Eye movement characteristics provide an objective measure of visual processing changes in patients with visual snow syndrome

Abstract Visual snow syndrome (VSS) is a poorly understood neurological disorder that features a range of disabling sensory changes. Visual processing changes revealed previously in VSS appear consistent with poor attentional control, specifically, with difficulty controlling environmentally driven...

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Autores principales:	Emma J. Solly, Meaghan Clough, Allison M. McKendrick, Paige Foletta, Owen B. White, Joanne Fielding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0c7c8756bebb485d9c8be66d3e4f5f74
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spelling	oai:doaj.org-article:0c7c8756bebb485d9c8be66d3e4f5f742021-12-02T15:38:11ZEye movement characteristics provide an objective measure of visual processing changes in patients with visual snow syndrome10.1038/s41598-021-88788-22045-2322https://doaj.org/article/0c7c8756bebb485d9c8be66d3e4f5f742021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88788-2https://doaj.org/toc/2045-2322Abstract Visual snow syndrome (VSS) is a poorly understood neurological disorder that features a range of disabling sensory changes. Visual processing changes revealed previously in VSS appear consistent with poor attentional control, specifically, with difficulty controlling environmentally driven shifts of attention. This study sought to confirm this proposal by determining whether these changes were similarly evident where attention is internally driven. Sixty seven VSS patients and 37 controls completed two saccade tasks: the endogenously cued saccade task and saccadic Simon task. The endogenously cued saccade task correctly (valid trial) or incorrectly (invalid trial) pre-cues a target location using a centrally presented arrow. VSS patients generated significantly shorter saccade latencies for valid trials (p = 0.03), resulting in a greater magnitude cue effect (p = 0.02), i.e. the difference in latency between valid and invalid trials. The saccadic Simon task presents a peripheral cue which may be spatially congruent or incongruent with the subsequent target location. Latencies on this task were comparable for VSS patients and controls, with a normal Simon effect, i.e. shorter latencies for saccades to targets spatially congruent with the preceding cue. On both tasks, VSS patients generated more erroneous saccades than controls towards non-target locations (Endogenously cued saccade task: p = 0.02, saccadic Simon task: p = 0.04). These results demonstrate that cued shifts of attention differentially affect saccade generation in VSS patients. We propose that these changes are not due to impairment of frontally-mediated inhibitory control, but to heightened saccade-related activity in visual regions. These results contribute to a VSS ocular motor signature that may provide clinical utility as well as an objective measure of dysfunction to facilitate future research.Emma J. SollyMeaghan CloughAllison M. McKendrickPaige FolettaOwen B. WhiteJoanne FieldingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emma J. Solly Meaghan Clough Allison M. McKendrick Paige Foletta Owen B. White Joanne Fielding Eye movement characteristics provide an objective measure of visual processing changes in patients with visual snow syndrome
description	Abstract Visual snow syndrome (VSS) is a poorly understood neurological disorder that features a range of disabling sensory changes. Visual processing changes revealed previously in VSS appear consistent with poor attentional control, specifically, with difficulty controlling environmentally driven shifts of attention. This study sought to confirm this proposal by determining whether these changes were similarly evident where attention is internally driven. Sixty seven VSS patients and 37 controls completed two saccade tasks: the endogenously cued saccade task and saccadic Simon task. The endogenously cued saccade task correctly (valid trial) or incorrectly (invalid trial) pre-cues a target location using a centrally presented arrow. VSS patients generated significantly shorter saccade latencies for valid trials (p = 0.03), resulting in a greater magnitude cue effect (p = 0.02), i.e. the difference in latency between valid and invalid trials. The saccadic Simon task presents a peripheral cue which may be spatially congruent or incongruent with the subsequent target location. Latencies on this task were comparable for VSS patients and controls, with a normal Simon effect, i.e. shorter latencies for saccades to targets spatially congruent with the preceding cue. On both tasks, VSS patients generated more erroneous saccades than controls towards non-target locations (Endogenously cued saccade task: p = 0.02, saccadic Simon task: p = 0.04). These results demonstrate that cued shifts of attention differentially affect saccade generation in VSS patients. We propose that these changes are not due to impairment of frontally-mediated inhibitory control, but to heightened saccade-related activity in visual regions. These results contribute to a VSS ocular motor signature that may provide clinical utility as well as an objective measure of dysfunction to facilitate future research.
format	article
author	Emma J. Solly Meaghan Clough Allison M. McKendrick Paige Foletta Owen B. White Joanne Fielding
author_facet	Emma J. Solly Meaghan Clough Allison M. McKendrick Paige Foletta Owen B. White Joanne Fielding
author_sort	Emma J. Solly
title	Eye movement characteristics provide an objective measure of visual processing changes in patients with visual snow syndrome
title_short	Eye movement characteristics provide an objective measure of visual processing changes in patients with visual snow syndrome
title_full	Eye movement characteristics provide an objective measure of visual processing changes in patients with visual snow syndrome
title_fullStr	Eye movement characteristics provide an objective measure of visual processing changes in patients with visual snow syndrome
title_full_unstemmed	Eye movement characteristics provide an objective measure of visual processing changes in patients with visual snow syndrome
title_sort	eye movement characteristics provide an objective measure of visual processing changes in patients with visual snow syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0c7c8756bebb485d9c8be66d3e4f5f74
work_keys_str_mv	AT emmajsolly eyemovementcharacteristicsprovideanobjectivemeasureofvisualprocessingchangesinpatientswithvisualsnowsyndrome AT meaghanclough eyemovementcharacteristicsprovideanobjectivemeasureofvisualprocessingchangesinpatientswithvisualsnowsyndrome AT allisonmmckendrick eyemovementcharacteristicsprovideanobjectivemeasureofvisualprocessingchangesinpatientswithvisualsnowsyndrome AT paigefoletta eyemovementcharacteristicsprovideanobjectivemeasureofvisualprocessingchangesinpatientswithvisualsnowsyndrome AT owenbwhite eyemovementcharacteristicsprovideanobjectivemeasureofvisualprocessingchangesinpatientswithvisualsnowsyndrome AT joannefielding eyemovementcharacteristicsprovideanobjectivemeasureofvisualprocessingchangesinpatientswithvisualsnowsyndrome
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Eye movement characteristics provide an objective measure of visual processing changes in patients with visual snow syndrome

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