New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects

Curcumin and resveratrol are bioactive natural compounds displaying anti-inflammatory, anti-oxidant and anti-cancer properties. In this study, we compared the cytotoxic effects of these molecules and the molecular mechanisms involved against Her-2/neu-positive breast and salivary cancer cell lines....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andrea Arena, Maria Anele Romeo, Rossella Benedetti, Laura Masuelli, Roberto Bei, Maria Saveria Gilardini Montani, Mara Cirone
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Her-2/neu cancers resveratrol curcumin ER stress autophagy PI3K/AKT/mTOR Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/0c73cea9daa048e6af05939c68194904
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0c73cea9daa048e6af05939c68194904
record_format	dspace
spelling	oai:doaj.org-article:0c73cea9daa048e6af05939c681949042021-11-25T18:39:04ZNew Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects10.3390/ph141110681424-8247https://doaj.org/article/0c73cea9daa048e6af05939c681949042021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1068https://doaj.org/toc/1424-8247Curcumin and resveratrol are bioactive natural compounds displaying anti-inflammatory, anti-oxidant and anti-cancer properties. In this study, we compared the cytotoxic effects of these molecules and the molecular mechanisms involved against Her-2/neu-positive breast and salivary cancer cell lines. We found that both curcumin and resveratrol were efficient in reducing cancer cell survival and that they differently affected autophagy, ROS and activation of the PI3K/AKT/mTOR pathway. Moreover, we found that resveratrol and curcumin in combination exerted a stronger cytotoxic effect in correlation with the induction of a stronger ER stress and the upregulation of pro-death UPR molecule CHOP. This effect also correlated with the induction of pro-survival autophagy by curcumin and its inhibition by resveratrol. In conclusion, this study unveils new molecular mechanisms underlying the anti-cancer effects of resveratrol, curcumin and their combination, which can help to design new therapeutic strategies based on the use of these polyphenols.Andrea ArenaMaria Anele RomeoRossella BenedettiLaura MasuelliRoberto BeiMaria Saveria Gilardini MontaniMara CironeMDPI AGarticleHer-2/neu cancersresveratrolcurcuminER stressautophagyPI3K/AKT/mTORMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1068, p 1068 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Her-2/neu cancers resveratrol curcumin ER stress autophagy PI3K/AKT/mTOR Medicine R Pharmacy and materia medica RS1-441
spellingShingle	Her-2/neu cancers resveratrol curcumin ER stress autophagy PI3K/AKT/mTOR Medicine R Pharmacy and materia medica RS1-441 Andrea Arena Maria Anele Romeo Rossella Benedetti Laura Masuelli Roberto Bei Maria Saveria Gilardini Montani Mara Cirone New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects
description	Curcumin and resveratrol are bioactive natural compounds displaying anti-inflammatory, anti-oxidant and anti-cancer properties. In this study, we compared the cytotoxic effects of these molecules and the molecular mechanisms involved against Her-2/neu-positive breast and salivary cancer cell lines. We found that both curcumin and resveratrol were efficient in reducing cancer cell survival and that they differently affected autophagy, ROS and activation of the PI3K/AKT/mTOR pathway. Moreover, we found that resveratrol and curcumin in combination exerted a stronger cytotoxic effect in correlation with the induction of a stronger ER stress and the upregulation of pro-death UPR molecule CHOP. This effect also correlated with the induction of pro-survival autophagy by curcumin and its inhibition by resveratrol. In conclusion, this study unveils new molecular mechanisms underlying the anti-cancer effects of resveratrol, curcumin and their combination, which can help to design new therapeutic strategies based on the use of these polyphenols.
format	article
author	Andrea Arena Maria Anele Romeo Rossella Benedetti Laura Masuelli Roberto Bei Maria Saveria Gilardini Montani Mara Cirone
author_facet	Andrea Arena Maria Anele Romeo Rossella Benedetti Laura Masuelli Roberto Bei Maria Saveria Gilardini Montani Mara Cirone
author_sort	Andrea Arena
title	New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects
title_short	New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects
title_full	New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects
title_fullStr	New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects
title_full_unstemmed	New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects
title_sort	new insights into curcumin- and resveratrol-mediated anti-cancer effects
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0c73cea9daa048e6af05939c68194904
work_keys_str_mv	AT andreaarena newinsightsintocurcuminandresveratrolmediatedanticancereffects AT mariaaneleromeo newinsightsintocurcuminandresveratrolmediatedanticancereffects AT rossellabenedetti newinsightsintocurcuminandresveratrolmediatedanticancereffects AT lauramasuelli newinsightsintocurcuminandresveratrolmediatedanticancereffects AT robertobei newinsightsintocurcuminandresveratrolmediatedanticancereffects AT mariasaveriagilardinimontani newinsightsintocurcuminandresveratrolmediatedanticancereffects AT maracirone newinsightsintocurcuminandresveratrolmediatedanticancereffects
_version_	1718410815283920896

New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects

Ejemplares similares