Effect of upper respiratory infection on anaesthesia induced atelectasis in paediatric patients

Abstract Upper respiratory tract infection (URI) symptoms are known to increase perioperative respiratory adverse events (PRAEs) in children undergoing general anaesthesia. General anaesthesia per se also induces atelectasis, which may worsen with URIs and yield detrimental outcomes. However, the in...

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Autores principales:	Hye-Mi Lee, Hyo-Jin Byon, Namo Kim, Stephen J. Gleich, Randall P. Flick, Jeong-Rim Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0c84f6d31f7a46db8db9c5c3904e4ec4
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spelling	oai:doaj.org-article:0c84f6d31f7a46db8db9c5c3904e4ec42021-12-02T11:39:20ZEffect of upper respiratory infection on anaesthesia induced atelectasis in paediatric patients10.1038/s41598-021-85378-02045-2322https://doaj.org/article/0c84f6d31f7a46db8db9c5c3904e4ec42021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85378-0https://doaj.org/toc/2045-2322Abstract Upper respiratory tract infection (URI) symptoms are known to increase perioperative respiratory adverse events (PRAEs) in children undergoing general anaesthesia. General anaesthesia per se also induces atelectasis, which may worsen with URIs and yield detrimental outcomes. However, the influence of URI symptoms on anaesthesia-induced atelectasis in children has not been investigated. This study aimed to demonstrate whether current URI symptoms induce aggravation of perioperative atelectasis in children. Overall, 270 children aged 6 months to 6 years undergoing surgery were prospectively recruited. URI severity was scored using a questionnaire and the degree of atelectasis was defined by sonographic findings showing juxtapleural consolidation and B-lines. The correlation between severity of URI and degree of atelectasis was analysed by multiple linear regression. Overall, 256 children were finally analysed. Most children had only one or two mild symptoms of URI, which were not associated with the atelectasis score across the entire cohort. However, PRAE occurrences showed significant correspondence with the URI severity (odds ratio 1.36, 95% confidence interval 1.10–1.67, p = 0.004). In conclusion, mild URI symptoms did not exacerbate anaesthesia-induced atelectasis, though the presence and severity of URI were correlated with PRAEs in children. Trial registration: Clinicaltrials.gov (NCT03355547).Hye-Mi LeeHyo-Jin ByonNamo KimStephen J. GleichRandall P. FlickJeong-Rim LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hye-Mi Lee Hyo-Jin Byon Namo Kim Stephen J. Gleich Randall P. Flick Jeong-Rim Lee Effect of upper respiratory infection on anaesthesia induced atelectasis in paediatric patients
description	Abstract Upper respiratory tract infection (URI) symptoms are known to increase perioperative respiratory adverse events (PRAEs) in children undergoing general anaesthesia. General anaesthesia per se also induces atelectasis, which may worsen with URIs and yield detrimental outcomes. However, the influence of URI symptoms on anaesthesia-induced atelectasis in children has not been investigated. This study aimed to demonstrate whether current URI symptoms induce aggravation of perioperative atelectasis in children. Overall, 270 children aged 6 months to 6 years undergoing surgery were prospectively recruited. URI severity was scored using a questionnaire and the degree of atelectasis was defined by sonographic findings showing juxtapleural consolidation and B-lines. The correlation between severity of URI and degree of atelectasis was analysed by multiple linear regression. Overall, 256 children were finally analysed. Most children had only one or two mild symptoms of URI, which were not associated with the atelectasis score across the entire cohort. However, PRAE occurrences showed significant correspondence with the URI severity (odds ratio 1.36, 95% confidence interval 1.10–1.67, p = 0.004). In conclusion, mild URI symptoms did not exacerbate anaesthesia-induced atelectasis, though the presence and severity of URI were correlated with PRAEs in children. Trial registration: Clinicaltrials.gov (NCT03355547).
format	article
author	Hye-Mi Lee Hyo-Jin Byon Namo Kim Stephen J. Gleich Randall P. Flick Jeong-Rim Lee
author_facet	Hye-Mi Lee Hyo-Jin Byon Namo Kim Stephen J. Gleich Randall P. Flick Jeong-Rim Lee
author_sort	Hye-Mi Lee
title	Effect of upper respiratory infection on anaesthesia induced atelectasis in paediatric patients
title_short	Effect of upper respiratory infection on anaesthesia induced atelectasis in paediatric patients
title_full	Effect of upper respiratory infection on anaesthesia induced atelectasis in paediatric patients
title_fullStr	Effect of upper respiratory infection on anaesthesia induced atelectasis in paediatric patients
title_full_unstemmed	Effect of upper respiratory infection on anaesthesia induced atelectasis in paediatric patients
title_sort	effect of upper respiratory infection on anaesthesia induced atelectasis in paediatric patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0c84f6d31f7a46db8db9c5c3904e4ec4
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Effect of upper respiratory infection on anaesthesia induced atelectasis in paediatric patients

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