DNA vaccination protects mice against Zika virus-induced damage to the testes
Zika virus (ZIKV) can persist in human semen and sperm, which can result in sexual transmission. Here, Griffinet al. show that a DNA vaccine, expressing ZIKV pre-membrane and envelope proteins, protects mice from infection-associated damage to testes and sperm, and prevents viral persistence in test...
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Nature Portfolio
2017
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oai:doaj.org-article:0c82ce7b193e4897a52f784c15fa050c2021-12-02T14:40:49ZDNA vaccination protects mice against Zika virus-induced damage to the testes10.1038/ncomms157432041-1723https://doaj.org/article/0c82ce7b193e4897a52f784c15fa050c2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15743https://doaj.org/toc/2041-1723Zika virus (ZIKV) can persist in human semen and sperm, which can result in sexual transmission. Here, Griffinet al. show that a DNA vaccine, expressing ZIKV pre-membrane and envelope proteins, protects mice from infection-associated damage to testes and sperm, and prevents viral persistence in testes.Bryan D. GriffinKar MuthumaniBryce M. WarnerAnna MajerMable HaganJonathan AudetDerek R. SteinCharlene RanadheeraTrina RacineMarc-Antoine De La VegaJocelyne PiretStephanie KucasKaylie N. TranKathy L. FrostChristine De GraffGeoff SouleLeanne ScharikowJennifer ScottGordon McTavishValerie SmidYoung K. ParkJoel N. MaslowNiranjan Y. SardesaiJ. Joseph KimXiao-jian YaoAlexander BelloRobbin LindsayGuy BoivinStephanie A. BoothDarwyn KobasaCarissa Embury-HyattDavid SafronetzDavid B. WeinerGary P. KobingerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Bryan D. Griffin Kar Muthumani Bryce M. Warner Anna Majer Mable Hagan Jonathan Audet Derek R. Stein Charlene Ranadheera Trina Racine Marc-Antoine De La Vega Jocelyne Piret Stephanie Kucas Kaylie N. Tran Kathy L. Frost Christine De Graff Geoff Soule Leanne Scharikow Jennifer Scott Gordon McTavish Valerie Smid Young K. Park Joel N. Maslow Niranjan Y. Sardesai J. Joseph Kim Xiao-jian Yao Alexander Bello Robbin Lindsay Guy Boivin Stephanie A. Booth Darwyn Kobasa Carissa Embury-Hyatt David Safronetz David B. Weiner Gary P. Kobinger DNA vaccination protects mice against Zika virus-induced damage to the testes |
| description |
Zika virus (ZIKV) can persist in human semen and sperm, which can result in sexual transmission. Here, Griffinet al. show that a DNA vaccine, expressing ZIKV pre-membrane and envelope proteins, protects mice from infection-associated damage to testes and sperm, and prevents viral persistence in testes. |
| format |
article |
| author |
Bryan D. Griffin Kar Muthumani Bryce M. Warner Anna Majer Mable Hagan Jonathan Audet Derek R. Stein Charlene Ranadheera Trina Racine Marc-Antoine De La Vega Jocelyne Piret Stephanie Kucas Kaylie N. Tran Kathy L. Frost Christine De Graff Geoff Soule Leanne Scharikow Jennifer Scott Gordon McTavish Valerie Smid Young K. Park Joel N. Maslow Niranjan Y. Sardesai J. Joseph Kim Xiao-jian Yao Alexander Bello Robbin Lindsay Guy Boivin Stephanie A. Booth Darwyn Kobasa Carissa Embury-Hyatt David Safronetz David B. Weiner Gary P. Kobinger |
| author_facet |
Bryan D. Griffin Kar Muthumani Bryce M. Warner Anna Majer Mable Hagan Jonathan Audet Derek R. Stein Charlene Ranadheera Trina Racine Marc-Antoine De La Vega Jocelyne Piret Stephanie Kucas Kaylie N. Tran Kathy L. Frost Christine De Graff Geoff Soule Leanne Scharikow Jennifer Scott Gordon McTavish Valerie Smid Young K. Park Joel N. Maslow Niranjan Y. Sardesai J. Joseph Kim Xiao-jian Yao Alexander Bello Robbin Lindsay Guy Boivin Stephanie A. Booth Darwyn Kobasa Carissa Embury-Hyatt David Safronetz David B. Weiner Gary P. Kobinger |
| author_sort |
Bryan D. Griffin |
| title |
DNA vaccination protects mice against Zika virus-induced damage to the testes |
| title_short |
DNA vaccination protects mice against Zika virus-induced damage to the testes |
| title_full |
DNA vaccination protects mice against Zika virus-induced damage to the testes |
| title_fullStr |
DNA vaccination protects mice against Zika virus-induced damage to the testes |
| title_full_unstemmed |
DNA vaccination protects mice against Zika virus-induced damage to the testes |
| title_sort |
dna vaccination protects mice against zika virus-induced damage to the testes |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/0c82ce7b193e4897a52f784c15fa050c |
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