Potency of commonly retailed antibiotics in pharmacies found in Adama, Oromia regional state, Ethiopia.

<h4>Introduction</h4>Antibiotics are commonly used for the treatment and prevention of bacterial infections. The potency of antibiotics can be affected by factors such as temperature, light, moisture, and storage conditions. Inappropriate storage and transportation of antibiotics may lea...

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Autores principales:	Demelash Demissie, Teshome Geremew, Adinew Zewdu Chernet, Musa Mohammed Ali
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0c7df6a219da40698f45ec0813e00df4
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spelling	oai:doaj.org-article:0c7df6a219da40698f45ec0813e00df42021-12-02T20:09:44ZPotency of commonly retailed antibiotics in pharmacies found in Adama, Oromia regional state, Ethiopia.1932-620310.1371/journal.pone.0253971https://doaj.org/article/0c7df6a219da40698f45ec0813e00df42021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253971https://doaj.org/toc/1932-6203<h4>Introduction</h4>Antibiotics are commonly used for the treatment and prevention of bacterial infections. The potency of antibiotics can be affected by factors such as temperature, light, moisture, and storage conditions. Inappropriate storage and transportation of antibiotics may lead to loss of potency earlier than the expiry date. The aim of this study was to determine the potency and associated factors of commonly retailed antibiotics.<h4>Method</h4>Institution-based cross-sectional study was conducted on commonly retailed antibiotics in pharmacies that are available in Adama, Ethiopia from March 2018 to June 2018. This study focused on commonly ordered antibiotics such as amoxicillin, azithromycin, ciprofloxacin, and ceftriaxone. Antibiotics to be tested were selected by using a simple random sampling technique. Socio-demographic and related data were collected using a semi-structured questionnaire. Antibiotic susceptibility testing was performed using the disc diffusion method as described in the Clinical Laboratory Standard Institute guideline.<h4>Results</h4>Mean inhibition zones of amoxicillin, ciprofloxacin, azithromycin, and ceftriaxone were 14.2 ± 4 mm, 30.9 ± 4.2 mm, 17.47 ± 3.83 mm, and 32.7±1.8 respectively. Out of 164 antibiotics tested, 61% passed the potency test. The potency of antibiotics varies across different countries in which 53.7% and 54.6 of antibiotics from India and Ethiopia passed the potency test. All ceftriaxone tested in this study passed the potency test. Factors such as air condition of pharmacy (X2 = 4.27; p = 0.039), source of all antibiotics (X2 = 5.41; p = 0.02), and source of amoxicillin (X2 = 4.73; p = 0.03) were significantly associated with potency of antibiotics.<h4>Conclusions</h4>About 40% of antibiotics tested in the current study did not pass the potency test; this warrants further investigation to identify the magnitude of the problem and its causes at a large scale.Demelash DemissieTeshome GeremewAdinew Zewdu ChernetMusa Mohammed AliPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0253971 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Demelash Demissie Teshome Geremew Adinew Zewdu Chernet Musa Mohammed Ali Potency of commonly retailed antibiotics in pharmacies found in Adama, Oromia regional state, Ethiopia.
description	<h4>Introduction</h4>Antibiotics are commonly used for the treatment and prevention of bacterial infections. The potency of antibiotics can be affected by factors such as temperature, light, moisture, and storage conditions. Inappropriate storage and transportation of antibiotics may lead to loss of potency earlier than the expiry date. The aim of this study was to determine the potency and associated factors of commonly retailed antibiotics.<h4>Method</h4>Institution-based cross-sectional study was conducted on commonly retailed antibiotics in pharmacies that are available in Adama, Ethiopia from March 2018 to June 2018. This study focused on commonly ordered antibiotics such as amoxicillin, azithromycin, ciprofloxacin, and ceftriaxone. Antibiotics to be tested were selected by using a simple random sampling technique. Socio-demographic and related data were collected using a semi-structured questionnaire. Antibiotic susceptibility testing was performed using the disc diffusion method as described in the Clinical Laboratory Standard Institute guideline.<h4>Results</h4>Mean inhibition zones of amoxicillin, ciprofloxacin, azithromycin, and ceftriaxone were 14.2 ± 4 mm, 30.9 ± 4.2 mm, 17.47 ± 3.83 mm, and 32.7±1.8 respectively. Out of 164 antibiotics tested, 61% passed the potency test. The potency of antibiotics varies across different countries in which 53.7% and 54.6 of antibiotics from India and Ethiopia passed the potency test. All ceftriaxone tested in this study passed the potency test. Factors such as air condition of pharmacy (X2 = 4.27; p = 0.039), source of all antibiotics (X2 = 5.41; p = 0.02), and source of amoxicillin (X2 = 4.73; p = 0.03) were significantly associated with potency of antibiotics.<h4>Conclusions</h4>About 40% of antibiotics tested in the current study did not pass the potency test; this warrants further investigation to identify the magnitude of the problem and its causes at a large scale.
format	article
author	Demelash Demissie Teshome Geremew Adinew Zewdu Chernet Musa Mohammed Ali
author_facet	Demelash Demissie Teshome Geremew Adinew Zewdu Chernet Musa Mohammed Ali
author_sort	Demelash Demissie
title	Potency of commonly retailed antibiotics in pharmacies found in Adama, Oromia regional state, Ethiopia.
title_short	Potency of commonly retailed antibiotics in pharmacies found in Adama, Oromia regional state, Ethiopia.
title_full	Potency of commonly retailed antibiotics in pharmacies found in Adama, Oromia regional state, Ethiopia.
title_fullStr	Potency of commonly retailed antibiotics in pharmacies found in Adama, Oromia regional state, Ethiopia.
title_full_unstemmed	Potency of commonly retailed antibiotics in pharmacies found in Adama, Oromia regional state, Ethiopia.
title_sort	potency of commonly retailed antibiotics in pharmacies found in adama, oromia regional state, ethiopia.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0c7df6a219da40698f45ec0813e00df4
work_keys_str_mv	AT demelashdemissie potencyofcommonlyretailedantibioticsinpharmaciesfoundinadamaoromiaregionalstateethiopia AT teshomegeremew potencyofcommonlyretailedantibioticsinpharmaciesfoundinadamaoromiaregionalstateethiopia AT adinewzewduchernet potencyofcommonlyretailedantibioticsinpharmaciesfoundinadamaoromiaregionalstateethiopia AT musamohammedali potencyofcommonlyretailedantibioticsinpharmaciesfoundinadamaoromiaregionalstateethiopia
_version_	1718375044982243328

Potency of commonly retailed antibiotics in pharmacies found in Adama, Oromia regional state, Ethiopia.

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