Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK

KRas is frequently mutated in multiple cancer types; identifying drugs to treat such cancers is a good therapeutic strategy. Here, the authors perform a synthetic lethal screen in mice and show that inhibiting Plk1 and ROCK results in the inhibition of tumour growth by increasing expression of the t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jieqiong Wang, Kewen Hu, Jiawei Guo, Feixiong Cheng, Jing Lv, Wenhao Jiang, Weiqiang Lu, Jinsong Liu, Xiufeng Pang, Mingyao Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c74c6b0573c4f9f816fe66db2394a14
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0c74c6b0573c4f9f816fe66db2394a14
record_format	dspace
spelling	oai:doaj.org-article:0c74c6b0573c4f9f816fe66db2394a142021-12-02T17:33:21ZSuppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK10.1038/ncomms113632041-1723https://doaj.org/article/0c74c6b0573c4f9f816fe66db2394a142016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11363https://doaj.org/toc/2041-1723KRas is frequently mutated in multiple cancer types; identifying drugs to treat such cancers is a good therapeutic strategy. Here, the authors perform a synthetic lethal screen in mice and show that inhibiting Plk1 and ROCK results in the inhibition of tumour growth by increasing expression of the tumour suppressor p21.Jieqiong WangKewen HuJiawei GuoFeixiong ChengJing LvWenhao JiangWeiqiang LuJinsong LiuXiufeng PangMingyao LiuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jieqiong Wang Kewen Hu Jiawei Guo Feixiong Cheng Jing Lv Wenhao Jiang Weiqiang Lu Jinsong Liu Xiufeng Pang Mingyao Liu Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK
description	KRas is frequently mutated in multiple cancer types; identifying drugs to treat such cancers is a good therapeutic strategy. Here, the authors perform a synthetic lethal screen in mice and show that inhibiting Plk1 and ROCK results in the inhibition of tumour growth by increasing expression of the tumour suppressor p21.
format	article
author	Jieqiong Wang Kewen Hu Jiawei Guo Feixiong Cheng Jing Lv Wenhao Jiang Weiqiang Lu Jinsong Liu Xiufeng Pang Mingyao Liu
author_facet	Jieqiong Wang Kewen Hu Jiawei Guo Feixiong Cheng Jing Lv Wenhao Jiang Weiqiang Lu Jinsong Liu Xiufeng Pang Mingyao Liu
author_sort	Jieqiong Wang
title	Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK
title_short	Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK
title_full	Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK
title_fullStr	Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK
title_full_unstemmed	Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK
title_sort	suppression of kras-mutant cancer through the combined inhibition of kras with plk1 and rock
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0c74c6b0573c4f9f816fe66db2394a14
work_keys_str_mv	AT jieqiongwang suppressionofkrasmutantcancerthroughthecombinedinhibitionofkraswithplk1androck AT kewenhu suppressionofkrasmutantcancerthroughthecombinedinhibitionofkraswithplk1androck AT jiaweiguo suppressionofkrasmutantcancerthroughthecombinedinhibitionofkraswithplk1androck AT feixiongcheng suppressionofkrasmutantcancerthroughthecombinedinhibitionofkraswithplk1androck AT jinglv suppressionofkrasmutantcancerthroughthecombinedinhibitionofkraswithplk1androck AT wenhaojiang suppressionofkrasmutantcancerthroughthecombinedinhibitionofkraswithplk1androck AT weiqianglu suppressionofkrasmutantcancerthroughthecombinedinhibitionofkraswithplk1androck AT jinsongliu suppressionofkrasmutantcancerthroughthecombinedinhibitionofkraswithplk1androck AT xiufengpang suppressionofkrasmutantcancerthroughthecombinedinhibitionofkraswithplk1androck AT mingyaoliu suppressionofkrasmutantcancerthroughthecombinedinhibitionofkraswithplk1androck
_version_	1718379922007785472

Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK

Ejemplares similares