Speech graphs provide a quantitative measure of thought disorder in psychosis.

<h4>Background</h4>Psychosis has various causes, including mania and schizophrenia. Since the differential diagnosis of psychosis is exclusively based on subjective assessments of oral interviews with patients, an objective quantification of the speech disturbances that characterize mani...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Natalia B Mota, Nivaldo A P Vasconcelos, Nathalia Lemos, Ana C Pieretti, Osame Kinouchi, Guillermo A Cecchi, Mauro Copelli, Sidarta Ribeiro
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0c7670fa8fca4879a6d1f2fc4eabf741
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0c7670fa8fca4879a6d1f2fc4eabf741
record_format	dspace
spelling	oai:doaj.org-article:0c7670fa8fca4879a6d1f2fc4eabf7412021-11-18T07:22:51ZSpeech graphs provide a quantitative measure of thought disorder in psychosis.1932-620310.1371/journal.pone.0034928https://doaj.org/article/0c7670fa8fca4879a6d1f2fc4eabf7412012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22506057/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Psychosis has various causes, including mania and schizophrenia. Since the differential diagnosis of psychosis is exclusively based on subjective assessments of oral interviews with patients, an objective quantification of the speech disturbances that characterize mania and schizophrenia is in order. In principle, such quantification could be achieved by the analysis of speech graphs. A graph represents a network with nodes connected by edges; in speech graphs, nodes correspond to words and edges correspond to semantic and grammatical relationships.<h4>Methodology/principal findings</h4>To quantify speech differences related to psychosis, interviews with schizophrenics, manics and normal subjects were recorded and represented as graphs. Manics scored significantly higher than schizophrenics in ten graph measures. Psychopathological symptoms such as logorrhea, poor speech, and flight of thoughts were grasped by the analysis even when verbosity differences were discounted. Binary classifiers based on speech graph measures sorted schizophrenics from manics with up to 93.8% of sensitivity and 93.7% of specificity. In contrast, sorting based on the scores of two standard psychiatric scales (BPRS and PANSS) reached only 62.5% of sensitivity and specificity.<h4>Conclusions/significance</h4>The results demonstrate that alterations of the thought process manifested in the speech of psychotic patients can be objectively measured using graph-theoretical tools, developed to capture specific features of the normal and dysfunctional flow of thought, such as divergence and recurrence. The quantitative analysis of speech graphs is not redundant with standard psychometric scales but rather complementary, as it yields a very accurate sorting of schizophrenics and manics. Overall, the results point to automated psychiatric diagnosis based not on what is said, but on how it is said.Natalia B MotaNivaldo A P VasconcelosNathalia LemosAna C PierettiOsame KinouchiGuillermo A CecchiMauro CopelliSidarta RibeiroPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e34928 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natalia B Mota Nivaldo A P Vasconcelos Nathalia Lemos Ana C Pieretti Osame Kinouchi Guillermo A Cecchi Mauro Copelli Sidarta Ribeiro Speech graphs provide a quantitative measure of thought disorder in psychosis.
description	<h4>Background</h4>Psychosis has various causes, including mania and schizophrenia. Since the differential diagnosis of psychosis is exclusively based on subjective assessments of oral interviews with patients, an objective quantification of the speech disturbances that characterize mania and schizophrenia is in order. In principle, such quantification could be achieved by the analysis of speech graphs. A graph represents a network with nodes connected by edges; in speech graphs, nodes correspond to words and edges correspond to semantic and grammatical relationships.<h4>Methodology/principal findings</h4>To quantify speech differences related to psychosis, interviews with schizophrenics, manics and normal subjects were recorded and represented as graphs. Manics scored significantly higher than schizophrenics in ten graph measures. Psychopathological symptoms such as logorrhea, poor speech, and flight of thoughts were grasped by the analysis even when verbosity differences were discounted. Binary classifiers based on speech graph measures sorted schizophrenics from manics with up to 93.8% of sensitivity and 93.7% of specificity. In contrast, sorting based on the scores of two standard psychiatric scales (BPRS and PANSS) reached only 62.5% of sensitivity and specificity.<h4>Conclusions/significance</h4>The results demonstrate that alterations of the thought process manifested in the speech of psychotic patients can be objectively measured using graph-theoretical tools, developed to capture specific features of the normal and dysfunctional flow of thought, such as divergence and recurrence. The quantitative analysis of speech graphs is not redundant with standard psychometric scales but rather complementary, as it yields a very accurate sorting of schizophrenics and manics. Overall, the results point to automated psychiatric diagnosis based not on what is said, but on how it is said.
format	article
author	Natalia B Mota Nivaldo A P Vasconcelos Nathalia Lemos Ana C Pieretti Osame Kinouchi Guillermo A Cecchi Mauro Copelli Sidarta Ribeiro
author_facet	Natalia B Mota Nivaldo A P Vasconcelos Nathalia Lemos Ana C Pieretti Osame Kinouchi Guillermo A Cecchi Mauro Copelli Sidarta Ribeiro
author_sort	Natalia B Mota
title	Speech graphs provide a quantitative measure of thought disorder in psychosis.
title_short	Speech graphs provide a quantitative measure of thought disorder in psychosis.
title_full	Speech graphs provide a quantitative measure of thought disorder in psychosis.
title_fullStr	Speech graphs provide a quantitative measure of thought disorder in psychosis.
title_full_unstemmed	Speech graphs provide a quantitative measure of thought disorder in psychosis.
title_sort	speech graphs provide a quantitative measure of thought disorder in psychosis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/0c7670fa8fca4879a6d1f2fc4eabf741
work_keys_str_mv	AT nataliabmota speechgraphsprovideaquantitativemeasureofthoughtdisorderinpsychosis AT nivaldoapvasconcelos speechgraphsprovideaquantitativemeasureofthoughtdisorderinpsychosis AT nathalialemos speechgraphsprovideaquantitativemeasureofthoughtdisorderinpsychosis AT anacpieretti speechgraphsprovideaquantitativemeasureofthoughtdisorderinpsychosis AT osamekinouchi speechgraphsprovideaquantitativemeasureofthoughtdisorderinpsychosis AT guillermoacecchi speechgraphsprovideaquantitativemeasureofthoughtdisorderinpsychosis AT maurocopelli speechgraphsprovideaquantitativemeasureofthoughtdisorderinpsychosis AT sidartaribeiro speechgraphsprovideaquantitativemeasureofthoughtdisorderinpsychosis
_version_	1718423516677668864

Speech graphs provide a quantitative measure of thought disorder in psychosis.

Ejemplares similares