Serological Responses to Influenza Vaccination during Pregnancy

Pregnant women, newborns, and infants under six months old are at the highest risk of developing severe and even fatal influenza. This risk is compounded by the inability to vaccinate infants under six months, highlighting the importance of vertically transferred immunity. This review identifies nov...

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Autores principales:	Ana Vazquez-Pagan, Stacey Schultz-Cherry
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	influenza vaccine pregnancy placenta passive immunity maternal antibody interference early life immunity Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0c7b3ec9e22d471c8c1f72f212d8a234
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spelling	oai:doaj.org-article:0c7b3ec9e22d471c8c1f72f212d8a2342021-11-25T18:24:58ZSerological Responses to Influenza Vaccination during Pregnancy10.3390/microorganisms91123052076-2607https://doaj.org/article/0c7b3ec9e22d471c8c1f72f212d8a2342021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2305https://doaj.org/toc/2076-2607Pregnant women, newborns, and infants under six months old are at the highest risk of developing severe and even fatal influenza. This risk is compounded by the inability to vaccinate infants under six months, highlighting the importance of vertically transferred immunity. This review identifies novel insights that have emerged from recent studies using animal models of pregnancy and vaccination. We also discuss the knowledge obtained using existing clinical trials that have evaluated influenza-specific serological responses in pregnant women and how these responses may impact early life immunity. We delineate the mechanisms involved in transferring specific maternal antibodies and discuss the consequences for early life immunity. Most importantly, we highlight the need for continued research using pregnant animal models and the inclusion of pregnant women, a commonly neglected population, when evaluating novel vaccine platforms to better serve and treat communicable diseases.Ana Vazquez-PaganStacey Schultz-CherryMDPI AGarticleinfluenza vaccinepregnancyplacentapassive immunitymaternal antibody interferenceearly life immunityBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2305, p 2305 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	influenza vaccine pregnancy placenta passive immunity maternal antibody interference early life immunity Biology (General) QH301-705.5
spellingShingle	influenza vaccine pregnancy placenta passive immunity maternal antibody interference early life immunity Biology (General) QH301-705.5 Ana Vazquez-Pagan Stacey Schultz-Cherry Serological Responses to Influenza Vaccination during Pregnancy
description	Pregnant women, newborns, and infants under six months old are at the highest risk of developing severe and even fatal influenza. This risk is compounded by the inability to vaccinate infants under six months, highlighting the importance of vertically transferred immunity. This review identifies novel insights that have emerged from recent studies using animal models of pregnancy and vaccination. We also discuss the knowledge obtained using existing clinical trials that have evaluated influenza-specific serological responses in pregnant women and how these responses may impact early life immunity. We delineate the mechanisms involved in transferring specific maternal antibodies and discuss the consequences for early life immunity. Most importantly, we highlight the need for continued research using pregnant animal models and the inclusion of pregnant women, a commonly neglected population, when evaluating novel vaccine platforms to better serve and treat communicable diseases.
format	article
author	Ana Vazquez-Pagan Stacey Schultz-Cherry
author_facet	Ana Vazquez-Pagan Stacey Schultz-Cherry
author_sort	Ana Vazquez-Pagan
title	Serological Responses to Influenza Vaccination during Pregnancy
title_short	Serological Responses to Influenza Vaccination during Pregnancy
title_full	Serological Responses to Influenza Vaccination during Pregnancy
title_fullStr	Serological Responses to Influenza Vaccination during Pregnancy
title_full_unstemmed	Serological Responses to Influenza Vaccination during Pregnancy
title_sort	serological responses to influenza vaccination during pregnancy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0c7b3ec9e22d471c8c1f72f212d8a234
work_keys_str_mv	AT anavazquezpagan serologicalresponsestoinfluenzavaccinationduringpregnancy AT staceyschultzcherry serologicalresponsestoinfluenzavaccinationduringpregnancy
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Serological Responses to Influenza Vaccination during Pregnancy

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