Nicotine consumption during the prodromal phase of schizophrenia – a review of the literature
Athanasios Gogos,1,* Maria Skokou,2,* Eleni Ferentinou,1 Philippos Gourzis2 1School of Medicine, University of Patras, Rion, Patras, Greece; 2Department of Psychiatry, University Hospital of Patras, Rion, Patras, Greece*These authors contributed equally to this workCorrespondence: Philippos GourzisD...
Guardado en:
| Autores principales: | , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/0c795c00fde648c5999950ad22b45e9b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:0c795c00fde648c5999950ad22b45e9b |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:0c795c00fde648c5999950ad22b45e9b2021-12-02T09:14:35ZNicotine consumption during the prodromal phase of schizophrenia – a review of the literature1178-2021https://doaj.org/article/0c795c00fde648c5999950ad22b45e9b2019-10-01T00:00:00Zhttps://www.dovepress.com/nicotine-consumption-during-the-prodromal-phase-of-schizophrenia-a-rev-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Athanasios Gogos,1,* Maria Skokou,2,* Eleni Ferentinou,1 Philippos Gourzis2 1School of Medicine, University of Patras, Rion, Patras, Greece; 2Department of Psychiatry, University Hospital of Patras, Rion, Patras, Greece*These authors contributed equally to this workCorrespondence: Philippos GourzisDepartment of Psychiatry, General University Hospital of Patras, School of Medicine, University of Patras, University Campus, Rio 26504, GreeceTel +30 2610 990559Fax +30 261 099 4534Email pgourzis@upatras.grAbstract: Recent research has fueled a debate concerning the role of nicotine in the emergence of schizophrenia. The three main hypotheses are: (a) the self-medication effect, (b) the causal relationship hypothesis, or (c) the shared diathesis hypothesis. To explore this role, the study of nicotine consumption during the initial prodromal phase of schizophrenia offers important opportunities. In the present work, 10 relevant studies are reviewed, out of 727 retrieved citations, in order to address questions regarding the prevalence of smoking in the prodromal period, the time of smoking initiation, existing patterns of tobacco use in relation with the escalation of prodromal symptoms into first psychotic episode, and potential differences in symptomatology between smokers and nonsmokers. Even though there was considerable heterogeneity among studies, relevant findings are discussed. Prevalence of nicotine use during the prodromal period was reported to be 16.6–46%. Tobacco use was found to be taken up most often before or during the prodromal period of schizophrenia. Even though a protective role of smoking has been reported by one study, other studies report an increased risk for psychosis, with hazard ratios 2.77 (95% CI: 2.34–3.43) and 2.21 (95% CI: 1.11–4.42) for female and male heavy smokers (11–20 and >20 cigarettes/day), respectively. In a different study, the risk of onset was associated with the progressive use of cannabis and tobacco prior to onset, particularly with rapid escalation to the highest levels of use. Also, nicotine use in ultra high risk (UHR) for developing psychosis subjects is associated with elevated cognitive performance, namely better processing speed, visual learning, and spatial working memory. As a conclusion, it appears that evidence accumulates supporting a possible etiologic role of smoking, in the emergence of schizophrenia along with diverse effects on patients’ symptomatology, already demonstrable at the prodromal phase. Future research employing better-defined criteria should further explore the patterns of use and effects of nicotine during the schizophrenia prodrome.Keywords: tobacco, smoking, psychosis, ultra high risk, conversion, clinical high riskGogos ASkokou MFerentinou EGourzis PDove Medical Pressarticletobaccosmokingpsychosisultra high riskconversionclinical high riskNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2943-2958 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
tobacco smoking psychosis ultra high risk conversion clinical high risk Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
tobacco smoking psychosis ultra high risk conversion clinical high risk Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Gogos A Skokou M Ferentinou E Gourzis P Nicotine consumption during the prodromal phase of schizophrenia – a review of the literature |
| description |
Athanasios Gogos,1,* Maria Skokou,2,* Eleni Ferentinou,1 Philippos Gourzis2 1School of Medicine, University of Patras, Rion, Patras, Greece; 2Department of Psychiatry, University Hospital of Patras, Rion, Patras, Greece*These authors contributed equally to this workCorrespondence: Philippos GourzisDepartment of Psychiatry, General University Hospital of Patras, School of Medicine, University of Patras, University Campus, Rio 26504, GreeceTel +30 2610 990559Fax +30 261 099 4534Email pgourzis@upatras.grAbstract: Recent research has fueled a debate concerning the role of nicotine in the emergence of schizophrenia. The three main hypotheses are: (a) the self-medication effect, (b) the causal relationship hypothesis, or (c) the shared diathesis hypothesis. To explore this role, the study of nicotine consumption during the initial prodromal phase of schizophrenia offers important opportunities. In the present work, 10 relevant studies are reviewed, out of 727 retrieved citations, in order to address questions regarding the prevalence of smoking in the prodromal period, the time of smoking initiation, existing patterns of tobacco use in relation with the escalation of prodromal symptoms into first psychotic episode, and potential differences in symptomatology between smokers and nonsmokers. Even though there was considerable heterogeneity among studies, relevant findings are discussed. Prevalence of nicotine use during the prodromal period was reported to be 16.6–46%. Tobacco use was found to be taken up most often before or during the prodromal period of schizophrenia. Even though a protective role of smoking has been reported by one study, other studies report an increased risk for psychosis, with hazard ratios 2.77 (95% CI: 2.34–3.43) and 2.21 (95% CI: 1.11–4.42) for female and male heavy smokers (11–20 and >20 cigarettes/day), respectively. In a different study, the risk of onset was associated with the progressive use of cannabis and tobacco prior to onset, particularly with rapid escalation to the highest levels of use. Also, nicotine use in ultra high risk (UHR) for developing psychosis subjects is associated with elevated cognitive performance, namely better processing speed, visual learning, and spatial working memory. As a conclusion, it appears that evidence accumulates supporting a possible etiologic role of smoking, in the emergence of schizophrenia along with diverse effects on patients’ symptomatology, already demonstrable at the prodromal phase. Future research employing better-defined criteria should further explore the patterns of use and effects of nicotine during the schizophrenia prodrome.Keywords: tobacco, smoking, psychosis, ultra high risk, conversion, clinical high risk |
| format |
article |
| author |
Gogos A Skokou M Ferentinou E Gourzis P |
| author_facet |
Gogos A Skokou M Ferentinou E Gourzis P |
| author_sort |
Gogos A |
| title |
Nicotine consumption during the prodromal phase of schizophrenia – a review of the literature |
| title_short |
Nicotine consumption during the prodromal phase of schizophrenia – a review of the literature |
| title_full |
Nicotine consumption during the prodromal phase of schizophrenia – a review of the literature |
| title_fullStr |
Nicotine consumption during the prodromal phase of schizophrenia – a review of the literature |
| title_full_unstemmed |
Nicotine consumption during the prodromal phase of schizophrenia – a review of the literature |
| title_sort |
nicotine consumption during the prodromal phase of schizophrenia – a review of the literature |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/0c795c00fde648c5999950ad22b45e9b |
| work_keys_str_mv |
AT gogosa nicotineconsumptionduringtheprodromalphaseofschizophreniandashareviewoftheliterature AT skokoum nicotineconsumptionduringtheprodromalphaseofschizophreniandashareviewoftheliterature AT ferentinoue nicotineconsumptionduringtheprodromalphaseofschizophreniandashareviewoftheliterature AT gourzisp nicotineconsumptionduringtheprodromalphaseofschizophreniandashareviewoftheliterature |
| _version_ |
1718398165454946304 |