Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells

The transcriptional programs of nuclei in the muscle syncytium were assumed to be homogenous except at the neuromuscular and myotendinous junctions. Here, using single-nucleus transcriptomics, the authors reveal a previously unrecognized diversity and dynamics of myonuclear transcriptional programs.

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Autores principales:	Minchul Kim, Vedran Franke, Bettina Brandt, Elijah D. Lowenstein, Verena Schöwel, Simone Spuler, Altuna Akalin, Carmen Birchmeier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c73b2a2ed2f4892ba50a3fd0390c9f8
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spelling	oai:doaj.org-article:0c73b2a2ed2f4892ba50a3fd0390c9f82021-12-02T13:57:45ZSingle-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells10.1038/s41467-020-20064-92041-1723https://doaj.org/article/0c73b2a2ed2f4892ba50a3fd0390c9f82020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20064-9https://doaj.org/toc/2041-1723The transcriptional programs of nuclei in the muscle syncytium were assumed to be homogenous except at the neuromuscular and myotendinous junctions. Here, using single-nucleus transcriptomics, the authors reveal a previously unrecognized diversity and dynamics of myonuclear transcriptional programs.Minchul KimVedran FrankeBettina BrandtElijah D. LowensteinVerena SchöwelSimone SpulerAltuna AkalinCarmen BirchmeierNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Minchul Kim Vedran Franke Bettina Brandt Elijah D. Lowenstein Verena Schöwel Simone Spuler Altuna Akalin Carmen Birchmeier Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells
description	The transcriptional programs of nuclei in the muscle syncytium were assumed to be homogenous except at the neuromuscular and myotendinous junctions. Here, using single-nucleus transcriptomics, the authors reveal a previously unrecognized diversity and dynamics of myonuclear transcriptional programs.
format	article
author	Minchul Kim Vedran Franke Bettina Brandt Elijah D. Lowenstein Verena Schöwel Simone Spuler Altuna Akalin Carmen Birchmeier
author_facet	Minchul Kim Vedran Franke Bettina Brandt Elijah D. Lowenstein Verena Schöwel Simone Spuler Altuna Akalin Carmen Birchmeier
author_sort	Minchul Kim
title	Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells
title_short	Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells
title_full	Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells
title_fullStr	Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells
title_full_unstemmed	Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells
title_sort	single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0c73b2a2ed2f4892ba50a3fd0390c9f8
work_keys_str_mv	AT minchulkim singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells AT vedranfranke singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells AT bettinabrandt singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells AT elijahdlowenstein singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells AT verenaschowel singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells AT simonespuler singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells AT altunaakalin singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells AT carmenbirchmeier singlenucleustranscriptomicsrevealsfunctionalcompartmentalizationinsyncytialskeletalmusclecells
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Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells

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