A steric gate controls P/E hybrid-state formation of tRNA on the ribosome

The ribosome undergoes multiple large-scale structural rearrangements during protein elongation. Here the authors present an all-atom model of the ribosome to study the energetics of P/E hybrid-state formation, an early conformational rearrangement occurring during translocation.

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Detalles Bibliográficos
Autores principales: Mariana Levi, Kelsey Walak, Ailun Wang, Udayan Mohanty, Paul C. Whitford
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/0c77e490ee1d488495d31d990f104c0c
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Sumario:The ribosome undergoes multiple large-scale structural rearrangements during protein elongation. Here the authors present an all-atom model of the ribosome to study the energetics of P/E hybrid-state formation, an early conformational rearrangement occurring during translocation.