A steric gate controls P/E hybrid-state formation of tRNA on the ribosome

The ribosome undergoes multiple large-scale structural rearrangements during protein elongation. Here the authors present an all-atom model of the ribosome to study the energetics of P/E hybrid-state formation, an early conformational rearrangement occurring during translocation.

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Autores principales:	Mariana Levi, Kelsey Walak, Ailun Wang, Udayan Mohanty, Paul C. Whitford
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0c77e490ee1d488495d31d990f104c0c
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spelling	oai:doaj.org-article:0c77e490ee1d488495d31d990f104c0c2021-12-02T16:50:04ZA steric gate controls P/E hybrid-state formation of tRNA on the ribosome10.1038/s41467-020-19450-02041-1723https://doaj.org/article/0c77e490ee1d488495d31d990f104c0c2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19450-0https://doaj.org/toc/2041-1723The ribosome undergoes multiple large-scale structural rearrangements during protein elongation. Here the authors present an all-atom model of the ribosome to study the energetics of P/E hybrid-state formation, an early conformational rearrangement occurring during translocation.Mariana LeviKelsey WalakAilun WangUdayan MohantyPaul C. WhitfordNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mariana Levi Kelsey Walak Ailun Wang Udayan Mohanty Paul C. Whitford A steric gate controls P/E hybrid-state formation of tRNA on the ribosome
description	The ribosome undergoes multiple large-scale structural rearrangements during protein elongation. Here the authors present an all-atom model of the ribosome to study the energetics of P/E hybrid-state formation, an early conformational rearrangement occurring during translocation.
format	article
author	Mariana Levi Kelsey Walak Ailun Wang Udayan Mohanty Paul C. Whitford
author_facet	Mariana Levi Kelsey Walak Ailun Wang Udayan Mohanty Paul C. Whitford
author_sort	Mariana Levi
title	A steric gate controls P/E hybrid-state formation of tRNA on the ribosome
title_short	A steric gate controls P/E hybrid-state formation of tRNA on the ribosome
title_full	A steric gate controls P/E hybrid-state formation of tRNA on the ribosome
title_fullStr	A steric gate controls P/E hybrid-state formation of tRNA on the ribosome
title_full_unstemmed	A steric gate controls P/E hybrid-state formation of tRNA on the ribosome
title_sort	steric gate controls p/e hybrid-state formation of trna on the ribosome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0c77e490ee1d488495d31d990f104c0c
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_version_	1718383081088352256

A steric gate controls P/E hybrid-state formation of tRNA on the ribosome

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