamkongkaeo Chiraporn Tongyam Krittima Tumkhanon Thanawat Phetrattanarangsi Theerapat Chanamuangkon Torlarp Sitthiwanit Dechawut Decha-umphai Pharanroj Pongjirawish Boonrat Lohwongwatana
author_facet	H-thaichnok Chunate Jirapon Khamwannah Abdul Azeez Abdu Aliyu Saran Tantavisut Chedtha Puncreobutr Atchara Khamkongkaeo Chiraporn Tongyam Krittima Tumkhanon Thanawat Phetrattanarangsi Theerapat Chanamuangkon Torlarp Sitthiwanit Dechawut Decha-umphai Pharanroj Pongjirawish Boonrat Lohwongwatana
author_sort	H-thaichnok Chunate
title	Titania Nanotube Architectures Synthesized on 3D-Printed Ti-6Al-4V Implant and Assessing Vancomycin Release Protocols
title_short	Titania Nanotube Architectures Synthesized on 3D-Printed Ti-6Al-4V Implant and Assessing Vancomycin Release Protocols
title_full	Titania Nanotube Architectures Synthesized on 3D-Printed Ti-6Al-4V Implant and Assessing Vancomycin Release Protocols
title_fullStr	Titania Nanotube Architectures Synthesized on 3D-Printed Ti-6Al-4V Implant and Assessing Vancomycin Release Protocols
title_full_unstemmed	Titania Nanotube Architectures Synthesized on 3D-Printed Ti-6Al-4V Implant and Assessing Vancomycin Release Protocols
title_sort	titania nanotube architectures synthesized on 3d-printed ti-6al-4v implant and assessing vancomycin release protocols
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0c72fa2884584f98b8a2ff59ad753e90
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Titania Nanotube Architectures Synthesized on 3D-Printed Ti-6Al-4V Implant and Assessing Vancomycin Release Protocols

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