Factors affecting treatment adherence to atomoxetine in ADHD: a systematic review

Tamás Treuer,1 Luis Méndez,2 William Montgomery,3 Shenghu Wu4 1Neuroscience Research, Eli Lilly and Company, Budapest, Hungary; 2Eli Lilly de Mexico, Mexico City, Mexico; 3Global Patient Outcomes and Real World Evidence, Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia;...

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Autores principales:	Treuer T, Méndez L, Montgomery W, Wu S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	treatment discontinuation adherence compliance ADHD medication relapse Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0c83fb1ec3ff4d678fd633e08091cc78
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spelling	oai:doaj.org-article:0c83fb1ec3ff4d678fd633e08091cc782021-12-02T05:15:16ZFactors affecting treatment adherence to atomoxetine in ADHD: a systematic review1178-2021https://doaj.org/article/0c83fb1ec3ff4d678fd633e08091cc782016-05-01T00:00:00Zhttps://www.dovepress.com/factors-affecting-treatment-adherence-to-atomoxetine-in-adhd-a-systema-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Tamás Treuer,1 Luis Méndez,2 William Montgomery,3 Shenghu Wu4 1Neuroscience Research, Eli Lilly and Company, Budapest, Hungary; 2Eli Lilly de Mexico, Mexico City, Mexico; 3Global Patient Outcomes and Real World Evidence, Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 4Neuroscience Research, Eli Lilly Asia, Inc, Shanghai, People’s Republic of China Abstract: The purpose of this paper was to systematically review the literature related to research about the factors affecting treatment adherence and discontinuation of atomoxetine in pediatric, adolescent, and adult patients with attention-deficit/hyperactivity disorder (ADHD). Medline was systematically searched using the following prespecified terms: “ADHD”, “Adherence”, “Compliance”, “Discontinuation”, and “Atomoxetine”. We identified 31 articles that met all inclusion and exclusion criteria. The findings from this review indicate that persistence and adherence to atomoxetine treatment were generally high. Factors found to influence adherence and nonadherence to atomoxetine treatment in ADHD in this review include age, sex, the definition of response used, length of treatment, initial dose of treatment, comorbid conditions, and reimbursement. Tolerability was cited as an important reason for treatment discontinuation. More research is needed to understand those factors that can help to identify patients at risk for poor adherence and interventions that could improve treatment adherence early in the stage of this illness to secure a better long-term prognosis. Keywords: atomoxetine, treatment discontinuation, adherence, compliance, ADHD medication, relapseTreuer TMéndez LMontgomery WWu SDove Medical Pressarticletreatment discontinuationadherencecomplianceADHD medicationrelapseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1061-1083 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	treatment discontinuation adherence compliance ADHD medication relapse Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	treatment discontinuation adherence compliance ADHD medication relapse Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Treuer T Méndez L Montgomery W Wu S Factors affecting treatment adherence to atomoxetine in ADHD: a systematic review
description	Tamás Treuer,1 Luis Méndez,2 William Montgomery,3 Shenghu Wu4 1Neuroscience Research, Eli Lilly and Company, Budapest, Hungary; 2Eli Lilly de Mexico, Mexico City, Mexico; 3Global Patient Outcomes and Real World Evidence, Eli Lilly Australia Pty Ltd, West Ryde, NSW, Australia; 4Neuroscience Research, Eli Lilly Asia, Inc, Shanghai, People’s Republic of China Abstract: The purpose of this paper was to systematically review the literature related to research about the factors affecting treatment adherence and discontinuation of atomoxetine in pediatric, adolescent, and adult patients with attention-deficit/hyperactivity disorder (ADHD). Medline was systematically searched using the following prespecified terms: “ADHD”, “Adherence”, “Compliance”, “Discontinuation”, and “Atomoxetine”. We identified 31 articles that met all inclusion and exclusion criteria. The findings from this review indicate that persistence and adherence to atomoxetine treatment were generally high. Factors found to influence adherence and nonadherence to atomoxetine treatment in ADHD in this review include age, sex, the definition of response used, length of treatment, initial dose of treatment, comorbid conditions, and reimbursement. Tolerability was cited as an important reason for treatment discontinuation. More research is needed to understand those factors that can help to identify patients at risk for poor adherence and interventions that could improve treatment adherence early in the stage of this illness to secure a better long-term prognosis. Keywords: atomoxetine, treatment discontinuation, adherence, compliance, ADHD medication, relapse
format	article
author	Treuer T Méndez L Montgomery W Wu S
author_facet	Treuer T Méndez L Montgomery W Wu S
author_sort	Treuer T
title	Factors affecting treatment adherence to atomoxetine in ADHD: a systematic review
title_short	Factors affecting treatment adherence to atomoxetine in ADHD: a systematic review
title_full	Factors affecting treatment adherence to atomoxetine in ADHD: a systematic review
title_fullStr	Factors affecting treatment adherence to atomoxetine in ADHD: a systematic review
title_full_unstemmed	Factors affecting treatment adherence to atomoxetine in ADHD: a systematic review
title_sort	factors affecting treatment adherence to atomoxetine in adhd: a systematic review
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/0c83fb1ec3ff4d678fd633e08091cc78
work_keys_str_mv	AT treuert factorsaffectingtreatmentadherencetoatomoxetineinadhdasystematicreview AT mendezl factorsaffectingtreatmentadherencetoatomoxetineinadhdasystematicreview AT montgomeryw factorsaffectingtreatmentadherencetoatomoxetineinadhdasystematicreview AT wus factorsaffectingtreatmentadherencetoatomoxetineinadhdasystematicreview
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Factors affecting treatment adherence to atomoxetine in ADHD: a systematic review

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